Wei MO, Ph.D.
2002, B.Sc., Zhejiang University;
2008, Ph.D., Shanghai institution of biochemistryand cell biology, SIBS, CAS.
2009-2014, Postdoc fellow, UT Southwestern Medical Center, Dallas, TX, USA;
2014-Present, Professor, School of Life Sciences, Xiamen University.
One direction in our lab is to investigate the role of cancer stem cells within cancers in central and peripheralneural system. We are also interested in the epigenetic modifications during CNS and PNS development and regeneration, especially chromatin remodeling by histone methylation.
1. Mo W, Chen J, Patel A, Parada LF. (2013) CXCR4/ CXCL12 mediate autocrine cell cycle progression in NF1- associated malignant peripheral nerve sheath tumors. Cell. 152, 1077-90.
2. Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen X, Hui L, Huang R, Hu G. (2008) Nuclear beta-arrestin1 functions as a scaffold for the dephosphoryation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell. 31, 695-707.
3. Chau V, Lim SK, Mo W, Liu C, Patel AJ, McKay RM, Wei S, Posner BA, De Brabander JK, Williams NS, Parada LF, Le LQ. (2013)Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 74(2): 586-97.
4. Sanchez-Ortiz E, Cho W, Nazarenko I, Mo W, Chen J, Parada LF.(2014)NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development. Genes Dev. Nov 1; 28(21): 2407-20.