Lei ZHANG, Ph.D.
2006, B.Sc., Hunan Normal University;
2009, M.Sc., Hunan Normal University;
2012, PhD., Xiamen University.
2012- present, Assistant Professor, School of Life Sciences, Xiamen University.
The main interest of the lab is the understanding of stress response regulated by insulin signaling pathway. We are particularly interested in studying the role of FOXO transcription factors in response to various types of stress, including oxidative stress, DNA damage and nutrient deprivation. FOXO transcription factors have been described as longevity factors in both worms and flies. Whether it holds the same function in mammals is not clear. Moreover, several lines of evidence suggest FOXOs as tumor suppressors, but the critical downstream mediators are unknown. We will employ cellular biochemical and molecular biological approaches to address these questions. Hopefully our studies will provide insights into the molecular mechanisms in human aging and age-related diseases.
1. Zhang L, Mei Y, Fu N Y, Guan L, Xie W, Liu H H, Yu C D, Yin Z, Yu V C, and You H*. TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. Proc Natl Acad Sci USA, 109(51), 20937-20942, 2012.
2. Mei Y, Wang Z, Zhang L (co-first author), Zhang Y, Li X, Liu H, Ye J, You H*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci USA, 109(13), 4898-4903, 2012
3. Zhang Y, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak T W*, and You H*. Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1. Proc Natl Acad Sci USA, 109(15), 5717-5722, 2012.
4. Ma S, Huang W, Zhang L, Zhao S, Tong Y, Liu Z, Sun L, Chen H, and Luo C*. Germ cell-specific DNA methylation and genome diploidization in primitive vertebrates. Epigenetics, 6(12), 1471-1480. 2011