Education

B.S. Shandong University, Biotechnology, 2011;
Ph.D. Institute of Biophysics, Chinese Academy of Science, Cell Biology, 2016;

Professional Experience

Assistant Research Scientist, Institute of Biophysics, Chinese Academy of Science, 2016-2018;
Postdoctoral Fellow, Department of Immunobiology, Yale University, 2018-2023;
Associate Research Scientist, Department of Immunobiology, Yale University, 2023-2024;
Professor, School of Life Sciences, Xiamen University, 2025

Research Area

The central nervous system has specific anatomical structure, tissue microenvironment, and unique immune surveillance mechanism and is considered a relatively immune-privileged organ However, it is now established that the nervous system and the immune system possess a bidirectional and complex interaction, which plays a pivotal role in the perception of internal and external environmental stimuli and the maintenance of physiological homeostasis. The immune system participates in the development of the central nervous system and regulate the central nervous system function in both physiological and pathophysiological condition. Our research team is dedicated to unraveling the unique mechanisms underlying the interaction and regulation between the nervous system and the immune system, elucidating the roles of specific microenvironments, immune cell populations, immune organs, and lymphatic vessels in modulating the functions of the nervous system. Our research not only uncovers the cutting-edge scientific issue of the unique immune mechanisms of the central nervous system but also have direct potential for being implemented in the treatment of central nervous system infections, tumors, neurodegenerative diseases, and other related conditions.

Selected Publications

1)Xiangyun Yin^#; Sophia Zhang^#; Ju Hyun Leev; Huiping Dong; George Mourgkos; Gordon Terwilliger; Aurora Kraus; Luiz Henrique Geraldo; Mathilde Poulet; Suzanne Fischer; Ting Zhou; Farrah Shalima Mohammed; Jiangbing Zhou; Yongfu Wang; Seth Malloy; Nicolas Rohner; Lokesh Sharma; Irene Salinas; Anne Eichmann; Jean-Leon Thomas; W. Mark Saltzman; Anita Huttner; Caroline Zeiss; Aaron Ring; Akiko Iwasaki; Eric Song ; Compartmentalized ocular lymphatic system mediates eye–brain immunity, Nature, 2024, 628(8006): 204-211. (^# equal contribution).
2)Dong Liu^#, Xiangyun Yin^#, Sam J. Olyha, Manuela Sales L. Nascimento, Pei Chen, Theresa White, Uthaman Gowthaman, Jake A. Gertie, Biyan Zhang, Lan Xu, Marina Yurieva, Lesley Devine, Adam Williams,^* Stephanie C. Eisenbarth,^* IL-10-dependent crosstalk between murine marginal zone B cells, macrophages and CD8α+ dendritic cells promotes Listeria monocytogenes infection.  Immunity, 2019 Jul 16;51(1):64-76.e7. (^# equal contribution).
3)Xiangyun Yin, Shuting Chen, and Stephanie C. Eisenbarth. Dendritic Cell Regulation of T Helper Cells.  Annual Review of Immunolog, 2021,39: 759-90.
4)Elise G Liu ^#, Xiangyun Yin ^#, Emily R Siniscalco, Stephanie C Eisenbarth.  Dendritic cells in food allergy, treatment, and tolerance. Journal of Allergy and Clinical Immunology. 2024 Sep;154(3):511-522. (^# equal contribution).
5)Elise G. Liu^#, Xiangyun Yin^# , Anush Swaminathan and Stephanie C. Eisenbarth. Antigen-Presenting Cells in Food Tolerance and Allergy. Frontiers in Immunology, 2020, 11: 616020. (^# equal contribution).
6)Xiangyun Yin, Stephanie C Eisenbarth. Torn between type 1 and type 2 immunity. Science Immunology. 2020 Nov 6;5(53):eabf4905.
7)Xiangyun Yin, Stephanie C Eisenbarth. Escape from the pore. Science Immunology. 2023 Aug 4;8(86):eadj9549.
8)Xiangyun Yin, Haisheng Yu, Jinxiao Yang, Jingyun Li, Hao Guo, Quanxing Shi, Zhao Yin, Xu Yong, Xuefei Wang, Rong Liu, Shouli Wang, Liguo Zhang. Human blood CD1c+ dendritic cells encompass two subsets that differ significantly in phenotype, gene expression and functions. Journal of Immunology, 2017, 198(4): 1553-64.
9)Biyan Zhang^#; Shuting Chen^#; Xiangyun Yin; Caleb D. McBride; Jake A. Gertie; Marina Yurieva; Agata A. Bielecka; Brian Hoffmann; Travis Hinson; Jessica Grassmann; Lan Xu; Emily R. Siniscalco; Arielle Soldatenko; Laura Hoyt; Julie Joseph; Elizabeth B. Norton; Gowthaman Uthaman; Noah W. Palm; Elise Liu; Stephanie C. Eisenbarth; Adam William. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8, Mucosal Immunology. 2024 Jun;17(3):431-449.
10)Ligia Simoes Braga Boisserand; Luiz Henrique Geraldo; Jean Bouchart; Marie-Renee El Kamouh; Seyoung Lee; Basavaraju G. Sanganahalli; Myriam Spajer; Shenqi Zhang; Sungwoon Lee; Maxime Parent; Yuechuan Xue; Mario Skarica; Xiangyun Yin; Justine Guegan; Kevin Boyé; Felipe Saceanu Leser; Laurent Jacob; Mathilde Poulet; Mingfeng Li; Xiodan Liu; Sofia E. Velazquez; Ruchith Singhabahu; Mark E. Robinson; Michael H. Askenase; Artem Osherov; Nenad Sestan; Jiangbing Zhou; Kari Alitalo; Eric Song; Anne Eichmann; Lauren H. Sansing; Helene Benveniste; Fahmeed Hyder; Jean-Leon Thomas. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model, Journal of Experimental Medicine. 2024 Apr 1;221(4):e20221983.
11)Jake A. Gertie, Biyan Zhang, Elise G. Liu, Laura R. Hoyt, Xiangyun Yin, Lan Xu, Lauren L. Long, Arielle Soldatenko, Uthaman Gowthaman, Adam Williams, and Stephanie C. Eisenbarth, 2021. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations.  Journal of Allergy and Clinical Immunology, 2021 May 27;S0091-6749(21)00820-4.
12)Haisheng Yu, Peng Zhang, Xiangyun Yin, Zhao Yin, Quanxing Shi, Ya Cui, Shouli Wang, Pier Paolo Piccaluga, Taijiao Jiang, Liguo Zhang. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. 2015, Protein & cell 6: 297-306.
13)Hao Guo, Jialong Zhang, Xuyuan Zhang, Yanbing Wang, Haisheng Yu, Xiangyun Yin, Jingyun Li, Peishuang Du, Joël Plumas, Laurence Chaperot, Jianzhu Chen, Lishan Su, Yong-jun Liu, Zhang Liguo^*, SCARB2/LIMP-2 regulates IFN production of plasmacytoid dendritic cells by mediating endosomal translocation of TLR9 and nuclear translocation of IRF7, Journal of Immunology, 2015, 194 (10): 4737-4749. (IF=5.4)