Nengming Xiao, Ph.D. Professor. Tel: +86-592-2880352 E-mail: nengming@xmu.edu.cn

Education

2000, B.Sc., Beijing Normal University;

2006, Ph.D., Peking University.

Professional Experience

2006-2009, Postdoctoral Fellow, The Scripps Research Institute, La Jolla, California, USA;

2009-2010, Postdoctoral Fellow, Cleveland Clinic, Cleveland, Ohio, USA;

2010-2014, Postdoctoral Fellow, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA;

2014-present, Professor, School of Life Sciences, Xiamen University, Xiamen, China.

Research Area

To investigate molecular mechanism underlying activation and differentiation of T cells (including Follicular helper T cells, Cytotoxic T cells, Regulatory T cells), and their roles in antiviral and antitumor immune responses as well as autoimmune diseases.

Selected Publications

1. Wang Y^#, Zhang Q^#, He T, Wang Y, Lu T, Wang Z, Wang Y, Lin S, Yang K, Wang X, Xie J, Zhou Y, Hong Y, Liu WH, Mao K, Cheng SC, Chen X, Li Q*, Xiao N*. The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells. Nature Communications. 2023 Oct 20;14(1):6639. doi: 10.1038/s41467-023-42428-7.

2. Chen Q, Zhuang S, Hong Y, Yang L, Guo P, Mo P, Peng K*, Li W*, Xiao N*, Yu C*. Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. Oncogene. 2022 Mar;41(10):1421-1433. doi: 10.1038/s41388-021-02173-x.

3. Zhai X^#, Liu K^#, Fang H^#, Zhang Q, Gao X, Liu F, Zhou S, Wang X, Niu Y, Hong Y, Lin SH, Liu WH, Xiao C, Li Q*, Xiao N*. Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming. Science Advances. 2021 Dec 3;7(49):eabk0490. doi: 10.1126/sciadv.abk0490.

4. Yang L^#, Chen W^#*, Li L, Xiao Y, Fan S, Zhang Q, Xia T, Li M, Hong Y, Zhao T, Li Q, Liu WH*, Xiao N*. Ddb1 Is Essential for the Expansion of CD4 + Helper T Cells by Regulating Cell Cycle Progression and Cell Death. Front Immunol. 2021 Aug 30;12:722273. doi: 10.3389/fimmu.2021.722273.

5. Xiao N^#, Eto D, Elly C, Peng G, Crotty S*, Liu YC*. The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Nat Immunol. 2014 Jul;15(7):657-66. doi: 10.1038/ni.2912.

6. Siggs OM^#,, Xiao N^#, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B*. iRhom2 is required for the secretion of mouse TNFα. Blood. 2012 Jun 14;119(24):5769-71.

7. Xiao N^#, Eidenschenk C, Krebs P, Brandl K, Blasius AL, Xia Y, Khovananth K, Smart NG, Beutler B*. The Tpl2 mutation sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol. 2009 Dec 15;183(12):7975-83.

8. Xu L^#, Xiao N^#, Liu F, Ren H, Gu J*. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1530-5.