Education

B.S. 2000, Xiamen University, Biotechnology;

M.S. 2003, Xiamen University, Biochemistry and Molecular Biology;

Ph.D. 2018, Texas A&M University, Biomedicine;

Professional Experience

2009-2015, Postdoctoral Fellow at School of Medicine, Case Western Reserve University

2015-2016, Research Scientist at School of Medicine, Case Western Reserve University

2016-present, Principal Investigator, Professor, School of Life Sciences, Xiamen University

Research Area

1. Cancer Metabolism and Ferroptosis;

2. Epigenetics and Targeting Drug Screening System Development;

3. Multi-Omics for Cancer Biomarker Discovery and Early Cancer Diagnosis;

4. AI-aided Drug Design and Biomaterial Development;

5. Synthesis Biology and IVD Enzyme Development.

Selected Publications (*Corresponding author, #co-first author)

1. Zheng H, Chen H, Cai Y, Shen M, Li X, Han Y, Deng X, Cao H, Liu j, Liu B, LI G, Wang X, Chen H, Hou J, Lin S-H, Zong L, Zhang Y*. Hydrogen sulfide-mediated persulfidation regulates homocysteine metabolism and enhances ferroptosis in non-small-cell lung cancer. Molecular Cell, 2024
2. Liu J, Lu X, Zeng S, Fu R, Wang X, Luo L, Huang T, Deng X, Zheng H, Ma S, Ning D, Zong L, Lin SH, Zhang Y*. ATF3-CBS signaling axis coordinates ferroptosis and tumorigenesis in colorectal cancer. Redox Biology, 2024
3. Li H, Yu K, Hu H, Zhang X, Zeng S, Li J, Dong X, Deng X, Zhang J, Zhang Y*. METTL17 coordinates ferroptosis and tumorigenesis by regulating mitochondrial translation in colorectal cancer. Redox Biology, 2024
4. Li H, Yu K, Zhang X, Li J, Hu h, Deng X, Zeng S, Dong X, Zhao J, Zhang Y*. YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response. Genes & Diseases, 2024
5. Li W, Chen M, Wang T, Feng X, Jiang X, Dong X, Zhang H, Tang X, Tian R, Zhang Y*, Li Z*. Characterization and humanization of VNARs targeting human serum albumin from the whitespotted bamboo shark (Chiloscyllium plagiosum), Int J Biol Macromol. 2024
6. Ma S, Xiao G, Deng X, Tong M, Huang J, Li Q, Zhang Y. CovidShiny: An Integrated Web Tool for SARS-CoV-2 Mutation Profiling and Molecular Diagnosis Assay Evaluation In Silico. Viruses, 2023
7. Guo P, Chen Q, Peng K, Xie J, Liu J, Ren W, Tong Z, Li M, Zhang Y*, Yu C*, Mo P*, Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. Oncogene, 2022
8. Yan T, Xu Y, Zheng R, Zeng X, Chen Z, Lin S, Xia Z, Liao Y, Zhang Y*, Li Q*. Accessible and Adaptable Multiplexed Real-Time PCR Approaches to Identify SARS-CoV-2 Variants of Concern. Microbiol Spectral.2022.
9. Ma S; Zhang Y*. Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq. Molecular Biomedicine., 2020, 1(1)
10. Antczak MI*, Zhang Y#, Wang C, Doran J, Naidoo J, Voruganti S, et al. Inhibitors of 15- Prostaglandin Dehydrogenase To Potentiate Tissue Repair. Journal of Medicinal Chemistry .2017;60: 3979-4001
11. Y. Zhang#, A, Desai# S. Yang# K. Bae#, M. Antczak#, S. Fink, S#. Tiwari#, et al. S.D. Markowitz, Inhibition of the Prostaglandin Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration. Science.. Jun 12;348(6240), 2015
12. D. Zhou*, Y. Zhang#, H. Wu, E. Barry, Y. Yi, E. Lawrence, D. Dawson J.E. Willis, S.D. Markowitz, F.D. Camargo and J. Avruch. The Mst1 and Mst2 kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yap overabundance. PNAS..104(46): 2011
13. Y. Zhang#, J. Zhang, Y. Lin, Y. Lan, C. Lin, J.W. Xuan, M.M. Shen, W.L. McKeehan,N.M. Greenberg, and F. Wang. Role of epithelial cell fibroblast growth factor receptor substrate 2a in prostate development, regeneration and tumorigenesis. Development.. 135(4):775-84, 200