Education

1999-2003, B.Sc., School of Life Science, Northwest University (Xi'an);

2003-2009, Ph.D., School of Life Sciences, Xiamen University;

2006-2007, Utah State University，exchange scholar.

Professional Experience

2020 to Present,Associate Professor, School of Life Sciences, Xiamen University

Research Area

We utilize E. multilocularis, one of the most important human helminthic pathogens, as the experimental model to investigate the roles of host factor-mediated signaling pathways in parasite’s growth and development. We are particularly interested in the contributions of host factors to the self-renewal, pluripotency maintenance and cell specification of E. multilocularis somatic stem cells.

Selected Publications (*Corresponding author, #co-first author)

1.Cheng Z, Xu Z, Tian H, Liu F, Li X, Luo D, Wang Y. In vitro and in vivo efficacies of the EGFR/MEK/ERK signaling inhibitors in the treatment of alveolar echinococcosis. Antimicrob Agents Chemother. 2020, 64(8): e00341-20.
2.Cheng Z, Liu F, Tian H, Xu Z, Chai X, Luo D, Wang Y. Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase. PLoS Negl Trop Dis. 2019, 13(5): e0007425.
3.Cheng Z, Liu F, Dai M, Wu J, Li X, Guo X, Tian H, Heng Z, Lu Y, Chai X, Wang Y, Identification of EmSOX2, a member of the Sox family of transcription factors, as a potential regulator of Echinococcus multilocularis germinative cells. Int J Parasitol. , 2017, 47(10-11): 625-632.
4.Cheng Z, Liu F, Li X, Dai M, Wu J, Guo X, Tian H, Heng Z, Lu Y, Chai X, Wang Y, EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. PLoS Negl Trop Dis. , 2017, 11(2): e0005418.
5.Cheng Z, Zhu S, Wang L, Liu F, Tian H, Pengsakul T, Wang Y, Identification and characterisation of Emp53, the homologue of human tumor suppressor p53, from Echinococcus multilocularis: its role in apoptosis and the oxidative stress response. Int J Parasitol. , 2015, 45(8): 517-526.
6.Cheng Z, Liu F, Zhu S, Wang L, Wang Y, A rapid and convenient method for fluorescence analysis of in vitro cultivated metacestode vesicles from Echinococcus multilocularis. PLoS One, 2015, 10(2): e0118215.
7.Cheng Z, Tian H, Chu H, Wu J, Li Y, Wang Y, The effect of  tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway. Toxicol Lett. , 2014, 225(3): 413-421.
8.Wang Y^#, Cheng Z^#, Lu X, Tang C, Echinococcus multilocularis: Proteomic analysis of the protoscoleces by two-dimensional electrophoresis and mass spectrometry. Exp Parasitol. , 2009, 123(2): 162-167.