Education

B.S. Polymer Material and Engineering, Sun Yat-Sen University, 2014;
Ph.D. Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 2019

Professional Experience

Postdoctoral Fellow, Cornell University, Weill Cornell Medicine, 2019-2024;
Professor, School of Life Sciences, Xiamen University, 2024

Research Area

Human gut represents the largest immune system within the host. Through long-term co-evolution with the host, the gut microbiota has become an important "invisible organ" which is essential for the human body and acts as an important immune barrier. The functional genes of gut microbes and their corresponding primary/secondary metabolites have a profound impact on host biology, and are closely related to the occurrence and development of a variety of diseases. Also, gut microbiota significantly affects the metabolism of drugs. Our group develop genetic manipulation tools for gut microbiota to investigate the underlying molecular mechanism of the gut microbiome - metabolite/drug - host interactions. 1) Focusing on the gut bacteria-derived metabolites accumulated/depleted within patients with different diseases, our group will explore their impacts on host biology and diseases at the level of molecular mechanism, paving the way for better precision medicine against those diseases; 2) our group will characterize cryptic secondary metabolites produced by gut microbes, and study their effects on the host biology and diseases; 3) we will investigate drug metabolism by gut bacteria, shedding light on the development of new drugs.

Selected Publications

1.Wen-Bing Jin*; Chun-Jun Guo*; Genetic manipulations of nonmodel gut microbes, iMeta, 2024, e216, https://doi.org/10.1002/imt2.216
2.Wen-Bing Jin; Ting-Ting Li; Da Huo; Sophia Qu; Xin V. Li; Mohammad Arifuzzaman; Svetlana F. Lima; Hui-Qing Shi; Aolin Wang; Gregory G. Putzel; Randy S. Longman; David Artis; Chun-Jun Guo*; Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome, Cell, 2022, 185(3): 547-562.e22
3.Wen-Bing Jin; Chun-Jun Guo*; Boosting polyketides production in cell factories, Synthetic and Systems Biotechnology, 2020, 5(1): 35-36
4.Wen-Bing Jin; Sheng Wu; Yi-Fan Xu; Hua Yuan; Gong-Li Tang*; Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions, Natural Product Reports, 2020, 37: 17-28
5.Wen-Bing Jin#; Sheng Wu#; Xiao-Hong Jian; Hua Yuan*; Gong-Li Tang*; A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis, Nature Communications, 2018, 9(1): 2771
6.Wen-Bing Jin; Hua Yuan; Gong-Li Tang*; Strategies for Construction of Cyclopropanes in Natural Products, Chinese Journal of Organic Chemistry, 2018, 38(9): 2324
7.Clarissa Campbell; Peter T.McKenney; Daniel Konstantinovsky; Olga I.Isaeva; Michail Schizas; Jacob Verter; Cheryl Mai; Wen-Bing Jin; Chun-Jun Guo; Sara Violante; Ruben J.Ramos; Justin R.Cross; Krishna Kadaveru; John Hambor; Alexander Y.Rudensky*; Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells, Nature, 2020, 581(7809): 475-479
8.Mohammad Arifuzzaman; Tae Hyung Won; Ting-Ting Li; Hiroshi Yano; Sreehaas Digumarthi; Andrea F. Heras; Wen Zhang; Christopher N. Parkhurst; Sanchita Kashyap; Wen-Bing Jin; Gregory Garbès Putzel; Amy M. Tsou; Coco Chu; Qianru Wei; Alex Grier; Randy Longman; Gregory Sonnenberg; Ellen Scherl; Robbyn Sockolow; Dana Lukin; Robert Battat; Thomas Ciecierega; Aliza Solomon; Elaine Barfield; Kimberley Chien; Johanna Ferreira; Jasmin Williams; Shaira Khan; Peik Sean Chong; Samah Mozumder; Lance Chou; Wenqing Zhou; Anees Ahmed; Connie Zhong; Ann Joseph; Joseph Gladstone; Samantha Jensen; Stefan Worgall; Chun-Jun Guo; Frank C. Schroeder; David Artis*; Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation, Nature, 2022, 611(7936): 578-584
9.Wen Zhang; Mengze Lyu; Nicholas J. Bessman; Zili Xie; Mohammad Arifuzzaman; Hiroshi Yano; Christopher N. Parkhurst; Coco Chu; Lei Zhou; Gregory G. Putzel; Ting-Ting Li; Wen-Bing Jin; Jordan Zhou; Hongzhen Hu; Amy M. Tsou; Chun-Jun Guo; David Artis*; Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection, Cell, 2022, 185(22): 4170-4189.e20
10.Monica Viladomiu; Maeva L. Metz; Svetlana F. Lima; Wen-Bing Jin; Lance Chou; Chun-Jun Guo; Gretchen E. Diehl; Kenneth W. Simpson; Ellen J. Scherl; Randy S. Longman*; Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation, Cell Host & Microbe, 2021, 29(4): 607-619.e8