Education

2001, School of Life Sciences, Xiamen University, Bachelor

2011, School of Life Sciences,University of California,San Diego,Ph.D.

Professional Experience

2002-2005, Sanford-Burnham

2011-2013, University of California,San Diego

2013-present, School of Life Sciences, Xiamen University, Professor

Selected Publications (*Corresponding author, #co-first author)

1. Lin Xia*, Jun-yi Liu, Chao Yu, Hong-wei Lin, Ya-hong Hu, Guo-sheng Hu, Yao-hui He, Yun-yao Chen, Wen-xin Luo*, Ning-shao Xia*, Wen Liu*. PILRα on tumor cells interacts with the T cell surface protein CD99 to suppress antitumor immunity. Nature Cancer. 2025 May 1.doi: 10.1038/s43018-025-00958-7. (最后通讯作者)

2.Wen-juan Li, Yan-chao Chen, Yi-an Lin, Yi-qin Zou, Guo-sheng Hu, Jing-jing Yang, Xin-yu Nie, Mei-yan Li, Yi-ran Wang, Yao-hui, He, Yan Zhao, Yu-hua Tan, Xian-ming Deng, Wei-ling He, Yan Cheng*, Fang-meng Fu*, Wen Liu*. Hypoxia-inducedPRMT1 Methylates HIF2bto Promote Breast Tumorigenesis via Enhancing Glycolytic Gene Transcription. Cell Reports. 2025 Apr 1;44(4):115487. doi: 10.1016/j.celrep.2025.115487. (最后通讯作者)
3.Guo-sheng Hu, Zao-zao Zheng, Yao-hui He, Du-chuang Wang, Rui-chao Nie, Wen Liu*. Integrated Analysis of Proteome and Transcriptome Profiling Reveals Pan-Cancer-Associated Pathways and Molecular Biomarkers. Molecular & Cellular Proteomics. 2025 Mar;24(3):100919. doi: 10.1016/j.mcpro.2025.100919. (唯一通讯作者)
4.Jia Yi, Jiao Du, Xue Chen, Rui-chao Nie, Guo-sheng Hu, Lei Wang, Yue-ying Zhang, Shang Chen, Xiao-sha Wen, Di-xian Luo*, Hua He*, Wen Liu*. A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer. The Proceedings of the National Academy of Sciences. 2025 Feb;122 (8) e2420383122. doi:10.1073/pnas.2420383122.(最后通讯作者)
5.Jing-jing Yang, Wen-juan Li, Ze-peng Zhang, Xiao-hua Gong, Yan-chao Chen, Xiao-yu Peng, Guo-sheng Hu, Xiang-long Dai, Yao-hui He, Ying Huang, Shi-qiang Cao, Yang Yang*, Wen Liu*. Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication. The Proceedings of the National Academy of Sciences. 2024 Nov 19;121(47):e2408117121. doi: 10.1073/pnas.2408117121. (最后通讯作者)
6、Ziying Wang, Yaohui He, Yibo An, Guosheng Hu, Yubo Tan, Dazhuang Xu, Renyuan Liu, Lijuan Yang, Man Li, Yi Cheng, Liyan Zheng, Wen Liu*, Gang Liu*, Zhixiang Lu*. Mitochondrion-specifc organometallic sonosensitizer boost.
7、Bing-ling Peng, Ting Ran, Xue Chen, Jian-cheng Ding, Zi-rui Wang, Wen-juan Li, Wen Liu*. A CARM1 inhibitor potently suppresses breast cancer both in vitro and in vivo, J Med Chem. 2024 May 23;67(10):7921-7934. (*通讯作者)
8、Xue Chen, Ming-feng Huang, Da-meng Fan, Yao-hui He, Wen-juan Zhang, Jian-cheng Ding, Bing-ling Peng, Xu Pan, Ya Liu, Jun Du, Ying Li, Zhi-ying Liu, Bing-lan Xie, Zhi-jian Kuang, Jia Yi*, Wen Liu*. CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development. Nucleic Acids Res. 2024 10.1093/nar/gkae329. (*共同通讯作者)
