Education

B.S. Biology, Xiamen University, 1997
M.S. Biology, Xiamen University, 2000
Ph.D. Pathology, Yeshiva University, 2006

Professional Experience

2007-2012,Postdoctoral Fellow, Harvard Medical School
2012-2013,Associate Professor, School of Life Sciences, Xiamen University
2011-Now,Professor, School of Life Sciences, Xiamen University

Research Area

The Hippo kinase Mst1, a homolog of the Drosphila tumor suppressor hippo, is a key determinant of peripheral T cell activation, proliferation and maturation. The combined deletion of Mst1 and Mst2 from the hematopoietic compartment results in the absence of all peripheral lymphocytes and a profound immunodeficiency syndrome. Our research group proposes to characterize the regulation and physiologic functions of the Hippo pathway in the immune system.

Selected Publications (*Corresponding author, #co-first author)

1.Jinjia Zhang ^#; Junhong Li^#; Yongqiang Hou ^#;Yao Lin ^#; Hao Zhao^#; Yiran Shi ^#; Kaiyun Chen; Cheng Nian; Jiayu Tang; Lei Pan; Yunzhi Xing; Huan Gao; Bingying Yang; Zengfang Song; Yao Cheng; Yue Liu; Min Sun; Yueyue Linghu; Jiaxin Li; Haitao Huang; Zhangjian Lai; Zhien Zhou; Zifeng Li; Xiufeng Sun; Qinghua Chen; Dongxue Su; Wengang Li; Zhihai Peng; Pingguo Liu; Wei Chen; Hongling Huang; Yixin Chen; Bailong Xiao; Lilin Ye^*; Lanfen Chen^*; Dawang Zhou^*. Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor. Cell. 2024 May 9:S0092-8674(24)00448-3.
2.Dongxue Su^#; Yuxi Li^#; Weiji Zhang^#; Huan Gao^#; Yao Cheng^#; Yongqiang Hou; Junhong Li;  Yi Ye; Zhangjian Lai; Zhe Li; Haitao Huang; Jiaxin Li; Jinhuan Li; Mengyu Cheng; Cheng Nian; Na Wu; Zhien Zhou; Yunzhi Xing; He Liu; Jiayu Tang; Yu Zhao; Qinghua Chen; Lixin Hong; Wengang Li; Zhihai Peng; Bin Zhao; Randy L. Johnson; Pingguo Liu; Wanjin Hong; Lanfen Chen^*; Dawang Zhou^*. SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling. J Clin Invest. 2023 Oct 16;133(20):e168888.
3.Qingxu Liu^#; Jiaxin Li^#; Weiji Zhang^#; Chen Xiao^#; Shihao Zhang^#; Cheng Nian; Junhong Li; Dongxue Su; Lihong Chen; Qian Zhao; Hui Shao; Hao Zhao; Qinghua Chen; Yuxi Li; Jing Geng; Lixin Hong; Shuhai Lin; Qiao Wu; Xianming Deng; Rongqin Ke; Jin Ding; Randy L. Johnson; Xiaolong Liu; Lanfen Chen^*; Dawang Zhou^*. Glycogen accumulation and phase separation drives liver tumor initiation. Cell. 2021 Oct 28; 184(22):5559-5576.e19.
4.Jing Geng^#; Yiran Shi^#; Jinjia Zhang^#; Bingying Yang; Ping Wang; Weihong Yuan; Hao Zhao; Junhong Li; Funiu Qin; Lixin Hong; Changchuan Xie; Xianming Deng; Yujie Sun; Congying Wu; Lanfen Chen^*; Dawang Zhou^*. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection. Nature Communications. 2021 Jun 10, 12(1):3519.
5.Ping Wang^#; Jing Geng^#; Jiahui Gao; Hao Zhao; Junhong Li; Yiran Shi; Bingying Yang; Chen Xiao; Yueyue Linghu; Xiufeng Sun; Xin Chen; Lixin Hong; Funiu Qin; Xun Li; Jau-Song Yu; Han You; Zengqiang Yuan; Dawang Zhou; Randy L. Johnson；Lanfen Chen^*. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nature Communications. 2019 Feb 14; 10(1):755.
6.Shihao Zhang^#; Qinghua Chen^#; Qingxu Liu^#；Yuxi Li; Xiufeng Sun; Lixin Hong; Suyuan Ji; Chenyan Liu; Jing Geng; Weiji Zhang; Zhonglei Lu; Zhen-Yu Yin; Yuanyuan Zeng; Kwang-Huei Lin; Qiao Wu; Qiyuan Li; Keiko Nakayama; Keiich I Nakayama; Xianming Deng; Randy L Johnson; Liang Zhu; Daming Gao; Lanfen Chen^*; Dawang Zhou^*. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell. 2017 May 8; 31(5):669-684.e7.
7.Jing Geng^#; Shujuan Yu^#; Hao Zhao^#; Xiufeng Sun^#; Xun Li; Ping Wang; Xiaolin Xiong; Lixin Hong; Changchuan Xie; Jiahui Gao; Yiran Shi; Jiaqi Peng; Randy L Johnson; Nengming Xiao; Linrong Lu; Jiahuai Han; Dawang Zhou^*; Lanfen Chen^*. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nature Immunology. 2017 Jul; 18(7):800-812.
8.Jing Geng^#; Xiufeng Sun^#; Ping Wang; Shihao Zhang; Xiaozhen Wang;Hongtan Wu; Lixin Hong; Changchuan Xie;Xun Li; Hao Zhao; Qingxu Liu; Mingting Jiang; Qinghua Chen; Jinjia Zhang;, Yang Li; Siyang Song; Hong-Rui Wang; Rongbin Zhou; Randy L Johnson; Kun-Yi Chien; Sheng-Cai Lin; Jiahuai Han; Joseph Avruch; Lanfen Chen^*; Dawang Zhou^*. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature Immunology. 2015 Nov; 16(11):1142-52.
9.Hongtan Wu^#; Luyao Wei^#; Fuqin Fan^#; Suyuan Ji^#; Shihao Zhang; Jing Geng; Lixin Hong; Xin Fan; Qinghua Chen; Jing Tian; Mingting Jiang; Xiufeng Sun; Changnan Jin; Zhen-Yu Yin; Qingxu Liu; Jinjia Zhang; Funiu Qin; Kwang-Huei Lin; Jau-Song Yu; Xianming Deng; Hong-Rui Wang; Bin Zhao; Randy L Johnson; Lanfen Chen^*; Dawang Zhou^*. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nature Communications. 2015 Feb 19; 6:6239.
10.Hongtan Wu^#; Yubo Xiao^#; Shihao Zhang^#; Suyuan Ji; Luyao Wei; Fuqin Fan; Jing Geng; Jing Tian; Xiufeng Sun; Funiu Qin; Changnan Jin; Jianjun Lin; Zhen-Yu Yin;  Ting Zhang; Lianzhong Luo; Yang Li; Siyang Song; Sheng-Cai Lin,; Xianming Deng; Fernando Camargo; Joseph Avruch; Lanfen Chen^* and Dawang Zhou^*. The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense. Cell Reports. 2013 May 30; 3:1663-1677.