Education

2010-2014, Xiamen University, Biological Science,B.S.
2014-2019,Tsinghua University, Biology,Ph.D.

Professional Experience

2019-2020, Westlake University,Research assistant
2021-2023,Westlake University,Postdoctoral Fellow  
2023-Present,School of Life Sciences, Xiamen University,Associate Professor

Research Area

We mainly focus on structural analysis and functional mechanism research of membrane proteins and protein complexes by cryo-electron microscopy. On the one hand, we utilize our strengths in membrane protein purification and sample preparation to explore the structures and regulatory mechanisms of membrane proteins related to major human diseases, especially neurological diseases; on the other hand, we will collaborate with other scientists to explain structure mechanisms of cellular stress biology, and facilitate the development of novel drugs.

Selected Publications (*Corresponding author, #co-first author)

[1]Gong D^#,^*, Chi X^#, Wei J^#, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen SRW^*, Yan N^*. Modulation of cardiac ryanodine receptor 2 by calmodulin. Nature, 2019, 572: 347-351, doi:10.1038/s41586-019-1377-y
[2]Chi X^#, Li X^#, Chen Y^#, Zhang Y, Su Q, Zhou Q^*. Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters. Cell Res, 2021, 31: 482-484, doi:10.1038/s41422-020-00437-x
[3]Chi X^#, Fan Q^#, Zhang Y^#, Liang K, Wan L, Zhou Q^*, Li Y^*. Structural mechanism of phospholipids translocation by MlaFEDB complex. Cell Res, 2020, 30: 1127-1135, doi:10.1038/s41422-020-00404-6
[4]Chi X^#, Gong D^#,^*, Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N^*. Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators. Proc Natl Acad Sci U S A, 2019, 116: 25575-25582, doi:10.1073/pnas.1914451116
[5]Gong D^#, Chi X^#, Ren K^#, Huang G, Zhou G, Yan N, Lei J, Zhou Q^*. Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin. Nat Commun, 2018, 9: 3623, doi:10.1038/s41467-018-06075-7
[6]Xie T^#, Chi X^#, Huang B, Ye F, Zhou Q^*, Huang J^*. Rational exploration of fold atlas for human solute carrier proteins. Structure, 2022, 10.1016/j.str.2022.05.015
[7]Chi X^#, Jin X^#, Chen Y^#, Lu X^#, Tu X, Li X, Zhang Y, Lei J, Huang J, Huang Z^*, Zhou Q^*, Pan X^*. Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence. Cell Discov, 2020, 6: 55, doi:10.1038/s41421-020-00193-7
[8] Chi X^#, Xia L^#, Zhang G^#, Chi X^#, Huang B^#, Zhang Y^#, Chen Z^#, Han J, Wu L, Li Z, Sun H, Huang P, Yu C^*, Chen W^*, Zhou Q^*. Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against sars-cov-2 omicron variants. Cell Discov, 2023, 9: 37, doi:10.1038/s41421-023-00535-1