9、Qi-Xuan Huang, Da-Meng Fan, Zao-Zao Zheng, Ting Ran, Ao Bai, Rong-Quan Xiao, Guo-Sheng Hu, Wen Liu*. Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo, J Med Chem. 2024 Apr 25;67(8):6658-6672. doi: 10.1021/acs.jmedchem.4c00141. PMCID: PMC11056977 (*通讯作者)
10、Shi-qiang Cao, Song-tao Xue, Wen-juan Li, Guo-sheng Hu, Zhi-gang Wu, Jian-cong Zheng, Shu-liang Zhang, Xiao Lin, Chun Chen*, Wen Liu*, Bin Zheng*. CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma, Cell Death Discovery. 2024 Mar 2;10(1):110. doi: 10.1038/s41420-024-01881-z. Epub 2024 Mar 2.(*共同通讯作者)
11、Song-tao Xue, Shi-qiang Cao, Jian-cheng Ding, Wen-juan Li, Guo-sheng Hu, Jian-cong Zheng, Xiao Lin, Chun Chen*, Wen Liu*, Bin Zheng*. LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis. Cellular and molecular life sciences. 2024 Mar 8;81(1):121. doi: 10.1007/s00018-024-05172-9. Epub 2024 Mar 8. (*共同通讯作者)
12、Xiao-Nan Wu, Jia-yuan Li, Qi He, Bo-qun Li, Yao-hui He, Xu Pan, Ming-yue Wang, Rui Sang, Jian-cheng Ding, Xiang Gao, Zhen Wu*, Wen Liu*. Targeting the PHF8/YY1 Axis Suppresses Cancer Cell Growth Through Modulation of ROS. PNAS. 2024 Jan 9;121(2):e2219352120. doi: 10.1073/pnas.2219352120. Epub 2024 Jan 2. (*共同通讯作者)
13、Kuang Z, Guo K, Cao Y, Jiang M, Wang C, Wu Q, Hu G, Ao M, Huang M, Qin J, Zhao T, Lu S, Sun C, Li M, Wu T*, Liu W*, Fang M*. The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer. 2023 Dec;129(12):1915-1929. doi: 10.1038/s41416-023-02464-y. Epub 2023 Oct 26. PMID: 37884683; PMCID: PMC10703862. (*共同通讯作者)
14、Li WJ, Huang Y, Lin YA, Zhang BD, Li MY, Zou YQ, Hu GS, He YH, Yang JJ, Xie BL, Huang HH, Deng X*, Liu W*. Targeting PRMT1-mediated SRSF1 methylation to suppress oncogenic exon inclusion events and breast tumorigenesis. Cell Rep. 2023 Nov 28;42(11):113385. doi: 10.1016/j.celrep.2023.113385. Epub 2023 Nov 8. PMID: 37938975. (*共同通讯作者)
15、Lu X, Peng L, Ding J, Li Y, Li Q, Rao M, Shu T, He X, Liu C, Ye J, Liu W*, You H*. A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy. Proc Natl Acad Sci U S A. 2023 Oct 10;120(41):e2304534120. doi: 10.1073/pnas.2304534120. Epub 2023 Oct 2. PMID: 37782793; PMCID: PMC10576145. (*共同通讯作者)
16、Shi TT, Huang Y, Li Y, Dai XL, He YH, Ding JC, Ran T, Shi Y, Yuan Q, Li WJ*, Liu W*. MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion. Sci Adv. 2023 Sep;9(35):eadg7053. doi: 10.1126/sciadv.adg7053. Epub 2023 Sep 1. PMID: 37656786. (*共同通讯作者)
17、 Li D, Wang W, Liu B, Jin D, Wang Y, He G, Guo L, Liu W*, Li Y*. Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis. Cell Death Discov. 2023 Aug 10;9(1):294. doi: 10.1038/s41420-023-01593-w. PMID: 37563132; PMCID: PMC10415397. (*共同通讯作者)
18、Chen X, Ding JC, Hu GS, Shu XY, Liu Y, Du J, Wen ZJ, Liu JY, Huang HH, Tang GH, Liu W. Estrogen-Induced LncRNA, LINC02568, promotes estrogen receptor-positive breast cancer development and drug resistance through both in trans and in cis mechanisms. Adv Sci (Weinh). 2023 Jul 5:e2206663. doi: 10.1002/advs.202206663. Epub ahead of print. PMID: 37404090. (通讯作者)
