Shaowei Li, Ph.D. Professor. Tel:+86-592-2880620 E-mail: shaowei@xmu.edu.cn

Education

B.S. Biochemistry, Xiamen University, 1998;
Ph.D. Biochemistry & Molecular Biology/Zoology, Xiamen University, 2003;

Professional Experience

Lecturer, School of Life Sciences, Xiamen University, 2003;
Associate Professor, School of Life Sciences, Xiamen University, 2006;
Professor, School of Life Sciences, Xiamen University, 2011

Research Area

• Research and development of recombinant human vaccines
• Structural basis and functional implication for underlying immune epitopes of key infectious viruses
• Structure-based rational design for vaccine immunogens

Selected Publications

1. Li T#*, Xue W#, Zhang S#, Wang H#, Lan M#, Zhang L#, Lin M#, Zhou M#, Ying D#, Zeng Y, Cui L, Yin Y, Chen H, Ma J, Liu C, Chen J, Wang C, Yu Z, Chen Y, Wu Y, Liu H, Li H, Zhang Y, Li J, Lu Z, Chen Z, Zhang Y, Yuan L, Zhou L, Zheng Q, Yu H, Zhang J, Cheng T, Chen J*, Chen Y, Guan Y, Zheng Z*, Gu Y*, Xia N*, Li S*. Nanobody-based combination vaccine using licensed protein nanoparticles protects animals against respiratory and viral infections. Nat Biomed Eng. 2026 Jul;10(7):1373-1391. (News & views: Kealy LC, Good-Jacobson KL. Non-covalent assembly of multiple epitopes onto a single nanoparticle. Nat Biomed Eng. 2026 Jul;10(7):1275-1276.
2. Su J#, Tong X#, Jiang Y#, Li Y, Yan H, Liu Y, Wang Y, Su X, Sun Z, Wang M, Xia N, Bostina M, Li S*, Pang W*, Zheng Q*, Tian K*. Structural basis and immunogenic efficacy of porcine circovirus type 3 virus-like particle. Nat Commun. 2026 Jun 16;17(1):7664.
3. Zhen X#, Li Y#, Liu Z#, Huang Y#, Wang X#, Xu S, Jiang Y, Li F, Su J, Lai Q, Li S*, Xia N*, Zheng Q*, Ouyang S*. Filament-driven activation of the Kongming antiviral system by deoxyinosine triphosphate. Mol Cell. 2026 Mar 19;86(6):1134-1147.e4.
4. Jiang Y#, Wang Z#, Xu Q#, Zhang S, Su J, Sun H, Zhang C, Zhou L, Li T, Kong Z, Yu H, Zhang J, Zheng Q*, Gu Y*, Xia N, Li S*. Structural and biochemical characterization of neutralizing antibodies targeting human papillomavirus type 45. Structure. 2026 Apr 2;34(4):588-598.e4.
5. Tang ZM#, Yang CY#, Wen GP#, Liu C#, Ying D#, Huang Y, Yu ZH, Li MY, Wang SL, Chen ZH, Liu JF, Fang MJ, Wang YB, Zhang J, Gu Y, Yu H, Li SW*, Zheng QB*, Xia NS*, Zheng ZZ*. The crucial but insufficient role of E2s domain's residues 490 and 492 in determining the host tropism of hepatitis E virus. Nat Commun. 2026 Feb 9;17(1):2528.
6. Zhang W#, Jiang Y#, Li Y#, Zhen X#, Xu S, Xia NS, Li S*, Wang X*, Zheng Q*, Ouyang S*. Filament assembly induced by the recognition of target DNA activates the prokaryotic Argonaute SPARDA system. Nat Commun. 2026 Jan 6;17(1):115.
7. Zhou L#*, Yu Z#, Lin S#, Jiang Y#, Gao J, Ma Y, Jiang W, Liang S, Chen Y, Zhang Y, Lin Y, Liang M, Dai J, Zhang L, Xiao Y, Li T, Kong Z, Liu Q, He S, Wu Y, Yuan Q, Liu F, Zhang J, Zheng Q*, Yu H*, Gu Y*, Li S*, Xia N*. Public antibody clonotypes and deep learning identify SARS-CoV-2 and HIV broadly neutralizing antibodies in immune repertoires. Cell Rep. 2026 Jul 28;45(7):117582.
