2011年，南开大学生物科学专业，学士学位；
2016年，南开大学生物化学与分子生物学专业，博士学位；
2016-2019年，暨南大学，博士后；
2016-2018年，耶鲁大学，访问学者；
2019-2026年，暨南大学，副研究员；
2026年至今，厦门大学生命科学学院，副教授
B.S. Nankai University, Bioscience,2007-2011;
Ph.D. Nankai University, Biochemistry and Molecular Biology, 2011-2016;
Postdoctoral Fellow, Biomedical Translational Research Institute, Jinan University, 2016-2019;
Visiting Scholar, Yale University, 2016-2018;
Associate Professor, Biomedical Translational Research Institute, Jinan University, 2019-2026;
Associate Professor, School of Life Sciences, Xiamen University, 2026

人体时刻面临着体内体外致病风险因素的侵袭，免疫系统是核心保护屏障。效应性免疫细胞被用于清除致病菌或有致病风险的细胞，而调节性免疫细胞则用于防止过度反应。正常状态下，效应细胞与调节细胞处于动态平衡，维持着机体的健康。免疫稳态的失衡，是导致炎症、自身免疫病、肿瘤等疾病进展的重要原因。本课题组致力于解析Teff等效应性免疫细胞与Treg等调节性免疫细胞的特征与功能；利用条件性基因敲除小鼠等模型，结合细胞生物学、生物化学、分子生物学、多组学等技术手段，解析炎症、自身免疫病、肿瘤等免疫相关疾病的病理机制。
Human beings are constantly exposed to environmental pathogens such as virus and endogenous damages such as gene mutation, yet we can maintain health in most circumstances largely due to the immune system. Effector immune cells can eliminate pathogens and pathogenic cells, while regulatory immune cells prevent excessive reactions during this process. Under normal conditions, effector cells and regulatory cells maintain a dynamic balance. The imbalance of immune homeostasis leads to inflammation, autoimmune diseases, tumors, et al. My lab is dedicated to elucidating the characteristics and functions of Teff subsets and Tregs. By using conditional gene knockout mice, combined with cell biology, biochemistry, molecular biology, and multi-omics techniques, we aim to understand the pathological mechanisms of immune-related diseases such as inflammation, autoimmune diseases, and tumors.

代表性论文(^# co-first author, ^* Corresponding author):

