李柳菊副教授
邮 箱：liliuju@xmu.edu.cn
职称/职务： 副教授
联系方式：
- 个人简介
- 科研领域
- 代表性成果
2016年，湖南师范大学生物科学专业，学士学位；
2021年，北京大学生物物理学专业，博士学位；
2021-2026年，北京大学，博士后；
2026年，厦门大学生命科学学院，副教授
B.S. Biological Sciences, Hunan Normal University, 2016;
Ph.D. Biophysics, Peking University, 2021;
Postdoctoral Fellow, Peking University, 2021-2026;
Associate Professor, School of Life Sciences, Xiamen University, 2026
2021年，北京大学生物物理学专业，博士学位；
2021-2026年，北京大学，博士后；
2026年，厦门大学生命科学学院，副教授
B.S. Biological Sciences, Hunan Normal University, 2016;
Ph.D. Biophysics, Peking University, 2021;
Postdoctoral Fellow, Peking University, 2021-2026;
Associate Professor, School of Life Sciences, Xiamen University, 2026
糖原是细胞内重要的葡萄糖储存形式，并以具有层级组织的颗粒结构存在。除多糖链外，糖原颗粒还富集多种糖原合成和分解相关酶及调控蛋白，构成局部代谢反应单元。课题组前期研究发现，人多能干细胞中的糖原颗粒进一步组装形成更高阶的无膜代谢区室，即糖原凝聚体。结合结构光照明超分辨成像、无标记光学衍射层析成像等技术，课题组重点解析糖原凝聚体的组装、定位与动态重塑机制，研究其与线粒体、脂滴和溶酶体等细胞器之间的功能联系，并进一步探索糖原空间组织如何调控细胞代谢网络与细胞命运。
Glycogen is a major form of intracellular glucose storage and is organized into hierarchical particulate structures. Beyond serving as a glucose reservoir, glycogen particles recruit enzymes and regulatory proteins involved in glycogen metabolism, forming localized metabolic units. Our previous work revealed that glycogen particles in human pluripotent stem cells further assemble into higher-order membraneless metabolic compartments, termed glycogen condensates. By integrating structured illumination super-resolution microscopy with label-free optical diffraction tomography, we investigate how glycogen condensates assemble, localize, and dynamically remodel in living cells. We further explore their functional interactions with mitochondria, lipid droplets, and lysosomes, and how the spatial organization of glycogen regulates cellular metabolic networks and cell fate.
Glycogen is a major form of intracellular glucose storage and is organized into hierarchical particulate structures. Beyond serving as a glucose reservoir, glycogen particles recruit enzymes and regulatory proteins involved in glycogen metabolism, forming localized metabolic units. Our previous work revealed that glycogen particles in human pluripotent stem cells further assemble into higher-order membraneless metabolic compartments, termed glycogen condensates. By integrating structured illumination super-resolution microscopy with label-free optical diffraction tomography, we investigate how glycogen condensates assemble, localize, and dynamically remodel in living cells. We further explore their functional interactions with mitochondria, lipid droplets, and lysosomes, and how the spatial organization of glycogen regulates cellular metabolic networks and cell fate.
代表性论文(# co-first author, * Corresponding author):
1. Weisong Zhao#, Shiqun Zhao#, Liuju Li#, Xiaoshuai Huang, Shijia Xing, Yulin Zhang, Guohua Qiu, Zhenqian Han, Yingxu Shang, De-en Sun, Chunyan Shan, Runlong Wu, Lusheng Gu, Shuwen Zhang, Riwang Chen, Jian Xiao, Yanquan Mo, Jianyong Wang, Wei Ji, Xing Chen, Baoquan Ding, Yanmei Liu, Heng Mao, Bao-Liang Song, Jiubin Tan, Jian Liu, Haoyu Li*, Liangyi Chen*. Sparse deconvolution improves the resolution of live-cell super-resolution fluorescence microscopy. Nature Biotechnology, 2022, 40(4): 606-617.2. Dashan Dong#, Xiaoshuai Huang#, Liuju Li#, Heng Mao, Yanquan Mo, Guangyi Zhang, Zhe Zhang, Jiayu Shen, Wei Liu, Zeming Wu, Guanghui Liu, Yanmei Liu, Hong Yang, Qihuang Gong, Kebin Shi*, Liangyi Chen*. Super-resolution fluorescence assisted diffraction computational tomography reveals the three-dimensional landscape of cellular organelle interactome. Light: Science & Applications, 2020, 9(1): 1-15.
3. Chao Xie#, Liuju Li#, Ming Li#, Wenxin Shao, Qingyu Zuo, Xiaoshuai Huang, Riwang Chen, Wei Li, Melanie Brunnbauer, Zeynep Ökten, Liangyi Chen*, Guangshuo Ou*. Optimal sidestepping of intraflagellar transport kinesins regulates structure and function of sensory cilia. The EMBO Journal, 2020, 39(12): e103955.
4. Zhongtian Yang#, Liuju Li#, Jing Ling, Tianyan Liu, Xiaoshuai Huang, Yuqing Ying, Yun Zhao, Yan Zhao, Kai Lei*, Liangyi Chen*, Zhixing Chen*. Cyclooctatetraene-conjugated cyanine mitochondrial probes minimize phototoxicity in fluorescence and nanoscopic imaging. Chemical Science, 2020, 11(32): 8506-8516.
5. Xiaoshuai Huang#, Junchao Fan#, Liuju Li#, Haosen Liu, Runlong Wu, Yi Wu, Lisi Wei, Heng Mao, Amit Lal, Peng Xi, Liqiang Tang, Yunfeng Zhang, Yanmei Liu, Shan Tan*, Liangyi Chen*. Fast, long-term, super-resolution imaging with Hessian structured illumination microscopy. Nature Biotechnology, 2018, 36(5): 451-459.
