报告题目：Functional interrogation of cancer cell state heterogeneity in distinct physiological contexts

报告人：    Prof. Tuomas Tammela.

报告时间：2025年4月14日上午10:30

报告地点：翔安区跃进楼学术报告厅

邀请人：    陈兰芬 教授

【报告人简介】Dr. Tammela received his M.D. and Ph.D. from the University of Helsinki, Finland, where he worked in the laboratory of Dr. Kari Alitalo, studying molecular mechanisms that control blood and lymphatic vessels growth. Dr. Tammela then moved to MIT for postdoctoral training with Dr. Tyler Jacks. During this time, he became interested in cellular heterogeneity in cancer and identified cancer-derived niches as drivers of stem-like cells in lung cancer. Dr. Tammela joined the faculty at Memorial Sloan Kettering Cancer Center in 2017 and is currently an Associate Member in the Cancer Biology & Genetics Program at the Sloan Kettering Institute. The Tammela Lab studies phenotypic heterogeneity of cancer cells within tumors using genetically engineered mouse models, single cell approaches, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated gene regulation, and advanced imaging techniques. The overarching goal of these efforts is to discover pathways that drive distinct cellular phenotypes and to develop new therapeutic concepts aimed at reducing cellular heterogeneity in tumors. In addition, emerging efforts in the Tammela laboratory focus on how aging and other changes in organismal physiology impact cancer evolution. Dr. Tammela holds scholarships from the American Cancer Society, the Josie Robertson Foundation, the Rita Allen Foundation, and the V Foundation. He is a recipient of a Mark Foundation Emerging Leader Award, an NIH-NCI R37 MERIT Award, an AACR Next Generation Transformative Research Award, and the Werner Risau Prize.