Quanwen JIN, Ph.D.
1990, B.Sc., Northeast Normal University;
1993, M.Sc., Northeast Normal University;
1999, Ph.D., University of Vienna, Austria.
1999-2002, Postdoctoral fellow sponsored by Alexander von Humboldt Research Fellowship at Henrich-Heine Duesseldorf University, Germany;
2002-2006, Postdoctoral fellow, University of Massachusetts Medical School, USA;
2006-Present, Professor, School of Life Sciences, Xiamen University.
Our research interests mainly focus on three basic questions using fission yeast Schizosaccharomyces pombe as our model organism: (1) The epigenetic mechanism of RNAi and heterochromatin formation regulated by heat-shock protein Hsp90; (2) How the fidelity of mitotic chromosome segregation is ensured by activation and silencing of spindle assembly checkpoint; (3) The molecular mechanisms coordinating nuclear division with cell division (cytokinesis). Taking advantage of the extensive technical amenability of the fission yeast, our group employs multi-disciplinary approaches, such as genetics, cell biology and molecular biology, to dissect the detailed mechanisms how the cell cycle is regulated.
1. Chen Y, Chen L, An K, Wang Y, Jin Q. A vector system for efficient and economical switching of a ura4(+) module to three commonly used antibiotic marker cassettes in Schizosaccharomyces pombe. Yeast. 32(11): 671-82, 2015.
2. Yu ZY, Zhang MT, Wang GY, Xu D, Keifenheim D, Franco A, Cansado J, Masuda H, Rhind N, Wang Y, Jin QW. Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase. J Cell Sci. 126(Pt 21): 4995-5004, 2013.
3. Cipak L, Gupta S, Rajovic I, Jin QW, Anrather D, Ammerer G, McCollum D, Gregan J. Crosstalk between casein kinase II and Ste20-related kinase Nak1. Cell Cycle. 12(6): 884-888, 2013.
4. Wang Y, Li WZ, Johnson AE, Luo ZQ, Sun XL, Feoktistova A, McDonald WH, McLeod I, Yates JR 3rd, Gould KL, McCollum D*, Jin QW*. Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein Dma1 in fission yeast. Molecular Biology of the Cell. 23:3348-3356, 2012. (*Corresponding author).
5. Li WZ, Yu ZY, Ma PF, Wang Y and Jin QW*. A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast. Molecular Biology of the Cell. 21: 4349–4360, 2010.
6. Jin QW, Ray S, Choi SH and McCollum D. The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast. Molecular Biology of the Cell. 18: 2924-2934, 2007.
7. Jin QW, Zhou M, Bimbo A, Balasubramanian MK and McCollum D. A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors. Genetics. 172: 2101-2112, 2006.
8. Jin QW and McCollum D. Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell. 2: 510-520, 2003.
9. Jin QW, Pidoux AL, Decker C, Allshire RC and Fleig U. The mal2p protein is an essential component of the fission yeast centromere. Molecular and Cellular Biology. 22: 7168-7183, 2002.
10. Davis L, Barbera M, McDonnell A, McIntyre K, Sternglanz R, Jin QW, Loidl J and Engebrecht J. The Saccharomyces cerevisiaeMUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Genetics. 157:1179-1189, 2001.
11. Jin QW, Fuchs J and Loidl J. Rabl-like chromosome arrangement is a major determinant of yeast interphase nuclear organization. Journal of Cell Science. 113:1903-1912, 2000.
12. Jin QW, Trelles-Sticken E, Scherthan H and Loidl J. Yeast nuclei display prominent centromere clustering that is reduced in nondividing cells and in meiotic prophase. Journal of Cell Biology. 141: 21-29, 1998.
13. Loidl J, Jin QW and Jantsch M. Meiotic pairing and segregation of translocation quadrivalents in yeast. Chromosoma. 107: 247-254, 1998.