Education

B.S. 1999, Xiamen University, Biology
Ph.D. 2005, Xiamen University, Zoology

Professional Experience

2006 to Present,Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University

Research Area

Our research is focused on three major areas: molecular virology, molecular vaccinology and animal model. Current interests include: discovery of broad spectrum neutralizing epitopes and pathogenesis of key infectious viruses, research and development of novel antiviral vaccine and oncolytic virus drug, and development of cellular and animal models.

Selected Publications (*Corresponding author, #co-first author)

1.Xu L^#, Zheng Q^#, Zhu R^#, Yin Z^#, Yu H^#, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH^*, Li S^*, Cheng T^*, Xia N^*. Cryo-EM Structures Reveal the Molecular Basis of Receptor-Initiated Coxsackievirus Uncoating. Cell Host & Microbe. 2021, 29(3):448-462.
2.Wang W^#, Pan D^#, Fu W^#, Ye X^#, Han J, Yang L, Jia J, Liu J, Zhu R, Zhang Y, Liu C, Ye J, Selariu A, Que Y, Zhao Q, Wu T, Li Y, Zhang J^*, Cheng T^*, Zhu H^*, Xia N^*. Development of a skin- and neuro-attenuated live vaccine for varicella. Nature Communications. 2022, 13(1):824.
3.Zhang Y^#, Wei M^#, Wu Y^#, Wang J^#, Hong Y^#, Huang Y^#, Yuan L, Ma J, Kai Wang 1, Wang S, Shi Y, Wang Z, Guo H, Xiao J, Yang C, Ye J, Chen J, Liu Y, Fu B, Lan M, Gong P, Huang Z, Su Y, Chen Y, Zhang T, Zhang J, Zhu H, Yu H^*, Yuan Q^*, Cheng T^*, Guan Y^*, Xia N^*.Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants. Cell Reports. 2022, 38(12):110558.
4.Wang W^#, Zheng Q^#, Pan D^#, Yu H^#, Fu W, Liu J, He M, Zhu R, Cai Y, Huang Y, Zha Z, Chen Z, Ye X, Han J, Que Y, Wu T, Zhang J, Li S^*, Zhu H^*, Zhou ZH^*, Cheng T^*, Xia N^*. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nature Microbiology. 2020, 5(12):1542-1552.
5.He M^#, Xu L^#, Zheng Q^#, Zhu R^#, Yin Z^#, Zha Z, Lin Y, Yang L, Huang Y, Ye X, Li S, Hou W, Wu Y, Han J, Liu D, Li Z, Chen Z, Yu H, Que Y, Wang Y, Yan X, Zhang J, Gu Y, Zhou ZH^*, Cheng T^*, Li S^*, Xia N^*. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host & Microbe. 2020, 27(2):249-261.
6.Zheng Q^#, Zhu R^#, Xu L^#, He M^#, Yan X^#, Liu D, Yin Z, Wu Y, Li Y, Yang L, Hou W, Li S, Li Z, Chen Z, Li Z, Yu H, Gu Y, Zhang J, Baker TS, Zhou ZH, Graham BS^*, Cheng T^*, Li S^*, Xia N^*. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nature Microbiology. 2019, 4(1):124-133.
7.Yuan L^#, Zhang Y^#, Liu X^#, Chen Y, Zhang L, Cao J, Li X, Wang M, Wu K, Zhang J, Liu G, Tang Q, Yuan Q^*, Cheng T^*, Xia N. Agonist c-Met Monoclonal Antibody Augments the Proliferation of hiPSC-derived Hepatocyte-Like Cells and Improves Cell Transplantation Therapy for Liver Failure in Mice. Theranostics. 2019, 9(7):2115-2128.
8.Zhu R^#, Xu L^#, Zheng Q^#, Cui Y^#, Li S^#, He M, Yin Z, Liu D, Li S, Li Z, Chen Z, Yu H, Que Y, Liu C, Kong Z, Zhang J, Baker TS, Yan X^*, Hong Zhou Z^*, Cheng T^*, Xia N^*.Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10. Science Advances. 2018, 4(9):eaat7459.
