Education

2006, B.S., Northeast Normal University

2012, Ph.D., Xiamen University

Research Area

Postdoctoral Fellow, Zhongshan Hospital, Xiamen University, 2012-2015
Assistant Professor, School of Life Sciences, Xiamen University, 2015-2023

Associate professor, School of Life Sciences, Xiamen University, 2023 to Present.

Research Area

Cell metabolism and signal regulation

Selected Publications

1. Wang J^#, Guo H^#, Zheng LF^#, Li P^*, Zhao TJ^*. Context-specific fatty acid uptake is a finely-tuned multi-level effort. Trends in Endocrinology and Metabolism. 2024 Oct 25. doi: 10.1016/j.tem.2024.10.001.Online ahead of print.
2.Wang S, He T, Luo Y, Ren K, Shen H, Hou L, Wei Y, Fu T, Xie W, Wang P, Hu J, Zhu Y, Huang Z, Li Q, Li W, Guo H^*, Li B^*. SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice. Cell Death Differ. 2024 Oct 15. doi: 10.1038/s41418-024-01397-0. Online ahead of print.
3.Lu R, Hong J, Fu T, Zhu Y, Tong R, Ai D, Wang S, Huang Q, Chen C, Zhang Z, Zhang R^*, Guo H^*, Li B^*. Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics. Advanced Science (Weinh). 11(24):e2308945, 2024.
4. Wang J, Zheng LF, Ren S, Li DL, Chen C, Sun HH, Liu LY, Guo H^*, Zhao TJ^*. ARF6 plays a general role in targeting palmitoylated proteins from golgi to the plasma membrane. J Cell Sci. 136(15):jcs261319, 2023.
5. Liu Y^#, He T^#, Li Z, Sun Z, Wang S, Shen H, Hou L, Li S, Wei Y, Zhuo B, Li S, Zhou C, Guo H^*, Zhang R^*, Li B^*. TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation. iScience. 26(11):108312, 2023.
6. Guo H^#, Wang J^#, Ren S^#, Zheng LF^#, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ^*. Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Nat Commun. 13(1):6004, 2022.
7. Shen H^#, He T^#, Wang S^#, Hou LF^#, Wei YX, Liu YJ, Mo CL, Zhao ZH, You WX, Guo HL^*, Li BA^*. SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex. Theranostics, 12(18): 7699-7716, 2022.
8. Hao JW^#, Wang J^#, Guo H^#, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie C, Hong L, Huang X, Wang HR, Li CB, Liang B, Chen S, Zhao TJ^*. Nat Commun. 11(1):4765, 2020.
9. Wang J^#, Hao JW^#, Wang X^#, Guo H^#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ^*. DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep. 26(1):209-221, 2019.
10. Zhang YL^#, Guo HL^#, Zhang CS^#, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC^*. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab.18(4):546-555, 2013.
11. Guo HL^#, Zhang C^#, Liu Q^#, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z, Lin SY, Lin SC. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Res. 22: 1246-1257,2012.