 | Ying Gu, Ph.D. Professor. Tel: +86-592-2187880 Fax: +86-592-2181258 E-mail: guying@xmu.edu.cn |
Education
B.S. 2000, Xiamen University, Biochemistry;
Ph.D. 2006, Xiamen University, Cell Biology;
Professional Experience
Visiting Scholar, Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), National Health Institute (NIH), 2018-2019;
Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University, 2006 to Present.
Research Area
Screening of antiviral monoclonal antibodies, in particular, for HIV neutralizing antibodies Structural and functional demonstration of critical antiviral immune epitopes Virus antigen investigation based on the structural information of immune epitopes.
Selected Publications
1. Li T#*, Xue W#, Zhang S#, Wang H#, Lan M#, Zhang L#, Lin M#, Zhou M#, Ying D#, Zeng Y, Cui L, Yin Y, Chen H, Ma J, Liu C, Chen J, Wang C, Yu Z, Chen Y, Wu Y, Liu H, Li H, Zhang Y, Li J, Lu Z, Chen Z, Zhang Y, Yuan L, Zhou L, Zheng Q, Yu H, Zhang J, Cheng T, Chen J*, Chen Y, Guan Y, Zheng Z*, Gu Y*, Xia N*, Li S*. Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections. Nat Biomed Eng. 2026 Jul;10(7):1373-1391. doi: 10.1038/s41551-025-01529-y. (News & views: Kealy LC, Good-Jacobson KL. Non-covalent assembly of multiple epitopes onto a single nanoparticle. Nat Biomed Eng. 2026 Jul;10(7):1275-1276. doi: 10.1038/s41551-025-01530-5.)
2. Wang Z#, Wang D#, Chen J#, Gao F, Jiang Y, Yang C, Qian C, Chi X, Zhang S, Xu Y, Lu Y, Shen J, Zhang C, Li J, Zhou L, Li T, Zheng Q, Yu H, Li S*, Xia N*, Gu Y*. Rational design of a cross-type HPV vaccine through immunodominance shift guided by a cross-neutralizing antibody. Sci Bull (Beijing). 2024 Feb 26;69(4):512-525.
3. Zheng M#, Zhou L#, Huang Y#, Zhang X, Yu Z, Yang C, Chen Y, Ying D, Wang H, Chen Z, Liu C, Tang Z, Wang S, Wang K, Yang K, Lin Y, Li T, Zheng Q, Zheng Z, Zhang J, Yu H*, Li S*, Gu Y*, Xia N*. Structural basis for the synergetic neutralization of hepatitis E virus by antibody-antibody interaction. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2408585121.
4. Chen J#, Wang D#, Wang Z#, Wu K, Wei S, Chi X, Qian C, Xu Y, Zhou L, Li Y, Zhang S, Li T, Kong Z, Wang Y, Zheng Q, Yu H, Zhao Q, Zhang J, Xia N, Li S, Gu Y*. Critical Residues Involved in the Coassembly of L1 and L2 Capsid Proteins of Human Papillomavirus 16. J Virol. 2023 Mar 30;97(3):e0181922. doi: 10.1128/jvi.01819-22.
5. Zheng Q#, Zhu R#, Yin Z#, Xu L#, Sun H#, Yu H#, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y*, Cheng T*, Li S*, Xia N*. Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe. 2022 Sep 14;30(9):1279-1294.e6.
6. Li T#, Chen J#, Zheng Q#, Xue W#, Zhang L#, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y*, Chen Y*, Li S*, Xia N*. Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun. 2022 Sep 2;13(1):5182.
7. T Li#, W Xue#, Q Zheng#, S Song#, C Yang#, H Xiong#, S Zhang, M Hong, Y Zhang, H Yu, Y Zhang, H Sun, Y Huang, T Deng, X Chi, J Li, S Wang, L Zhou, T Chen, Y Wang, T Cheng, T Zhang, Q Yuan, Q Zhao, J Zhang, J. S. McLellan, Z Zhou*, Z Zhang*, S Li*, Y Gu*, N Xia*. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun, 2021, 12(1): 5652-5664.
8. D Wang#, X Liu#, M Wei#, C Qian, S Song, J Chen, Z Wang, Q Xu, Y Yang, M He, X Chi, S Huang, T Li, Z Kong, Q Zheng, H Yu, Y Wang, Q Zhao, J Zhang, N Xia*, Y Gu*, S Li*. Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. Nat Commun, 2020, 11(1):2841.
9. Zheng Q#, Jiang J#, He M#, Zheng Z#, Yu H, Li T, Xue W, Tang Z, Ying D, Li Z, Song S, Liu X, Wang K, Zhang Z, Wang D, Wang Y, Yan X, Zhao Q, Zhang J, Gu Y*, Li S*, Xia N*. Viral neutralization by antibody-imposed physical disruption. Proc Natl Acad Sci U S A. 2019 Dec 9.
10. Li Z#, Song S#, He M#, Wang D, Shi J, Liu X, Li Y, Chi X, Wei S, Yang Y, Wang Z, Li J, Qian H, Yu H, Zheng Q, Yan X, Zhao Q, Zhang J, Gu Y*, Li S*, Xia N*. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun. 2018 Dec 18;9(1):5360.