8. Wang G#, Li Y#, Wu C#, Chen T#, Gui M#, Zeng Y#, Sun H#, Chen K#, Xi X, Yang Y, Jiang Y, Jiang Y, Liu L, Yang C, Xin J, Liu C, Li Y, Huo N, Huang Y, Lin L, Yu H, Huang C, Yuan Q, Li S*, Tian K*, Zheng Q*, Xia N*, Chen Y*. A broadly neutralizing antibody confers cross-genus protection against alphaherpesviruses by inhibiting gB-mediated membrane fusion. Nat Commun. 2025 Dec 16;16(1):11144.
9. Huang Y#, Song F#, Zeng Y#, Sun H#, Sheng R#, Wang X, Liu L, Luo G, Jiang Y, Chen Y, Zhang M, Zhang S, Gu Y, Yu H*, Li S*, Li T*, Zheng Q*, Ge S*, Zhang J, Xia N*. A single residue switch mediates the broad neutralization of Rotaviruses. Nat Commun. 2025 Jan 20;16(1):838.
10. Zhang H#, Li Y#, Li L, Chen L, Zhu C, Sun L, Dong P, Jing D, Yang J, Fu L, Xiao F, Xia N, Li S*, Zheng Q*, Wu Y*. Structural insights into activation mechanisms on NADase of the bacterial DSR2 anti-phage defense system. Sci Adv. 2024 Aug 2;10(31):eadn5691.
11. Han F, Guo XY, Jiang MX, Xia NS, Gu Y*, Li SW*. Structural biology of the human papillomavirus. Structure. 2024 Nov 7;32(11):1877-1892.
12. Zheng M#, Zhou L#, Huang Y#, Zhang X, Yu Z, Yang C, Chen Y, Ying D, Wang H, Chen Z, Liu C, Tang Z, Wang S, Wang K, Yang K, Lin Y, Li T, Zheng Q, Zheng Z, Zhang J, Yu H*, Li S*, Gu Y*, Xia N*. Structural basis for the synergetic neutralization of hepatitis E virus by antibody-antibody interaction. Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2408585121.
13. Zhu R#, Wu Y#, Huang Y#, Jiang Y#, Jiang Y#, Zhang D#, Sun H#, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W*, Li S*, Zheng Q*, Xu L*, Xia N*, Cheng T*. Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2. Nat Microbiol. 2024 Nov;9(11):2939-2953.
14. Huang Y*, Sun H*, Wei S*, Cai L, Liu L, Jiang Y, Xin J, Chen Z, Que Y, Kong Z, Li T, Yu H, Zhang J, Gu Y, Zheng Q*, Li S*, Zhang R*, Xia N*. Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun. 2023 Jun 17;14(1):3609.
15. Zheng Q#, Zhu R#, Yin Z#, Xu L#, Sun H#, Yu H#, Wu Y, Jiang Y, Huang Q, Huang Y, Zhang D, Liu L, Yang H, He M, Zhou Z, Jiang Y, Chen Z, Zhao H, Que Y, Kong Z, Zhou L, Li T, Zhang J, Luo W, Gu Y*, Cheng T*, Li S*, Xia N*. Structural basis for the synergistic neutralization of coxsackievirus B1 by a triple-antibody cocktail. Cell Host Microbe. 2022 Sep 14;30(9):1279-1294.e6.
16. Li T#, Chen J#, Zheng Q#, Xue W#, Zhang L#, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y*, Chen Y*, Li S*, Xia N*. Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun. 2022 Sep 2;13(1):5182.
17. Xiong H#, Sun H#, Wang S#, Yuan L#, Liu L#, Zhu Y#, Zhang J#, Huang Y, Qi R, Jiang Y, Ma J, Zhou M, Ma Y, Fu R, Yan S, Yue M, Wu Y, Wei M, Wang Y, Li T, Wang Y, Zheng Z, Yu H, Cheng T, Li S*, Yuan Q*, Zhang J*, Guan Y*, Zheng Q*, Zhang T*, Xia N*. The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2204256119
18. Wang S#, Sun H#, Zhang Y#, Yuan L#, Wang Y#, Zhang T#, Wang S, Zhang J, Yu H, Xiong H, Tang Z, Liu L, Huang Y, Chen X, Li T, Ying D, Liu C, Chen Z, Yuan Q, Zhang J*, Cheng T*, Li S*, Guan Y*, Zheng Q*, Zheng Z*, Xia N*. Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron. Cell Rep. 2022 May 24;39(8):110862.
19. Wang G#, Zha Z#, Huang P#, Sun H#, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q*, Chen Y*, Li S*, Xia N*. Structures of pseudorabies virus capsids. Nat Commun. 2022 Mar 22;13(1):1533.
