Education

1990, M.Sc., Xiamen University;

1996, Ph.D., Xiamen University.

Professional Experience

1993-1996, Assistant Professor, Department of Biology, Xiamen University;

1995-1996, 1999: Visiting Scholar, The Burnham Institute, CA, USA;

1997-2000, Associate Professor, Department of Biology, Xiamen University;

2001-Present, Professor, School of Life Sciences, Xiamen University.

Research Area

1. Nuclear receptors and their roles in cell proliferation and cell death;
2. Nuclear receptor associated interactions, protein modifications, and regulatory pathways;
3. Molecular basis of nuclear receptor function in tumor, diabetes, obesity and inflammation;
4. Nuclear receptors as the target for the design and development of therapeutics to treat cancerous and metabolic diseases.

Selected Publications

1. Ai YL^#, Wang WJ^#*, Liu FJ^#, Fang W^#, Chen HZ, Wu LZ, Hong XH^*, Zhu YK, Zhang CX, Liu LY, Hong WB, Zhou B, Chen QT, Wu Q^*. Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P. Cell Research.2023; 33(12):904-922
2. Zhang ZY^#, Ju CY^#, Wu LZ^#, Yan H^#, Hong WB^#, Chen HZ, Yang PB, Wang BR, Gou T, Chen XY, Jiang ZH, Wang WJ, Lin T^*, Li FN^*, Wu Q^*. Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein. Cell Chemical Biology. 2023;30(3):261-277 e8.
3. Chen QT^#, Zhang ZY^#, Huang QL^#, Chen HZ^#*, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q^*. HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma. Nature Metabolism. 2022;4(10):1306-1321.
4. Zhang JY^#, Zhou B^#, Sun RY^#, Ai YL^#, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ^*, Wu Q^*. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Research. 2021;31(9):980-997.
5. Yang PB^#, Hou PP^#, Liu FY^#, Hong WB^#, Chen HZ^#, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Zhou JX, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T^* , Wu Q^*. Blocking PPARgamma interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. PNAS. 2020;117(44):27412-27422.
6. Hou PP^#, Luo LJ^#, Chen HZ^#, Chen QT^#, Bian XL^#, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen Q, Zhou D, Wu Q^*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. Molecular Cell. 2020;78(6):1192-1206 e1110.
7. Zhou B^#, Zhang JY^#, Liu XS^#, Chen HZ^#, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q^*. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Research. 2018;28(12):1171-1185.
8. Li XX^#, Wang ZJ^#, Zheng Y^#, Guan YF^#, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q^*, Chen HZ^*. Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation. Molecular Cell. 2018;69(3):480-492 e487.
9. Bian XL^#, Chen HZ^#, Yang PB^#, Li YP^#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q^*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017;8:14420.
10. Li L^#, Liu Y^#, Chen HZ^#, Li FW^#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T^*, Wu Q^*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015;11(5):339-346.
11. Wang WJ^#, Wang Y^#, Chen HZ^#, Xing YZ^#, Li FW^#, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann F, Wu M, Han J, Huang PQ, Lin T^*, Wu Q^*. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nature Chemical Biology. 2014;10(2):133-140.
12. Zhan YY^#, Chen Y^#, Zhang Q^#, Zhuang JJ^#, Tian M, Chen HZ, Zhang LR, Zhang HK, He JP, Wang WJ, Wu R, Wang Y, Shi C, Yang K, Li AZ, Xin YZ, Li TY, Yang JY, Zheng ZH, Yu CD, Lin SC, Chang C, Huang PQ, Lin T^*, Wu Q^*. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nature Chemical Biology. 2012;8(11):897-904.
13. Zhan YY^#, Du XP^#, Chen HZ, Liu JJ, Zhao BX, Huang DH, Li GD, Xu QY, Zhang MQ, Weimer BC, Chen D, Cheng Z, Zhang LR, Li QX, Li SW, Zheng ZH, Song SY, Huang YJ, Ye ZY, Su WJ, Lin SC^*, Shen YM^*, Wu Q^*. Cytosporone B is an agonist for nuclear orphan receptor Nur77. Nature Chemical Biology. 2008;4(9):548-556.