Education

B.S. Shandong University, Biotechnology, 2019;
Ph.D. Institute of Biophysics, Chinese Academy of Science, Cell biology, 2015;

Professional Experience

2016-2021, University of North Carolina at Chapel hill,Postdoctoral Fellow
2021-2022, University of North Carolina at Chapel hill,Research Assistant Professor

2022-now,School of Life Sciences, Xiamen University, Professor

Research Area

The gastrointestinal tract harbors a highly complex microbial community, including bacteria, fungus, virus, etc., which is referred to as intestinal microbiota. The entire genome sequence of a microbial community is referred to as the microbiome. With increasing evidence suggesting that the imbalance of gut microbiota plays a significant role in the pathogenesis of multiple diseases, interactions between host immune system and gut microbiota are now attracting emerging interest. Our lab investigates the function of gut microbiota in multiple diseases, such as radiation-induced damage, colitis, viral infection and cancer, etc.. Meanwhile, we will work on developing new diagnostic methods and treatments based on microbiota and related metabolites.

Selected Publications (*Corresponding author, #co-first author)

1. Zhang MD, Guo H. Conversation between host and gut microbiota unveils a “silver bullet” therapeutic option for chemotherapy. Cell Host & Microbe, 2024, Sep 11; Volume 32, Issue 9, 1455 – 1457.
2. Zhang X, Yin Z, Zhang J, Guo H, Li J, Nie X, Wang S, Zhang L. Enterovirus 71 Activates Plasmacytoid Dendritic Cell-Dependent PSGL-1 Binding Independent of Productive Infection. Journal of Immunology. 2024 Jun 1;212(11):1782-1790. doi: 10.4049/jimmunol.2300407. PMID: 38629901; PMCID: PMC11102030.
3. Brickey WJ^#, Caudell DL^#, Macintyre AN, Olson JD, Dai Y, Li S, Dugan GO, Bourland JD, O'Donnell LM, Tooze JA, Huang G, Yang S, Guo H, French MN, Schorzman AN, Zamboni WC, Sempowski GD, Li Z, Owzar K, Chao NJ, Cline JM^*, Ting JPY^*. The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2122178120. doi: 10.1073/pnas.2122178120. Epub 2023 Dec 5. PMID: 38051771; PMCID: PMC10723152. ^#*Contributed equally.
4. Wang H^#, Liu J^#, Wu Z, Zhao Y, Cao M, Shi B, Chen B, Chen N, Guo H, Li N, Chen J, Xu R. Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis. Gut Pathogens. 2023 Jul 6;15(1):33. doi: 10.1186/s13099-023-00553-0. PMID: 37415173; PMCID: PMC10324172. ^#*Contributed equally.
5. Ravichandra Vemuri, Alistaire Ruggiero, Jordyn M Whitfield, Greg O Dugan, J Mark Cline, Masha R Block, Hao Guo, Kylie Kavanagh. Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates. Am J Physiol Heart Circ Physiol. 2022 Mar 1;322(3):H474-H485.
6. Hao Guo, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W Tam, W. June Brickey, Liang Chen, Nathan D. Montgomery, Xin Li, Lauren M. Bohannon, Anthony D. Sung, Nelson J. Chao, Jonathan U. Peled, Antonio L.C. Gomes, Marcel R.M. van den Brink, Matthew J. French, Andrew N. Macintyre, Gregory D. Sempowski, Xianming Tan, R. Balfour Sartor, Kun Lu and Jenny P.Y. Ting. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 30 Oct 2020 :Vol. 370, Issue 6516, eaay9097.
7. Wei-Chun Chou^#, Zengli Guo^#, Hao Guo, Liang Chen, Ge Zhang, Ling Xie, Xianming Tan, Sara A. Gibson, Elena Rampanelli, Yan Wang, Stephanie A. Montgomery, W. June Brickey, Meng Deng, Leslie Freeman, Song Zhang, Maureen A Su, Xian Chen, Yisong Y. Wan^*, Jenny P.-Y. Ting^*. AIM2 in regulatory T (Treg) cells restrains autoimmune diseases. Nature. 2021; 591 (7849), 300-305. ^#*Contributed equally.
8. Hao Guo^#, Sara A. Gibson^#, Jenny P.-Y. Ting. Gut Microbiota, NLR Proteins and Intestinal Homeostasis. Journal of Experimental Medicine. 2020 Oct 5;217(10): e20181832. ^#Contributed equally.
9. Agnieszka D. Truax^#, Liang Chen^#, Jason W. Tam, Ning Cheng, Hao Guo, A. Alicia Koblansky, Wei-Chun Chou, Justin E. Wilson, W. June Brickey, Alex Petrucelli, Rongrong Liu, Daniel E. Cooper, Mark J. Koenigsknecht, Vincent B. Young, Mihai G. Netea, Rinke Stienstra, R. Balfour Sartor, Stephanie A. Montgomery, Rosalind A. Coleman, and Jenny P.-Y. Ting. The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host & Microbe. 2018; 24, 364–378. ^#Contributed equally.
10. Cathryn J. Kurkjian^#, Hao Guo^#, Nathan D. Montgomery, Ning Cheng, Hong Yuan, Joseph R. Merrill, Gregory D. Sempowski, W. June Brickey, and Jenny P.-Y. Ting. The Toll–Like Receptor 2 agonist, FSL-1 lipopeptide, therapeutically mitigates acute radiation syndrome. Scientific Reports. 2017; 7: 17355. ^#Contributed equally.
11. Xuyuan Zhang, Pan Yang, Nan Wang, Jialong Zhang, Jingyun Li, Hao Guo, Xiangyun Yin, Zihe Rao, Xiangxi Wang, and Liguo Zhang. The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection. Protein Cell. 2017;8(8):590-600. doi:10.1007/s13238-017-0405-7.
12. Xiangyun Yin, Haisheng Yu, Xiaoyang Jin, Jingyun Li, Hao Guo, Quanxing Shi, Zhao Yin, Yong Xu, Xuefei Wang, Rong Liu, Shouli Wang, and Liguo Zhang. Human Blood CD1c+ Dendritic Cells Encompass CD5 high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions. The Journal of Immunology, 2017 Feb 15;198(4):1553-1564. doi: 10.4049/jimmunol.1600193.
13. Hao Guo, Jialong Zhang, Xuyuan Zhang, Yanbing Wang, Haisheng Yu, Xiangyun Yin, Jingyun Li, Peishuang Du, Joel Plumas, Laurence Chaperot, Jianzhu Chen, Lishan Su, Yongjun Liu, and Liguo Zhang. SCARB2/LIMP-2 Regulates Interferon Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7. The Journal of Immunology, 2015; 194(10):4737-49.