Education

B.S. Huazhong Agricultural University, Biological Sciences, 2018;

Ph.D. Peking University, Biochemistry and Molecular Biology, 2023;

Professional Experience

Postdoctoral Fellow, Peking University, Biochemistry and Molecular Biology, 2026;

Professor, School of Life Sciences, Xiamen University, 2026

Research Area

RNA chemical modifications function as“molecular switches”in essential life processes such as the regulation of gene expression and cell fate determination, not only expanding the boundaries of RNA biology but also revealing entirely new regulatory mechanisms and research directions. Across diverse physiological and pathological contexts, RNA modifications exert critical regulatory functions, making their associated pathways and factors important diagnostic and therapeutic targets and providing new strategies for disease intervention. Although the field of RNA modification research is developing rapidly, many underlying mechanisms remain insufficiently understood, highlighting an urgent need for continued breakthroughs in new technologies, functions, and mechanisms. To this end, our research group will focus on the following directions: 1. Develop spatial single-cell multi-omics technologies to delineate the spatiotemporal heterogeneity and context-specific distribution patterns of RNA modifications within tissue microenvironments. 2. Promote multidisciplinary, integrative research to construct and elucidate dynamic regulatory networks and functional maps of nucleic acid modifications in key physiological and pathological processes. 3. Focus on cell-surface RNA modifications to systematically dissect their mechanisms of occurrence, establish detection methods, clarify their biological functions, and explore strategies for controllable manipulation and applications.

Selected Publications (*Corresponding author, #co-first author)

1. Sun H.#, Lu B.#, Zhang Z.#, Xiao Y., Zhou Z., Xi L., Li Z., Jiang Z., Zhang J., Wang M., Liu C., Ma Y., Peng J., Wang X.-J.* & Yi C.* Mild and ultrafast GLORI enables absolute quantification of m6A methylome from low-input samples. Nature Methods, 22, 1226-1236 (2025)
2. Sun H.#, Teng Q.#, Liu W.#, Guo R.#, Li M.#, Xiong W., Huang Q., Yu Q., Luo N., Li Y., Song J., Gong S., Shi X.*, Yi C.* & Liu K.* CRISPR-free RNA Base Editing Mediated PTC-readthrough Restores Hearing in Mice with Otof Nonsense Mutation. Nature Communications, 17, 413 (2026)
3. Shen W.#, Sun H.#, Liu C.#, Yi Y., Hou Y., Xiao Y., Hu Y., Lu B., Peng J., Wang J.* & Yi C.*. GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution. Nature Protocols 19, 1252-1287 (2024).
4. Sun H.#, Li K.#, Liu C.# & Yi C.* Regulation and functions of non-m6A mRNA modifications. Nature Reviews Molecular Cell Biology, 24, 714-731 (2023).
5. Liu C.#, Sun H.#, Yi Y.#, Shen W.#, Li K.#, Xiao Y., Li F., Li Y., Hou Y., Lu B., Liu W., Meng H., Peng J., Yi C.* & Wang J.* Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI. Nature Biotechnology, 41, 355–366 (2023).
6. Song J.#, Dong L.#, Sun H.#, Luo N.#, Huang Q.#, Li K., Shen X., Jiang Z., Lv Z., Peng L., Zhang M., Wang K., Liu K., Hong J. & Yi C.* CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons. Molecular Cell 83, 139–155 (2023).
7. Sun H.#, Li K.#, Zhang X., Liu J., Zhang M., Meng H. & Yi, C.* m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome. Nature Communications, 12, 4778 (2021).
8. Sun H.#, Zhang M.#, Li K., Bai D. & Yi C.* Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase. Cell Research, 29, 80–82 (2019).