Education

2000–2004,School of Life Sciences, Xiamen University, Bachelor

2004–2009, Center for Excellence in Molecular Cell Science(CAS), Ph.D.

Professional Experience

2009-2012, University of California,Los Angeles(UCLA),Postdoctoral Fellow

2014-2015, Mayo Clinic, Visiting Scholar

2012.11 – 2018.10, School of Life Sciences, Xiamen University, Associate Professor

2018.11-now,School of Life Sciences, Xiamen University, Professor

Selected Publications (*Corresponding author, #co-first author)

1.Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Martens YA, Shinohara M, Liu CC, Du D, Sun H, Wen L, Xu H, Bu G, Chen XF (2019). Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model. Nat Commun. DOI: 10.1038/s41467-019-09118-9.
2.Sun F, Chronis C, Kronenberg M, Chen XF, Su T, Lay FD, Plath K, Kurdistani SK, Carey MF (2019). Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods. Mol Cell. 73(2):250-263.e5.
3.Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF (2018). Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular Neurodegeneration. 13(1):15.
4.Zhong L*,Chen XF*,§, Wang TT, Wang Z, Liao CY, Wang ZQ, Huang RZ, Wang DX, Li XX, Wu LB, Zheng HH, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer, Xu H, Bu G§ (2017). Soluble TREM2 promotes microglial survival and induces inflammatory responses via distinct signaling pathways. J Exp Med. 214(3):597-607. (*co-first author; §corresponding author)
5.Zhong L, Zhang ZL, Li XX, Liao CY, Mou PF, Wang TT, Wang ZQ, Wang Z, Wei M, Xu H, Bu G, Chen XF (2017). TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Front.Aging Neurosci. 9:204.
6.Yang L*, Liu CC*, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF§, Bu G§(2016). LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. J Neuroinflammation. 13(1):304.
7.Kang RR, Li P, Wang TT, Li XX, Wei ZC, Zhang ZL, Zhong L, Cao LL, Heckman MG, Zhang YW, Xu H, Huang CM, Bu G, Chen XF (2016). Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population. Scientific Reports6:19930.
8.Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF (2016). A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Molecular Neurodegeneration. 11(1):2.
9.Zhong L*,Chen XF*,§, Zhang ZL, Wang Z, Shi XZ, Xu K, Zhang YW, Xu H, Bu G§ (2015). DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response. J Biol Chem. 290(25):15866-77.
10. Chen XF§, Zhang YW, Xu H, Bu G§. (2013). Transcriptional regulation and its misregulation in Alzheimer's disease. Molecular Brain. 6(1):44-53.
11. Chen XF, Lehmann L., Lin J., Vashisht A., Schmidt, Ferrari R., Huang CY., McKee R., Mosley A., Plath K., Kurdistani S., Wohlschlegel J., Carey M.§(2012). Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function. Cell Reports2:1061-1067.
12. Chen XF, Kuryan B., Kitada T., Tran N., Li B., Carey M. (2012). The Rpd3 Core Complex is a Chromatin Stabilization Module. Current Biology22(1):1-8.
13. Chen XF, Meng FL, Zhou JQ (2009). Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae. PLoS Genetics5(6): e1000535.