Lixin HONG

Post on: 2016-05-25Source: Hits: 549

Lixin HONG, Ph.D.

Assistant Professor.

Tel: +86-592-2180340



2001-2005, B.Sc., School of Life Science, Xiamen University, China;

2005-2008, Ph.D., School of Life Science, Xiamen University, China;

2008-2010, Ph.D., The Scripps Research Institute, La Jolla, California, USA.

Professional Experience

2010-2013, Research Associate, The Scripps Research Institute, La Jolla, California, USA;

2013-present, Assistant Professor, School of Life Science, Xiamen University, China.

Research Area

Hippo signaling pathway was firstly discovered in Drosophila, which plays an important role not only in the regulation of organ size, but also in tumor development and cancer occurrence. Currently, through the studies of molecular, biochemical, cell biology and animal models, it reveals that Hippo signaling pathway is important in the development of cancer, especially liver cancer, which provide a theoretical basis for the prevention and treatment of cancer-related diseases.

Selected Publications

1. Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L, Zhou D. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature Immunol. 2015. doi: 10.1038/ni.3268

2. Wu, H., Wei, L., Fan, F., Ji, S., Zhang, S., Geng, J., Hong, L., Fan, X., Chen, Q., Tian, J., Jiang, M., Sun, X., Jin, C., Yin, Z. Y., Liu, Q., Zhang, J., Qin, F., Lin, K. H., Yu, J. S., Deng, X., Wang, H. R., Zhao, B., Johnson, R. L., Chen, L., and Zhou, D. (2015) Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis, Nat Commun, 6, 6239.

3. Hong, L., Cai, Y., Jiang, M., Zhou, D., and Chen, L. (2015) The Hippo signaling pathway in liver regeneration and tumorigenesis, Acta Biochim Biophys Sin 47, 46-52.

4. Wang, P., Zhou, Z., Hu, A., Ponte de Albuquerque, C., Zhou, Y., Hong, L., Sierecki, E., Ajiro, M., Kruhlak, M., Harris, C., Guan, K. L., Zheng, Z. M., Newton, A. C., Sun, P., Zhou, H., and Fu, X. D. (2014) Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt, Mol Cell, 54, 378-391.

5. Tian, L., Chen, J., Chen, M., Gui, C., Zhong, C. Q., Hong, L., Xie, C., Wu, X., Yang, L., Ahmad, V., and Han, J. (2014) The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU, J Biol Chem, 289, 31856-31865.

6. Yoshizuka, N., Chen, R. M., Xu, Z., Liao, R., Hong, L., Hu, W. Y., Yu, G., Han, J., Chen, L., and Sun, P. (2012) A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis, Mol Cell Biol, 32, 606-618.

7. Kolesnichenko, M., Hong, L., Liao, R., Vogt, P. K., and Sun, P. (2012) Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence,Cell Cycle, 11, 2391-2401.

8. Kang, Y. J., Otsuka, M., van den Berg, A., Hong, L., Huang, Z., Wu, X., Zhang, D. W., Vallance, B. A., Tobias, P. S., and Han, J. (2010) Epithelial p38alpha controls immune cell recruitment in the colonic mucosa, PLoS Pathog, 6, e1000934.

9. Hong, L., Lai, M., Chen, M., Xie, C., Liao, R., Kang, Y. J., Xiao, C., Hu, W. Y., Han, J., and Sun, P. (2010) The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence,Cancer Res, 70, 8547-8557.

10. Chen, J., Xie, C., Tian, L., Hong, L., Wu, X., and Han, J. (2010) Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi, Proc Natl Acad Sci U S A, 107, 20774-20779.

11. Kwong, J., Hong, L(co-first)., Liao, R., Deng, Q., Han, J., and Sun, P. (2009) p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms, J Biol Chem, 284, 11237-11246.

12. Yang, Z., Cheng, W., Hong, L., Chen, W., Wang, Y., Lin, S., Han, J., Zhou, H., and Gu, J. (2007) Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 cells, Mol Biol Cell, 18, 4681-4689.