Education

1999, MD M.Sc., Fourth Military MedicalUniversity;

2002, Ph.D., Fourth Military Medical University.

Professional Experience

2000 - 2001,Visiting student, Boston University School of Medicine;

2001- 2003, Visiting scholar, Massachusetts Institute of Technology;

2003 - 2007, Postdoc fellow, University of Toronto;

2007- present, Professor, School of Life Sciences, Xiamen University.

Research Area

The main interest of the lab is the understanding of the reciprocal regulation between PI3K/AKT/FoxO pathway and epigenetic modulation mechanisms. We are particularly interested in investigating how these crosstalks controlling chemoresistance and cancer metastasis. In addition, we are also interested in characterizing key molecules and signaling networks regulating cell differentiation, apoptosis and autophagy.

Selected Publications

1.Xiao Lu, Lichao Peng, Jiancheng Ding, Yuanpei Li, Qing Li, Mengchen Rao, Tong Shu, Xiaoniu He, Chen Liu, Jing Ye^*, Wen Liu^*, Han You^*. A deregulated m6A writer complex axis driven by BRD4 confers an epitranscriptomic vulnerability in combined DNA repair-targeted therapy. PNAS. 2023. DOI: 10.1073/pnas.2304534120
2.Yuanpei Li, Xiaoniu He, Xiao Lu, Zhicheng Gong, Qing Li, Lei Zhang, Ronghui Yang, Chengyi Wu, Jialiang Huang, Jiancheng Ding, Yaohui He, Wen Liu, Ceshi Chen, Bin Cao, Dawang Zhou,YuFeng Shi, Juxiang Chen, Chuangui Wang, Shengping Zhang, Jian Zhang, Jing Ye, Han You^*. METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions. Nature Communications. 2022, Oct26;13(1):6350
3.Gong, Z., Li AC., Ding JC., Li, Q., Zhang L., Li YP., Meng Z., Chen F., Huang JL., Zhou DW., Hu RG., Ye, J., Liu W. and You, H^*. OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis and Breast Cancer Metastasis. Adv Sci (Weinh) . 2021. Aug;8(15):e2004504.
4.Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H^*. Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis. J Clin Invest. 2017, 127(6):2159-2175
5.Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H^*. FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling. Hepatology 2016, 63(6):1914-1927
6.Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H^*. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy 2015, 11(9):1623-1635.
7.Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H^*. Chaperone-like protein p32 regulates ULK1 stability and autophagy. Cell Death Differ.,2015, 22(11):1812-1823.
8.Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H^*.TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. PNAS . , 2012, 109(51), pp 20937-20942.
9.Zhang YR, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW^*, You H^*.Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1. PNAS. ,2012. 109(15), pp 5717-5722
10.Mei Y, Wang Z，Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H^*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO 1/3/4 through the receptor tyrosine kinase PDGFRA. PNAS. ,2012. 109(13), pp 4898-4903
11.Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H^*, Kwiatkowski D, Zhang H^*. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. PNAS. ,2011, 108(10):4129-34.
12.Mei Y, Zhang YR, Yamamoto K, Xie W, Mak TW^*, You H^*. FoxO3a -dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation. PNAS., 2009, 106(13):5153-8.