 | Tao-ling Zeng, Ph.D. Associate Professor. E-mail: zengtaoling@xmu.edu.cn |
Education
B.S., Southwest University, 2009
Ph.D., Xiamen University, 2014
Professional Experience
Engineer, School of Life Sciences, Xiamen University, 2015-2019;
Assistant Professor, School of Life Sciences, Xiamen University, 2019-2024；
Associate Professor, School of Life Sciences, Xiamen University, 2025 to Present.
Research Area
Protein post-translational modifications such as ubiquitination and ubiquitin-like modification are key regulatory mechanisms that control various biological processes. Dysregulation of protein modification results in development of many human diseases like neurodegenerative disease and cancer. Our research interest has been focused on mechanism studies of ubiquitination and ubiquitin-like modification in regulation of cell proliferation, cell death, autophagy, and tumorigenesis. We are also working on identifying small-molecule modulators of E3 ubiquitin ligases that are critical for cancer development, which is emerging as a promising drug discovery strategy.
Selected Publications (*Corresponding author, #co-first author)
1. Taoling Zeng#; Tingting Jiang#; Baoding Zhang#; Ting Zhang#; Wanjun Dai; Xun Yin; Yunzhan Li; Zhuoran Yu; Caiming Wu; Yaying Wu; Ximin Chi; Xianming Deng*; Hong-Rui Wang*; Targeting oncogenic K-RAS mutants with small-molecule degrader XMU-MP-9 through NEDD4-1, Acta Pharmaceutica Sinica B, 2026, 16(2): 979-993.
2. Jing Bi#; Zhihui Wu#; Xin Zhang#; Taoling Zeng#; Wanjun Dai; Ningyuan Qiu; Mingfeng Xu; Yikai Qiao; Lang Ke; Jiayi Zhao; Xinyu Cao; Qi Lin; Xiao Lei Chen; Liping Xie; Zhong Ouyang; Jujiang Guo; Liangkai Zheng; Chao Ma; Shiying Guo; Kangmei Chen; Wei Mo; Guo Fu*; Tong-Jin Zhao*; Hong-Rui Wang*; TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triplenegative breast cancer progression, Nature Communications, 2023, 14(1).
3. Maoyuan Tian#, Taoling Zeng#, Mingdong Liu, Shang Han, Huayue Lin, Qi Lin, Li Li, Tingting Jiang, Gao Li, Hong Lin, Ting Zhang, Qiaofeng Kang, Xianming Deng*, Hong-Rui Wang*. A cell-based high-throughput screening method for modulators of E3 ligases using ubiquitin-reference-technique (URT) technique. J Biol Chem, 2019, 294(8): 2880-2891.
4. Mingdong Liu#, Taoling Zeng#, Xin Zhang#, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao*, Hong-Rui Wang*. ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nature Communications, 2018, 9:4139.
5. Zeng T#, Wang Q#, Fu J#, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H,Wang M, Lu B, Deng X, Zhou D, Yin Z*, Wang HR*. Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis. Cell Reports, 2014,7(3):871-82.
6. Wang M#, Guo L#, Wu Q#, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, RenL, Zhang S, Pei Y, Yin Z, Ding F, Wang HR*.ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance. Nature Communications, 2014, 5:4901
