Education

B.S. 2010, Xiamen University, Biological Sciences;
Ph.D. 2015, Xiamen University, Biochemistry and Molecular Biology;

Professional Experience

Post-doctor, College of Chemistry and Chemical Engineering, Xiamen University, 2015-2017;
Post-doctor, School of Life Sciences, Xiamen University, 2017-2019;
Professor, School of Life Sciences, Xiamen University, 2019 to Present.

Research Area

The main interest of our lab is the understanding of metabolic regulation and cell fate determination of tumor cells, focusing on the process of sensing and adaptation of tumor cells to metabolic stress, and analyzing the role of nuclear receptor and other key node proteins in signal transduction and microenvironment remodeling.

Selected Publications (*Corresponding author, #co-first author)

1.Ma T, Tian X, Zhang BD, Li MQ, Wang Y, Yang CY, Wu JF, Wei XY, Qu Q, Yu YX, Long ST, Feng JW, Li C, Zhang, CX, Xie CC, Wu YU, Xu ZN, Chen JJ, Yu Y, Huang X, He Y, Yao LM, Zhang L, Zhu, MX, Wang W, Wang ZC, Zhang ML, Bao YQ, Jia WP, Lin SY, Ye ZY, Piao HL, Deng XM^*, Zhang CS^*, Lin SC^*. Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Nature, 603(7899)(2022), 159-165.
2.Zhang CS, Hardie DG^*, Lin SC^*. Glucose Starvation Blocks Translation at Multiple Levels. Cell Metabolism 31, 217-218, 2020.
3.Li MQ^#, Zhang CS^#, Zong Y^#, Feng JW, et al., Lin SC^*. Transient Receptor Potential V channels are essential for Glucose Sensing by Aldolase and AMPK. Cell Metabolism 30, 508–524, 2019. (IF=18.164)
4.Zong Y^#, Zhang CS^#, Li MQ, Wang W, Wang ZH, Simon A. H, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang CX, Ye ZY, Lin SY, Piao HL, D. G Hardie, Lin SC^* Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research, 29:460–473, 2019
5.Cai WF, Zhang C1, Wu YQ, Zhuang G, Ye Z, Zhang CS^*, and, Lin SC^*. Glutaminase GLS1 senses glutamine in a nonenzymatic manner triggering mitochondrial fusion. Cell Research 28, 865–867, 2018 (IF: 17.85)
6.Zhang CS^#, Hawley SA^#, Zong Y^#, Li MQ^#, Wang ZC,  Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG^*, Lin SC^*. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature 548, 112-116, 2017 (IF=43.037)
7.Zhang CS^#, Li M^#, Ma T^#, Zong Y, Cui J, Feng JW, Wu, YQ, Lin SY, and Lin SC^*. Metformin activates AMPK through the lysosomal pathway. Cell Metabolism 24, 521-2, 2016  (IF=18.164)
8.Zhang CS, and Lin SC^*. AMPK Promotes Mitophagy through Facilitating Mitochondrial Fission. Cell Metabolism 23, 399-341, 2016  (IF=18.164)
9.Zhang CS^#, Liu Q^#, Li MQ^#, Lin SY^#, Peng YY, Wu D, Li TY, Fu Q, Jia WP, Wang XJ, Ma T, Zong Y, Cui JW, Pu CF, Lian GL, Guo GL, Ye ZY, Lin SC^*. RHOBTB3 promotes proteasomal degradation of HIF1alpha through facilitating hydroxylation and suppresses the Warburg effect. Cell Res. 25, 1025-42, 2015  (IF=15.606)
10.Zhang CS^#, Jiang B^#,Li MQ^#, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC^*. The Lysosomal v-ATPase-Ragulator Complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism 20, 526-40, 2014  (IF=18.164)
11.Zhang YL^#, Guo HL^#, Zhang CS^#, Lin SY, Li P, WU JW, and Lin SC^*. AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism 18, 546–555, 2013 (IF=18.164)