Education

2002, B.Sc., China Agricultural University;

2007, Ph.D., China Agricultural University.

Professional Experience

2007-2012, Postdoc, NIH, USA;

2012-present, Professor, School of Life Science, Xiamen University.

Research Area

Malaria remain one of most serious public health thread in the world, causing billions infection cases and millions death cases annually. Because of the lack of the effective vaccine and quick evolving and spreading globally of drug resistant parasite strains, we face the challenge for preventing and controlling malaria globally. Research in our group focus one two area: 1. Identify and characterize the genetic determinants conferring drug resistance in human malaria parasite, study the molecular and cellular mechanism regulating the drug resistance; 2. Based on the mouse malaria parasite model, investigate the signal pathway involved in the hepatocyte invasion and development of parasite sporozoite, we are particularly interested in identifying the host factors and their interaction with parasite factors during the parasite invasion and development in the host cell.

Selected Publications

20.Bing Liu^#,  Cong Liu^#,  Zhenkui Li^#, Wenjia Liu, Huiting Cui^* and Jing Yuan^*.A subpellicular microtubule dynein transport machinery regulates ookinete morphogenesis for mosquito transmission of Plasmodium yoelii.Nature Communications, (2024)
19.Jiepeng Guan^#,  Peijia Wu,  Xiaoli Mo, Xiaolong Zhang, Wenqi Liang , Xiaoming Zhang, Lubin jiang^* , Jian Li^*, Huiting Cui, Jing Yuan^*.An axonemal intron splicing program sustains Plasmodium male development.Nature Communications, (2024)
18.Ruixue Xu^#, Lirong Lini^#,  Zhiwei Jiao, Rui Liang, Yazhen Guo , Yixin Zhang, Xiaoxu Shang , Yuezhou Wang , Xu Wang , Luming Yao , Shengfa Liu , Xianming Deng , Jing Yuan^* , Xin-Zhuan^* , Jian Li^*.Deaggregation of mutant Plasmodium yoelii de-ubiquitinase UBP1 alters MDR1 localization to confer multidrug resistance.Nature Communications, (2024)
17.Shuzhen Yang^#, Mengya Cai^#, Junjie Huang^#,  Shengnan Zhang, Xiaoli Mo , Kai Jiang^*, Huiting Cui^* and Jing Yuan^*EB1 decoration of microtubule lattice facilitates spindle-kinetochore lateral attachment in Plasmodium male gametogenesis.Nature Communications, (2023)
16.Pengge Qian^#, Xu Wang^#, Cuirong Guan^#,  Xin Fang, Mengya Cai, Chuan-qi Zhong, Yong Cui, Yanbin Li, Luming Yao, Huiting Cui^*, Kai Jiang^* and Jing Yuan^*Apical anchorage and stabilization of subpellicular microtubules by apical polar ring ensures Plasmodium ookinete infection in mosquito.Nature Communications, (2022)
15.Pengge Qian^#, Xu Wang^#, Chuan-Qi Zhong^#, Jiaxu Wang^#, Mengya Cai, Wang Nguitragool, Jian Li^*,Huiting Cui^* and Jing Yuan^*Inner membrane complex proteomics reveals a palmitoylation regulation critical for intraerythrocytic development of malaria parasite. eLife, (2022)
14.Meng Liu^#, Gangqiang Guo^#, Pengge Qian^#, Jianbing Mu^#, Binbin Lu, Xiaoqin He, Yanting Fan, Xiaomin Shang, Guang Yang, Shijun Shen, Wenju Liu, Liping Wang, Liang Gu, Quankai Mu, Xinyu Yu, Yuemeng Zhao, Richard Culleton, Jun Cao, Lubin Jiang, Thomas E Wellems^*, Jing Yuan^*, Cizhong Jiang^* and Qingfeng Zhang^*.5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes.PNAS, (2022)