19、Ding N, You AB., Yang H, Hu GS, Lai CP, Liu W*, Ye F*. A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer. Clin Cancer Res. 2023 Jun 1, 29(11):2095-2109.doi: 10.1158/1078-0432.CCR-22-3836. PMID: 36951687; PMCID: PMC10233356.
20、Yi J, Wang L, Du J, Wang M, Shen H, Liu Z, Qin Y, Liu J, Hu G, Xiao R, Ding J, Chen X, Wang H, Huang H, Ouyang G*, Liu W*. ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer. Dev Cell. 2023 Apr 6:S1534-5807(23)00131-4. doi: 10.1016/j.devcel.2023.03.015. Epub ahead of print. PMID: 37054705. (*共同通讯作者)
21、Yi J, Wang L, Hu GS, Zhang YY, Du J, Ding JC, Ji X, Shen HF, Huang HH, Ye F*, Liu W*. CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS. EMBO J. 2023 Apr 3:e112408. doi: 10.15252/embj.2022112408. Epub ahead of print. PMID: 37009655. (*共同通讯作者)
22、Xia L, Yuan LZ, Hu YH, Liu JY, Hu GS, Qi RY, Zhang TY, Xiong HL, Zheng ZZ, Lin HW, Zhang JM, Yu C, Zhou M, Ma J, Cheng T, Chen RR, Guan Y, Xia NS*, Liu W*. A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19. Cell Mol Immunol. 2023 Apr;20(4):351-364. doi: 10.1038/s41423-023-00985-3. Epub 2023 Mar 2. PMID: 36864189; PMCID: PMC9979130. (*共同通讯作者)
23、Hu GS, Zheng ZZ, He YH, Wang DC, Liu W. CPPA: A Web Tool for Exploring Proteomic and Phosphoproteomic Data in Cancer. J Proteome Res. 2023 Feb 3;22(2):368-373. doi: 10.1021/acs.jproteome.2c00512. Epub 2022 Dec 12. PMID: 36507870; PMCID: PMC9904288. (通讯作者)
24、Zheng ZZ, Xia L, Hu GS, Liu JY, Hu YH, Chen YJ, Peng JY, Zhang WJ*, Liu W*. Super-enhancer-controlled positive feedback loop BRD4/ERα-RET-ERα promotes ERα-positive breast cancer. Nucleic Acids Res. 2022 Oct 14;50(18):10230-10248. doi: 10.1093/nar/gkac778. PMID: 36124682; PMCID: PMC9561272. (*共同通讯作者)
25、Xiao RQ, Ran T, Huang QX, Hu GS, Fan DM, Yi J, Liu W. A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2200753119. doi: 10.1073/pnas.2200753119. Epub 2022 Aug 15. PMID: 35969736; PMCID: PMC9407455. (通讯作者)
26、Songtao Xue, Bin Zheng, Shiqiang Cao, Jiancheng Ding, Guosheng Hu, Wen Liu*, Chun Chen*. Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis. Molecular Cancer. 2022. doi:10.1186/s12943-022-01539-3 (⃰ 共同通讯作者)
27、Xian Lin, Xianliang Ke, Xiaoqin Jian, Lin Xia, Yang Yang, Tianying Zhang, Hualong Xiong, Binghai Zhao, Wen Liu*, Quanjiao Chen*, Chong Tang*. Azacytidine targeting SARS-CoV-2 viral RNA as a potential treatment for COVID-19. Science Bulletin. 2022. doi:10.1016/j.scib.2022.02.002. (⃰ 共同通讯作者)
28、Zhaopeng Shi, Guifang Gan, Xiang Xu, Jieying Zhang, Yuan Yuan, Bo Bi, Xianfu Gao, Pengfei Xu, Wenbin Zeng, Jixi Li, Youqiong Ye, Aiwu Zhou, Naixia Zhang, Wen Liu*, Shuhai Lin*, Jun Mi*. Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1. Journal of Hematology & Oncology. 2021 Sep 25;14(1):153. (⃰ 共同通讯作者)