1. Yan J^#, Zeng Y^#, Guan Z^#, Li Z^#, Luo S^#, Niu J^#, Zhao J^#, Gong H, Huang T, Li Z, Deng A, Wen Q, Tan J, Jiang J, Bao X, Li S, Sun G, Zhang M, Zhi M^*, Yin Z^*, Sun WY^*, Li YF^*, He RR^*, Cao G^*. Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Rep. 2024 Aug 27;43(8):114636.
2. Zhu L^#, Xia X^#, Li G^#, Zhu C^#, Li Q, Wang B, Shi NX, Lei Z, Yang S, Zhang Z, Li H, Tan J, Liu Z, Wen Q, Zhong H, Lin XJ, Sun G, Bao X, Wang Q^*, Deng L^*, Bin L^*, Cao G^*, Yin Z^*. SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification. Cell Rep. 2023 Aug 29;42(8):112910.
3. Xiao Z^#, Wang S^#, Tian Y^#, Lv W, Sheng H, Zhan M, Huang Q, Zhang Z, Zhu L, Zhu C, Zhong H, Wen Q, Liu Z, Tan J, Xu Y, Yang M, Liu Y^*, Flavell RA^*, Yang Q^*, Cao G^*, Yin Z^*. METTL3-mediated m6A methylation orchestrates mRNA stability and dsRNA contents to equilibrate γδ T1 and γδ T17 cells. Cell Rep. 2023 Jul 25;42(7):112684.
4. Li D^#, Zhu J^#, Zhang M^#, Shi Q^#, Guo R^#, Zhang D, Zheng P, Zhang H, Li G, Wu J, Sun G, Wen Q, Tan J, Liu Z, Liu X, Yang H^*, Lu H^*, Cao G^*, Yin Z^*, Wang Q^*. SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance. Cell Rep. 2025 Apr 22;44(4):115496.
5. Wang Q^#, Li D^#, Cao G^#, Shi Q^#, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L^*, Yang H^*, Flavell RA^*, Yin Z^*. IL-27 signalling promotes adipocyte thermogenesis and energy expenditure. Nature. 2021 Dec;600(7888):314-318.
6. Li Z^#, Yang Q^#, Tang X^#, Chen Y, Wang S, Qi X, Zhang Y, Liu Z, Luo J, Liu H, Ba Y, Guo L, Wu B, Huang F, Cao G^*, Yin Z^*. Single-cell RNA-seq and chromatin accessibility profiling decipher the heterogeneity of mouse γδ T cells. Sci Bull. 2022 Feb 26;67(4):408-426.
7. Luo S^#, Zeng Y^#, Chen B^#, Yan J, Ma F, Zhuang G, Hao H, Cao G^*, Xiao X^*, Li S^*. Vitamin E and GPX4 cooperatively protect Treg cells from ferroptosis and alleviate intestinal inflammatory damage in necrotizing enterocolitis. Redox Biol. 2024 Sep;75:103303.
8. Zhang M^#, Li D^#, Zhu J^#, Xia X, Zhang H, Wu J, Wang S, Deng A, Wen Q, Tan J, Hao J, Jiang J, Bao X, Sun G, Lu J, Yang Q, Yang H^*, Cao G^*, Yin Z^*, Wang Q^*. IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation. Cell Death Dis. 2024 Jul 9;15(7):491.
9. Lu J, Jiao Y, Cao G^*, Liu Z^*. Multimode CaCO3/pneumolysin antigen delivery systems for inducing efficient cellular immunity for anti-tumor immunotherapy. Chemical Engineering Journal. 2021 Sep 15; 420(1): 129746.
10. Zhu L^#, Lei Z^#, Xia X^#, Zhang Y, Chen Y, Wang B, Li J, Li G, Yang G, Cao G^*, Yin Z^*. Yeast Shells Encapsulating Adjuvant AS04 as an Antigen Delivery System for a Novel Vaccine against Toxoplasma Gondii. ACS Appl Mater Interfaces. 2021 Sep 1;13(34):40415-40428.
11. Li P^#, Zhu X^#, Cao G^#, Wu R, Li K, Yuan W, Chen B, Sun G, Xia X, Zhang H, Wang X, Yin Z^*, Lu L^*, Gao Y^*. 1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. J Immunother Cancer. 2022 Mar;10(3):e003477.
12. Xia X^#, Cao G^#, Sun G^#, Zhu L, Tian Y, Song Y, Guo C, Wang X, Zhong J, Zhou W, Li P, Zhang H, Hao J, Li Z, Deng L^*, Yin Z^*, Gao Y^*. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis. J Clin Invest. 2020 Oct 1;130(10):5180-5196.
13. Tong J^#, Cao G^#, Zhang T^#, Sefik E, Amezcua Vesely MC, Broughton JP, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA^*, Li HB^*. m6A mRNA methylation sustains Treg suppressive functions. Cell Res. 2018 Feb;28(2):253-256.
14. Sun G^#, Yang S^#, Cao G^#, Wang Q, Hao J, Wen Q, Li Z, So KF, Liu Z, Zhou S, Zhao Y, Yang H, Zhou L^*, Yin Z^*. γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury. J Exp Med. 2018 Feb 5;215(2):521-535.
15. Cao G^#, Wang Q^#, Huang W^#, Tong J, Ye D, He Y, Liu Z, Tang X, Cheng H, Wen Q, Li D, Chau HT, Wen Y, Zhong H, Meng Z, Liu H, Wu Z, Zhao L, Flavell RA, Zhou H, Xu A, Yang H^*, Yin Z^*. Long-term consumption of caffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE in mice. Cell Discov. 2017 Jun 20;3:17020.
16. Cao G^#, Wang Q^#, Li G, Meng Z, Liu H, Tong J, Huang W, Liu Z, Jia Y, Wei J, Chi H, Yang H, Zhao L, Wu Z, Hao J^*, Yin Z^*. mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α. J Leukoc Biol. 2016 Nov;100(5):1181-1189.
17. Cao G^#, Li HB^#, Yin Z^*, Flavell RA^*. Recent advances in dynamic m6A RNA modification. Open Biol. 2016 Apr;6(4):160003. Review.

荣誉、奖励及参加学术团体的情况:

2022年，获广东省杰出青年基金项目资助；
2022年，中国医学科学院，“中国2021年度重要医学进展”
2025年，Military Medical Research杂志，青年编委；
2026年，Science Bulletin杂志，青年编委。