13.Zhenke Yang^#, Yang Shi^#, Huiting Cui^#, Shuzhen Yang, Han Gao and Jing Yuan^*.A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission.Science Advances, (2021)
12.Zhenkui Li^#, Huiting Cui^#, Jiepeng Guan, Cong Liu, Zhengang Yang and Jing Yuan^*.Plasmodium transcription repressor AP2‐O3 regulates sex‐specific identity of gene expression in female gametocytes.EMBO Reports, (2021)
11.Chuanyuan Liu^#, Zhenke Yang^#, Mengya Cai, Yang Shi, Huiting Cui and Jing Yuan^*.Generation of Plasmodium yoelii malaria parasite for conditional degradation of proteins.Molecular & Biochemical Parasitology, 2021
10.Xu Wang^#, Pengge Qian^#, Huiting Cui^#, Luming Yao and Jing Yuan^*.A protein palmitoylation cascade regulates microtubule cytoskeleton integrity in Plasmodium.The EMBO Journal, (2020)
9.Yuanyuan Jiang^#, Jun Wei^#, Huiting Cui^#, Chuanyuan Liu, Yuan Zhi, ZhengZheng Jiang, Zhenkui Li, Shaoneng Li, Zhenke Yang, Xu Wang, Pengge Qian, Cui Zhang, Chuanqi Zhong, Xinzhuan Su and Jing Yuan^*.An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites.Nature Communications, 2020
8.Han Gao^#, Zhenke Yang^#, Xu Wang^#, Pengge Qian, Renjie Hong, Xin Chen, Xinzhuan Su, Huiting Cui and Jing Yuan^*.ISP1-anchored polarization of GCβ/CDC50A complex initiates malaria ookinete gliding motility.Current Biology, 2018
7.Cong Liu^#, Zhenkui Li^#, Yuanyuan Jiang, Huiting Cui^* and Jing Yuan^*.Generation of Plasmodium yoelii malaria parasite carrying double fluorescence reporters in gametocytes.Molecular & Biochemical Parasitology, 2018
6.Pengge Qian^#, Xu Wang^#, Zhenke Yang, Zhenkui Li, Han Gao, XinZhuan Su, Huiting Cui^* and Jing Yuan^*.A Cas9 transgenic Plasmodium yoelii parasite for efficient gene editing.Molecular & Biochemical Parasitology. , 2018
5.Cui Zhang^#, Zhenkui Li^#, Huiting Cui^#, Yuanyuan Jiang, Zhenke Yang, Xu Wang, Han Gao, Cong Liu, Shujia Zhang, XinZhuan Su^* and Jing Yuan^*.Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development.mBio, 2017
4.Cui Zhang^#, Han Gao^#, Zhenke Yang, Yuanyuan Jiang, Zhenkui Li, Xu Wang, Bo Xiao, XinZhuan Su, Huiting Cui^* and Jing Yuan^*.CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii.Molecular & Biochemical Parasitology, 2017
3.Cui Zhang^#, Bo Xiao^#, Yuanyuan Jiang^#, Yihua Zhao^#, Zhenkui Li, Han Gao, Yuan Ling, Jun Wei, Shaoneng Li, Mingke Lu, XinZhuan Su, Huiting Cui^* and Jing Yuan^*.Efficient Editing of Malaria Parasite Genome Using the CRISPR/Cas9 System.mBio, 2014
2.Jing Yuan^#, Ken Chih -Chien Cheng^#, Ronald Johnson, Ruili Huang, Sittiporn Pattaradilokrat, Anna Liu, Rajarshi Guha, David Fidock, James Inglese, Thomas E Wellems, Christopher Austin^* and Xinzhuan Su^*.Chemical genomic profiling for antimalarial therapies, response signatures and molecular targets.Science, 2011Research article and Cover; Recommended “Exceptional” by “Faculty of 1000 Biology”
1.Jing Yuan^#, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin and Xinzhuan Su^*.Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.Nature Chemical Biology, 2009