29、Wensheng Liu, Yinan Zhao, Xiaohua Liu, Xiaoya Zhang, Jiancheng Ding, Yang Li, Yingpu Tian, Haibin Wang, Wen Liu*, Zhongxian Lu*. A Novel Meiosis-Related lncRNA, Rbakdn, Contributes to Spermatogenesis by Stabilizing Ptbp2. Frontiers in Genetics. 2021 Oct 11; 12:752495. (⃰ 共同通讯作者)
30、 Liu W, Xie L, He YH, Wu ZY, Liu LX, Bai XF, Deng DX, Xu XE, Liao LD, Lin W, Heng JH, Xu X, Peng L, Huang QF, Li CY, Zhang ZD, Wang W, Zhang GR, Gao X, Wang SH, Li CQ, Xu LY*, Liu W*, Li EM*. Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting. Nature Communications. 2021 Aug 16;12(1):4961. (⃰ 共同通讯作者)
31、Lin XT, Zhuang SW, Chen X, Du J, Zhong LH, Ding JC, Wang L, Yi J, Hu GS, Tang GH, Luo X*, Liu W*, Ye F*. LncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. Molecular Therapy. 2022 Feb 2;30(2):688-702. (⃰ 共同通讯作者)
32、 Xia L, Liu JY, Zheng ZZ, Chen YJ, Ding JC, Hu YH, Hu GS, Xia NS, Liu W. BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma. Molecular Therapy. 2021 Oct 6;29(10):3011-3026. (通讯作者)
33、Jiang MX, Kuang ZJ, He YH, Cao Y, Yu TY, Chen JD*, Liu W*, Wang W*. SNAPIN regulates cell cycle progression to promote pancreatic β cell growth. Frontiers in Endocrinology. 2021 Jun 14;12:624309. (⃰ 共同通讯作者)
34、Xia L, Zheng ZZ, Liu JY, Chen YJ, Ding JC, Hu GS, Liu SL, Luo WX, Xia NS, Liu W. Targeting triple negative breast cancer with combination therapy of epidermal growth factor receptor-targeted chimeric antigen receptor T cell and CDK7 inhibitor. Cancer Immunology Research. 2021 Jun;9(6):707-722.(通讯作者)
35、Li WJ, He YH, Yang JJ, Hu GS, Lin YA, Ran T, Peng BL, Xie BL, Huang MF, Gao X, Huang HH, Zhu HH, Ye F, Liu W. Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth. Nature Communications. 2021 Mar 29;12(1):1946.(通讯作者)
36、Shen HF, Zhang WJ, Huang Y, He YH, Hu GS, Wang L, Peng BL, Yi J, Li TT, Rong R, Chen XY, Liu JY, Li WJ, Ohgi K, Li SW, Rosenfeld MG, Liu W.The dual function of KDM5C in both gene transcriptional activation and repression promotes breast cancer cell growth and tumorigenesis. Advanced Science. 2021 Feb 18;8(9):2004635.(通讯作者)
37、Wang L, Yi j, Lu LY, Zhang YY, Wang L, Hu GS, Liu YC, Ding JC, Shen HF, Zhao FQ, Huang HH, Liu W. Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes. Theranostics . 2021 Jan 1; 11(4): 1732-1752.(通讯作者)
38、Xia L, Zheng ZZ, Liu JY, Chen YJ, Ding JC, Xia NX, Luo WX*, Liu W*. EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo. Clinical & Translational Immunology 2020 May 3;9(5):e01135. (⃰ 共同通讯作者)
39、Peng BL, Li WJ, Ding JC, He YH, Ran T, Xie BL, Wang ZR, Shen HF, Xiao RQ, Gao WW, Ye TY, Gao X, Liu W. A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor a-dependent transcriptional activation and breast carcinogenesis. Theranostics 2020 Feb 10; 10(8): 3451-3473. (通讯作者)
40、Tang GH, Chen X, Ding JC, Du J, Lin XT, Xia L, Lian JB, Ye F*, He XS*, Liu W*. LncRNA LUCRC Regulates Colorectal Cancer Cell Growth and Tumorigenesis by Targeting Endoplasmic Reticulum Stress Response. Frontiers in Genetics 2020 Jan 31;10:1409. ( ⃰ 共同通讯作者)
