Education

B.S. 2014, Xiamen University, Biotechnology;
Ph.D. 2019, Xiamen University, Cell Biology;

Professional Experience

Joint training Ph.D. University of California, Berkeley, 2017-2019;
Postdoctoral Fellow, University of California, Berkeley, 2019-2020;
Assistant Professor, School of Life Sciences, Xiamen University, 2021 to Present.

Research Area

We mainly engaged in the functional research of matricellular proteins in tissue microenvironment remodeling, tumor metastasis and cardiovascular diseases. The main research direction is the mutual regulation between different cells in the tissue microenvironment through matricellular proteins and cytokines. Further explore the important functions and mechanisms of matricellular proteins and their inhibitors in the regulation of tissue microenvironment homeostasis and tumor microenvironment, which provides theoretical basis and potential targets for the treatment of major diseases such as tissue fibrosis, malignant tumors, and cardiovascular diseases.

Selected Publications

1.Lu Y^#, Wu T^#, Gutman O, Lu H, Zhou Q, Henis YI, Luo K^*. Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression. Nature Cell Biology, 2020; 22:453-464. (Highlighted in News & Views by Nature Cell Biology; Recommended by F1000)
2.Wu T^#, Huang J^#, Wu S^#, Huang Z^#, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F^*, Ouyang G^*. Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biology, 2018; 66:81-92.
3.Ma H, Wang J, Zhao X, Wu T, Huang Z, Chen D, Liu Y^*, Ouyang G^*. Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation. Cell Reports, 2020; 30(3):793-806.
4.Huang Y^#, Liu W^#, Xiao H^#, Maitikabili A, Lin Q, Wu T, Huang Z, Liu F, Luo Q, Ouyang G^*. Matricellular protein periostin contributes to hepatic inflammation and fibrosis. The American Journal of Pathology, 2014; 185(3):786-97.
5.Liu AY^#, Cai Y^#, Mao Y^#, Lin Y, Zheng H, Wu T, Huang Y, Fang X, Lin S, Feng Q, Huang Z, Yang T, Luo Q^*, Ouyang G^*. Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. Carcinogenesis, 2014; 35(3):537-45.
6.Wu T, Wu S, Ouyang G^*. Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metabolism, 2014; 20(4):562-4. (Previews)
7.Wu T, Luo Q^*, Ouyang G^*. Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage. Protein & Cell, 2015; 6(4):235-7. (News and views)
8.Wu T, Ouyang G^*. Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein & Cell, 2014; 5(4):249-52c. (Perspective)