2010年，重庆大学生物工程专业，学士学位；
2013年，重庆大学生物医学工程专业，硕士学位；
2019年，美国佛罗里达州立大学生物医学专业，博士学位；
2020年，美国佛罗里达州立大学，博士后；
2020-2022年，美国贝勒医学院，博士后；
2022年，厦门大学生命科学学院，教授；
2022年，厦门大学南强青年拔尖A类人才；
2021年，国家高层次青年人才
B.S. 2010, Chongqing University, Bioengineering;
M.S. 2013, Chongqing University, Biomedical Engineering;
Ph.D. 2019, Florida State University, Biomedical Sciences;
Postdoctoral Fellow, 2020, Florida State University;
Postdoctoral Fellow, 2020-2022, Baylor College of Medicine;
Professor, 2022-Present, School of Life Sciences, Xiamen University

郑燚明教授，国家海外高层次青年人才。神经损伤疾病如脑中风和脊髓损伤是至今未解决的重大医学难题，神经细胞死亡是神经损伤和退行性疾病如老年痴呆症的主要病理学特征，及时清除坏死神经细胞对于控制神经炎症和帮助神经再生至关重要。课题组主要致力于神经系统损伤和疾病过程中的细胞吞噬和降解研究，前期工作发现神经系统除了小胶质细胞作为主要的吞噬细胞，微血管内皮细胞在神经系统疾病中具有此前未知的吞噬功能属性，在神经系统脱髓鞘疾病的发展过程中扮演重要角色，相关研究成果发表于《Nature Neuroscience》和《Nature Cell Biology》等国际权威期刊。课题组综合运用小鼠遗传学、细胞分子生物学和成像技术，研究1）血管细胞作为新型吞噬细胞在神经损伤病变中的作用和调控机制；2) 血管细胞和胶质细胞互作调控神经损伤病变的机制；3）细胞骨架重构等重要生物学过程在神经系统发育和疾病中的作用。欢迎加入我们的团队。

代表性论文(^# co-first author, ^* Corresponding author):

1. T. Zhou^#, Y. Zheng^#*, L. Sun, S.R. Badea, Y. Jin, Y. Liu, A. Rolfe, H. Sun, X. Wang, Z. Cheng, Z. Huang, N. Zhao, X. Sun, J. Li, J. Fan, C. Lee, T. L. Megraw, W. Wu, G. Wang^*, Y. Ren^*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neurosciences. 2019. 22(3):421-435. (^#co-first authors, ^*co-corresponding authors)
2. Y. Zheng^*, R.A. Buchwalter, C. Zheng, E. Wight, J.V, Chen, T. L. Megraw^*. A perinuclear microtubule organizing centre controls nuclear positioning and basement membrane secretion. Nature Cell Biology. 2020. 22(3):297-309. (^*co-corresponding authors)
3. Jiaqi Zhang^#, Jiaojiao Hu^#, Ruogu Liu^#, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng^*, Dan Li^*, Bo Wang^*. YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates. Nature Cell Biology. 2025;27(7):1148-1160 (^*co-corresponding authors)
4. Tian Zhou^*, Yue Zhong, Shoujun Yu, Ruibing Sun, Zhenwei Zhang, Xiaoyan Du, Simon Ming Yuen Lee, Zhitong Chen, Yuxiao Lai, Bing Song^*, Yiming Zheng^*, Zhen Xu^*. Microglia-specific Enrichment of Membrane-bound IgG Enhances Phagocytosis of Amyloid-beta Fibril. Neural Regeneration Research. 2024 (^* co-corresponding authors)
5. Garret M. Morton, Maria Pilar Toledo, Chunfeng Zheng, Tania Sultana, Yue J. Wang, Yiming Zheng^*, and Timothy L. Megraw^*. A distinct isoform of Msp300 (nesprin) organizes the perinuclear microtubule-organizing center in adipocytes. Mol Biol Cell. 2025 Jul 1;36(7):ar92. (^* co-corresponding authors)
6. Mengqi Ma^#, Yiming Zheng^#, Shenzhao Lu, Xueyang Pan, Kim C. Worley, Lindsay Burrage, Lauren S. Blieden, Aimee Allworth, Wei-Liang Chen, Giuseppe Merla, Barbara Mandriani, Jill A. Rosenfeld, David Li-Kroeger, Debdeep Dutta, Shinya Yamamoto, Michael F. Wangler, Undiagnosed Diseases Network, Ian Glass, Paolo Prontera, Seema R. Lalani, Hugo J. Bellen ^#. De novo variants in PLCG1 are associated with hearing impairment, ocular problems, cardiac defects, and immune dysregulation. medRxiv, eLife. 2025. (^#co-first authors)
7. Matthew J. Moulton, Kristhen Atala, Yiming Zheng, Debdeep Dutta, Dorothy K. Grange, Wen-Wen Lin, Daniel J. Wegner, Jennifer A. Wambach, Angela L. Duker, Michael B. Bober, Lisa Kratz, Carol A. Wise, Ila Oxendine, Anas Khanshour, Undiagnosed Diseases Network, F. Sessions Cole, Jonathan Rios, and Hugo J. Bellen^*. Dominant Missense Variants in SREBF2 are Associated with Dermatological, Neurological, and Skeletal Defects. Genetics in Medicine. 2024
8. Mengqi Ma, Mythily Ganapathi, Yiming Zheng, Kai-Li Tan, Oguz Kanca , Kevin E. Bove, Norma Quintanilla, Sebnem O. Sag, Sehime G. Temel, Charles A. LeDuc, Amanda J. McPartland, Elaine M. Pereira, Yufeng Shen, Jacob Hagen, Christie P. Thomas, Nhu Thao Nguyen Galván, Xueyang Pan, Shenzhao Lu, Jill A. Rosenfeld, Daniel G. Calame…Hugo J. Bellen. Homozygous missense variants in YKT6 result in loss of function and are associated with developmental delay, with or without severe infantile liver disease and risk for hepatocellular carcinoma. Genetics in Medicine. 2024
9. Mengqi Ma, Xi Zhang, Yiming Zheng, Shenzhao Lu, Xueyang Pan, Xiao Mao, Hongling Pan, Hyung-Lok Chung, Hua Wang, Hong Guo, Hugo J Bellen. The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Hum Mol Genet. 2023;32(6):984-997
10. M.L. Tillery, C.B. Hedges, Y. Zheng, R. A. Buchwalter, T. L. Megraw. Centrosomal and Non-centrosomal microtubule-organizing centers (MTOCs) in Drosophila melanogaster. (review). Cells. 2018, 7(9). pii: E121.
11. Y. Zheng^#, V. Mennella^#, S. Marks, J. Wildonger, E. Elnagdi, D. Agard, T.L. Megraw. The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes, but is not required for normal development, behavior, or DNA damage response in Drosophila. Mol Biol Cell. 2016. 27(11):1740-52. (^#co-first authors)
12. Y. Zheng, J. Qiu, J. Hu, G. Wang. Concepts and hypothesis: Integrin cytoplasmic domain-associated protein-1 (icap-1) as a potential player in cerebral cavernous malformation. J Neurol. 2013, 260(1):10-9.

荣誉、奖励及参加学术团体的情况:

优秀青年科学基金项目（海外），国家自然科学基金 2021
福建省高层次人才（B类），2021