Education

B.S. 2009-2014, School of Basic Medical Sciences, Peking University;
Ph.D. 2014-2017, School of Basic Medical Sciences, Peking University;

Professional Experience

Postdoctoral Fellow 2017-2020, School of Basic Medical Sciences, Peking University;
Assistant Professor 2020 - present, School of Life Sciences, Xiamen University;

Selected Publications (*Corresponding author, #co-first author)

1. Chen J^#*, Lin X^#, Xiang W, Chen Y, Zhao Y, Huang L, Liu L^*. DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems. Nucleic Acids Research. 2024 Dec 16:gkae1241. doi: 10.1093/nar/gkae1241.
2. Chen J^#, Chen Y^#, Huang L^#, Lin X, Chen H, Xiang W, Liang Liu^*. Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. Nature Biotechnology. 2024; doi: 10.1038/s41587-024-02255-7.
3. Chen J^#, Chen H^#, Li S^#, Lin X, Hu R, Zhang K^*, Liu L^*. Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery. eLife. 2024; 12:RP86847.
4. Chen J^#, Hu R^#, Chen Y^#, Lin X^#, Xiang W, Chen H, Yao C, Liu L^*. Structural basis for MTA1c-mediated DNA N6-adenine methylation. Nature Communications. 2022; 13(1):3257.
5. Wang J^#, Chen J^#, Wu G^#, Zhang H^#, Du X^#, Chen S, Zhang L, Wang K, Wu X, Gao S, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y^*, Li J^*, Yun C^*, Cheng H^*. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes & Development. 2019 May 1;33(9-10):536-549.
6. Chen J, Liu L, Cao C, Li M, Tan K, Yang X, Yun C^*. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Scientific Reports. 2016 Aug 23:6:31425.
7. Liu L^#, Chen J^#, Yang B, Wang F, Wang Y^*, Yun C^*. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function. Structure. 2015 Nov 3;23(11):2066-75.
8. Zhao P, Yao M, Zhu S, Chen J, Yun C^*. Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem Biophys Res Commun. 2018 Jul 20;502(3):332-337.
9. Shi Y, Fan S, Wang D, Huyan T, Chen J, Chen J, Su J, Li X, Wang Z, Xie S, Yun C, Li X, Tie L^*. FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission. Biochim Biophys Acta. 2018 Jul;1864(7):2481-2494.
10. Liu F^#, Wang B^#, Wang Q^#, Qi Z^#, Chen C^#, Kong L^#, Chen J, Liu X, Wang A, Hu C, Wang W, Wang H, Wu F, Ruan Y, Qi S, Liu J, Zou F, Hu Z, Wang W, Wang L, Zhang S, Yun C^*, Zhai Z^*, Liu J^*, Liu Q^*. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget. 2016 Jul 19;7(29):45562-45574.
11. Liu L, Chen J, Yang B, Wang Y^*. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem Biophys Res Commun. 2015 Mar 6;458(2):429-34.
12. Liu L, Chen J, Yang B, Wang Y^*. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions. FEBS Open Bio. 2015 Mar 5:5:155-62.