9.Yuan L^#, Jiang J^#, Liu X^#, Zhang Y, Zhang L, Xin J, Wu K, Li X, Cao J, Guo X, Shi D, Li J, Jiang L, Sun S, Wang T, Hou W, Zhang T, Zhu H, Zhang J, Yuan Q, Cheng T^*, Li J^*, Xia N^*. HBV infection-induced liver cirrhosis development in dual-humanized mice with human bone mesenchymal stem cell transplantation. Gut. 2019, 68(11):2044-2056.
10.Xu L, Zheng Q, Li S, He M, Wu Y, Li Y, Zhu R, Yu H, Hong Q, Jiang J, Li Z, Li S, Zhao H, Yang L, Hou W, Wang W, Ye X, Zhang J, Baker TS, Cheng T^*, Zhou ZH, Yan X^*, Xia N^*. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nature Communications. 2017, 8(1):505.  
11.Yuan L, Liu X, Zhang L, Zhang Y, Chen Y, Li X, Wu K, Cao J, Hou W, Que Y, Zhang J, Zhu H, Yuan Q^*, Tang Q^*, Cheng T^*, Xia N. Optimized HepaRG is a suitable cell source to generate human liver chimeric mouse model for chronic hepatitis B virus infection. Emerg Microbes Infect. 2018, 7(1):144.
12.Yuan L, Liu X, Zhang L, Li X, Zhang Y, Wu K, Cao J, Hou W, Zhang J, Zhu H, Yuan Q^*, Tang Q^*, Cheng T^*, Xia N. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cell for the Chronic Hepatitis B Virus Infection. Frontiers in Microbiology. 2018, 9:908.
13.Li S, Armstrong N, Zhao H, Hou W, Liu J, Chen C, Wan J, Wang W, Zhong C, Liu C, Zhu H, Xia N, Cheng T^*, Tang Q^*. Zika Virus Fatally Infects Wild Type Neonatal Mice and Replicates in Central Nervous System. Viruses. 2018, 10(1):pii:E49.
14.Wang W, Fu W, Pan D, Cai L, Ye J, Liu J, Liu C, Que Y, Xia N, Zhu H^*, Cheng T^*. Varicella-zoster virus ORF7 interacts with ORF53 and plays a role in its trans-Golgi network localization. Virologica Sinica. 2017, 32(5):387-95.
15.Li S, Zhao H, Yang L, Hou W, Xu L, Wu Y, Wang W, Chen C, Wan J, Ye X, Liang Z, Mao Q^*, Cheng T^*, Xia N. A neonatal mouse model of coxsackievirus A10 infection for anti-viral evaluation. Antiviral Research. 2017, 144:247-55.
16.Wu Y, Zhu R, Xu L, Li Y, Li S, Yu H, Li S, Zhu H, Cheng T^*, Xia N. A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against Enterovirus 71 and Varicella-Zoster Virus. Vaccine. 2017, 35(20):2728-35.
17.Wang W, Wang X, Yang L, Fu W, Pan D, Liu J, Ye J, Zhao Q, Zhu H, Cheng T^*, Xia N. Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo. Virology. 2016, 491:96-105.
18.Zhu R, Liu J, Chen C, Ye X, Xu L, Wang W, Zhao Q, Zhu H, Cheng T^*, Xia N. A highly conserved epitope-vaccine candidate against varicella-zoster virus induces neutralizing antibodies in mice. Vaccine. 2016. 34:1589-96.
19.Liu J, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, Zhu H, Cheng T^*, Xia N. A monoclonal antibody-based VZV Glycoprotein E Quantitative Assay and Its Application on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol, 2015, 99(11):4845-53
20.Xu L, He D, Li Z, Zheng J, Yang L, Yu M, Yu H, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, Cheng T^*, Xia N. Protection against lethal Enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics. 2014, 4(5):498-513.