41、Ran T, Xiao RQ, Huang QX, Yuan HL, Lu T, Liu W. In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment. ACS Med. Chem. Lett. 2019, Nov 19, 10(12):1609−1613. ( ⃰通讯作者)
42、Lin BQ, An Y, Meng LY, Zhang HM, Song J, Zhu Z, Liu W*, Song YL*, Yang CY*. Control of CRISPR-Cas9 with small molecule-activated allosteric aptamer regulating sgRNAs. Chem. Commun. 2019 Oct 8;55(81):12223-12226. ( ⃰共同通讯作者)
43、Chen CH, Yang N, Zhang YC, Ding JC, Zhang WJ, Liu R, Liu W*, Chen CS*. Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers. Int. J. Biol. Sci. 2019 Jun 10;15(8) :1733–1742. (共同通讯作者)
44、Li Y, Liu WS, Yi J, Kong SB, Ding JC, Zhao YN, Tian YP, Feng GS, Li CJ, Liu W*, Wang HB, Lu ZX*. The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis. Asian Journal of Andrology. 2020 Jan-Feb; 22(1):79–87.(共同通讯作者)
45、Ran T, Li WJ, Peng BL, Xie BL, Lu T, Lu S*, Liu W*. Virtual Screening with Structure-based Pharmacophore Model to Identify Small-molecule Inhibitors of CARM1. J Chem Inf Model . 2019 Jan 28;59(1):522-534. (*共同通讯作者)
46、Gao WW, Xiao RQ, Zhang WJ, Hu YR, Peng BL, Li WJ, He YH, Shen HF, Ding JC, Huang QX, Ye TY, Li Y, Liu ZY, Ding R, Rosenfeld MG, Liu W. JMJD6 licenses estrogen receptor a-dependent enhancer and coding gene activation by modulating the recruitment of the CARM1/MED12 co-activator complex. Mol Cell 2018 Apr 19;70(2):340-357.e8. (通讯作者)
47、Wu XN, Shi TT, He YH, Wang FF, Sang R, Ding JC, Zhang WJ, Shu XY, Shen HF, Yi J, Gao X, Liu W. Methylation of transcription factor YY2 regulates its transcriptional activity and cell proliferation. Cell Discov. 2017 Oct 3;3:17035.（通讯作者）
48、Yi J, Shen HF, Qiu JS, Huang MF, Zhang WJ, Ding JC, Zhu XY, Zhou Y, Fu XD*, Liu W*. JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner. Nucleic Acids Res. 2017 Apr 7;45(6):3503-3518. ( ⃰共同通讯作者)
49、Zhang WJ, Wu XN, Shi TT, Xu HT, Yia J, Shen HF, Huang MF, Shu XY, Wang FF, Peng BL, Xiao RQ, Gao WW, Ding JC, Liu W. Regulation of transcription factor Yin Yang 1 by SET7/9-mediated lysine methylation. Sci Rep. 2016 Feb 23;6:21718.（通讯作者）
50、Gao WW, Xiao RQ, Peng BL, Xu HT, Shen HF, Huang MF, Shi TT, Yi J, Zhang WJ, Wu XN, Gao X, Lin XZ, Dorrestein PC, Rosenfeld MG*, Liu W*. Arginine methylation of HSP70 regulates retinoid acid-mediated RARβ2 gene activation. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3327-36. ( ⃰共同通讯作者)
51、Liu W ⃰ #，Ma Q#, Wong K, Li W, Ohgi K, Zhang J, Aggarwal AK, Rosenfeld MG ⃰. Brd4 and JMJD6-associated anti-Pause enhancers in regulation of transcriptional pause release. Cell. 2013 Dec 19;155(7):1581-1595. ( ⃰ 共同通讯作者，#共同第一作者).
52、Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22; 466(7305):508-12.（第一作者）
53、Zhou H #, Liu W#, Su Y, Wei Z, Liu J, Kolluri S.K., Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li W.G., Lin B, Zhang H.P., Yu J, Luo S.P., Zeng JZ, Duester G, Huang PQ, Zhang XK NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73. ( #共同通讯作者)