Education

B.S. 2014, Xiamen University, Biological Sciences;
Ph.D. 2021, California Institute of Technology, Biology and Bioengineering

Professional Experience

Assistant Professor, 2022 – present, Xiamen University.

Research Area

The Hippo signaling pathway represents a central mechanism governing organ size during animal development and regeneration, while also playing a crucial role in the regulation of innate immunity. By applying genetics, cell biology, biochemistry and molecular biology approaches, our research group investigates the modulatory functions and molecular mechanisms of the Hippo signaling pathway in immune and inflammatory responses across various cellular and animal models, including Drosophila and mice.

Selected Publications 

1.Yang, Y., Zhou, H., Huang, X. et al. Innate immune and proinflammatory signals activate the Hippo pathway via a Tak1-STRIPAK-Tao axis. Nat Commun 15, 145 (2024).
2.Huang, Xiawei, Hongmiao Hu, Alexandre Webster, Fan Zou, Jiamu Du, Dinshaw J. Patel, Ravi Sachidanandam, Katalin Fejes Toth, Alexei A. Aravin, and Sisi Li. "Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex." Nature Communications 12, no. 1 (2021): 4061.
3.Huang, Xiawei, Katalin Fejes Tóth, and Alexei A. Aravin. "piRNA Biogenesis in Drosophila melanogaster." Trends in Genetics 33, no. 11 (2017): 882-894.