20. T Li#, W Xue#, Q Zheng#, S Song#, C Yang#, H Xiong#, S Zhang, M Hong, Y Zhang, H Yu, Y Zhang, H Sun, Y Huang, T Deng, X Chi, J Li, S Wang, L Zhou, T Chen, Y Wang, T Cheng, T Zhang, Q Yuan, Q Zhao, J Zhang, J. S. McLellan, Z Zhou*, Z Zhang*, S Li*, Y Gu*, N Xia*. Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun, 2021, 12(1): 5652-5664.
21. L Xu#, Q Zheng#, R Zhu#, Z Yin#, H Yu#, Y Lin, Y Wu, M He, Y Huang, Y Jiang, H Sun, Z Zha, H Yang, Q Huang, D Zhang, Z Chen, X Ye, J Han, L Yang, C Liu, Y Que, M Fang, Y Gu, J Zhang, W Luo, Z Zhou*, S Li*, T Cheng*, N Xia*. Cryo-EM Structures Reveal Basis of Receptor-Initiated Coxsackievirus Uncoating with Implications for Therapeutic Antibody Development. Cell Host Microbe, 2021, S1931-3128(21)00001-9.
22. W Wang#, Q Zheng#, D Pan#, H Yu#, W Fu, J Liu, M He, R Zhu, Y Cai, Y Huang, Z Zha, Z Chen, X Ye, J Han, Y Que, T Wu, J Zhang, S Li*, H Zhu*,Z Zhou*,T Cheng*and N Xia*. Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids. Nat Microbiol, 2020,5(12) :1542-1552.
23. M He#, L Xu#, Q Zheng#, R Zhu#, Z Yin, Z Zha, Y Lin, L Yang, Y Huang, X Ye, S Li, W Hou, Y Wu, J Han, D Liu, Z Li, Z Chen, H Yu, Y Que, Y Wang, X Yan, J Zhang, Y Gu, Z Zhou*, T Cheng*, S Li*, N Xia*. Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 2020, 27(2): 249-261.
24. D Wang#, X Liu#, M Wei#, C Qian, S Song, J Chen, Z Wang, Q Xu, Y Yang, M He, X Chi, S Huang, T Li, Z Kong, Q Zheng, H Yu, Y Wang, Q Zhao, J Zhang, N Xia*, Y Gu*& S Li*. Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles. Nat Commun, 2020, 11(1):2841.
25. Q Zheng#, R Zhu#, L Xu#, M He#, X Yan, D Liu, Z Yin, Y Wu, Y Li, L Yang, W Hou, S Li, Z Li, Z Chen, Z Li, H Yu, Y Gu, J Zhang, T. S. Baker, Z Zhou, B. S. Graham*, T Cheng*, S Li*, N Xia*. Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization. Nat Microbiol, 2019, 4(1): 124-133.
26. Q Zheng#, J Jiang#, M He#, Z Zheng, H Yu, T Li, W Xue, Z Tang, D Ying, Z Li, S Song, X Liu, K Wang, Z Zhang, D Wang, Y Wang, X Yan, Q Zhao, J Zhang, Y Gu*, S Li*, N Xia*. Viral neutralization by antibody-imposed physical disruption. Proc Natl Acad Sci U S A, 2019, 116(52): 26933-26940.
27. Z Li#, S Song#, M He#, D Wang, J Shi, X Liu, Y Li, X Chi, S Wei, Y Yang, Z Wang, J Li, H Qian, H Yu, Q Zheng, X Yan, Q Zhao, J Zhang, Y Gu*, S Li*, N Xia*. Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 2018, 9(1): 0-5360.
28. L Xu#, Q Zheng#, S Li#, M He#, Y Wu, Y Li, R Zhu, H Yu, Q Hong, J Jiang, Z Li, S Li, H Zhao, L Yang, W Hou, W Wang, X Ye, J Zhang, T. S. Baker, T Cheng *, Z Zhou, X Yan*, N Xia*. Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody. Nat Commun. 2017 Sep 11;8(1):505.
29. Z Li#, X Yan#, H Yu#, D Wang, S Song, Y Li, M He, Q Hong, Q Zheng, Q Zhao, Y Gu, J Zhang, M. E. Janssen, G Cardone, N. H. Olson, T. S. Baker*, Li S*, Xia N. The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction. Structure. 2016 Jun 7;24(6):874-85.
30. X Tang, C Yang, Y Gu, C Song, X Zhang, Y Wang, J Zhang, C. L. Hew, S Li*, N Xia*, J Sivaraman *. Structural basis for the neutralization and genotype specificity of hepatitis E virus. Proc Natl Acad Sci U S A. 2011, 108(25):10266-71.