Education

2007-2011,  B.S. Biotechnology, Huazhong University of Science and Technology

2011-2016,  Ph.D. Neuroscience, the University of Tennessee Health Science Center

Professional Experience

2017-2019,  Postdoc. St. Jude Children’s Research Hospital  

2020,  Professor, School of Life Sciences, Xiamen University

Research Area

To elucidate the cellular and molecular mechanisms of RNA metabolism and how the dysfunction of RNA metabolism contributes to degenerative diseases, such as ALS/FTD/IBM;To uncover the role of autophagy in the pathogenesis of neurodegeneration.

Selected Publications(* Corresponding author)：

1.Wang, B., Pareek, G., and Kundu, M. ^# (2024). ULK/Atg1: phasing in and out of autophagy. Trends Biochem Sci, 4(1), https://doi.org/10.1016/j.tibs.2024.03.004
2.Liang, P.^*, Wu, Y.^*, Zheng, S.^*, Zhang, J., Yang, S., Wang, J., Ma, S., Zhang, M., Gu, Z., Liu, Q., Jiang, W., Xing, Q., and Wang, B.^# (2024). Paxillin Phase Separation Promotes Focal Adhesion Assembly and Integrin Signaling. J Cell Biol, 223(4): e202209027
3.Liang, P., and Wang, B.^# (2024). An autophagy-independent role of ULK1/ULK2 in mechanotransduction and breast cancer cell migration. Autophagy, 1-2
4.Zhang, M.^*, Gu, Z.^*, Ma, S., Yang, S., Guo, J., Shu, L., Ge, Y., Chen, Z., and Wang, B. ^# (2024). SRRM2 Phase Separation Drives Assembly of Nuclear Speckle Subcompartments. Cell Reports, 43(3)
5.Liang, P.^*, Zhang, J.^*, Wu, W.^*, Zheng, S.^*, Xu, Z., Yang, S., Wang, J., Ma, S., Xiao, L., Hu, T., Jiang, W., Huang, C., Xing, Q., Kundu, M. ^#, and Wang, B. ^# (2023). An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration. EMBO reports, 2023, 24(11): e56850
6.Liang, P. ^*, Zhang, J. ^*, and Wang, B. ^# (2023). Emerging Roles of Ubiquitination in Biomolecular Condensates. Cells 12, 2329-2342
7.Li, D., Vogel, P., Li, XJ., Wang, B.^# & Kundu, M.^# (2021). ATG14 and RB1CC1 play essential roles in maintaining muscle homeostasis. Autophagy, 1-10.
8.Wang, B., Stanford, K. & Kundu, M. (2020). ER-to-Golgi trafficking and its implication in neurological diseases. Cells 9, 408-418.
9.Wang, B., Maxwell, B., Joo, J.H., Gwon, Y., Messing, J., Mishra, A., Shaw, T., Ward, A., Quan, H., Sakurada, S.M., et al. (2019). ULK1/2 regulate stress granule disassembly through phosphorylation and activation of VCP. Mol Cell 74, 1-16. (Cover story)
^*Highlighted in Williams ER. Turning off cellular stress. Sci Signal 12:eaax9738, 2019.
10.Wang, B., Joo, JH., Mount, R., Teubner, BJW., Krenzer, A., Ward, AL., Ichhaporia, VP., Elizabeth AJ., Khoriaty, R., Peters ST., et al. (2018). The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest 128, 3319–3332.
11.Wang, B., Iyengar, R., Li-Harms, X., Joo, J.H., Wright, C., Lavado, A., Yang, M., Guan, JL., Green, DR., Cao, X., and Kundu, M. (2017). The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy 3, 1-16. (Cover story)
12.Wang, B. & Kundu, M. (2017). Canonical and noncanonical functions of ULK/Atg1. Curr. Opin. Cell Biol. 45, 47-54.
13.Joo, J.H.^*, Wang, B.^*, Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, T.I., Lindsten, T., et al. (2016). The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell 62, 491-506. ^*authors contributed equally. (Cover story)
^*Highlighted in Zhao YG and Zhang H. The Incredible ULKs: Autophagy and Beyond. Mol Cell 63:475-476, 2016.
^*Highlighted in Strzyz P. The second job of ULKs. Nat Rev Mol Cell Biol 17:396–397, 2016.
14.Kim, N.C., Tresse, E., Kolaitis, R.M., Molliex, A., Thomas, R.E., Alami, N.H., Wang, B., Joshi, A., Smith, R.B., Ritson, G.P., et al. (2013). VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 78, 65-80.
15.Xiao, L., Wang, B., Yang, G., and Gauthier, G. (2012). Poly(Lactic Acid)-Based Biomaterials: Synthesis, Modification and Applications, Biomedical Science, Engineering and Technology, Dhanjoo N. Ghista (Ed.) , ISBN: 978-953-307-471-9.