2018年，华中农业大学生物科学专业，学士学位；
2023年，北京大学生物化学与分子生物学专业，博士学位；
2023-2026年，北京大学生物化学与分子生物学专业，博士后；
2026年，厦门大学生命科学学院，教授
B.S. Huazhong Agricultural University, Biological Sciences, 2018;
Ph.D. Peking University, Biochemistry and Molecular Biology, 2023;
Postdoctoral Fellow, Peking University, Biochemistry and Molecular Biology, 2026;
Professor, School of Life Sciences, Xiamen University, 2026

RNA化学修饰在基因表达调控、细胞命运决定等关键生命过程中发挥“分子开关”作用，不仅拓展了RNA生物学的研究边界，也揭示了全新的调控机制与研究方向。RNA修饰在多种生理与病理过程中具有关键调控功能，使其相关通路与因子成为重要的诊疗靶点，为疾病干预提供新的策略与切入点。当前，RNA修饰研究处于快速发展但机制尚未充分解析的阶段，亟需在新技术、新功能与新机制方面持续突破。基于此，课题组拟开展如下研究方向：1. 发展空间单细胞核酸修饰多组学检测技术，解析核酸修饰在组织微环境中的时空异质性与特异性分布规律；2. 推进多学科交叉融合研究，构建并阐明核酸修饰在重要生理与病理过程中的动态调控网络与功能图谱；3. 聚焦细胞表面RNA修饰，系统解析其发生机制，建立检测方法，阐明生物学功能，并探索可操控与应用转化的策略。
RNA chemical modifications function as“molecular switches”in essential life processes such as the regulation of gene expression and cell fate determination, not only expanding the boundaries of RNA biology but also revealing entirely new regulatory mechanisms and research directions. Across diverse physiological and pathological contexts, RNA modifications exert critical regulatory functions, making their associated pathways and factors important diagnostic and therapeutic targets and providing new strategies for disease intervention. Although the field of RNA modification research is developing rapidly, many underlying mechanisms remain insufficiently understood, highlighting an urgent need for continued breakthroughs in new technologies, functions, and mechanisms. To this end, our research group will focus on the following directions: 1. Develop spatial single-cell multi-omics technologies to delineate the spatiotemporal heterogeneity and context-specific distribution patterns of RNA modifications within tissue microenvironments. 2. Promote multidisciplinary, integrative research to construct and elucidate dynamic regulatory networks and functional maps of nucleic acid modifications in key physiological and pathological processes. 3. Focus on cell-surface RNA modifications to systematically dissect their mechanisms of occurrence, establish detection methods, clarify their biological functions, and explore strategies for controllable manipulation and applications.

代表性论文(^# co-first author, ^* Corresponding author):

1. Sun H.^#, Lu B.^#, Zhang Z.^#, Xiao Y., Zhou Z., Xi L., Li Z., Jiang Z., Zhang J., Wang M., Liu C., Ma Y., Peng J., Wang X.-J.^* & Yi C.^* Mild and ultrafast GLORI enables absolute quantification of m6A methylome from low-input samples. Nature Methods, 22, 1226-1236 (2025)
2. Sun H.^#, Teng Q.^#, Liu W.^#, Guo R.^#, Li M.^#, Xiong W., Huang Q., Yu Q., Luo N., Li Y., Song J., Gong S., Shi X.^*, Yi C.^* & Liu K.^* CRISPR-free RNA Base Editing Mediated PTC-readthrough Restores Hearing in Mice with Otof Nonsense Mutation. Nature Communications, 17, 413 (2026)
3. Shen W.^#, Sun H.^#, Liu C.^#, Yi Y., Hou Y., Xiao Y., Hu Y., Lu B., Peng J., Wang J.^* & Yi C.^*. GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution. Nature Protocols 19, 1252-1287 (2024).
4. Sun H.^#, Li K.^#, Liu C.^# & Yi C.^* Regulation and functions of non-m6A mRNA modifications. Nature Reviews Molecular Cell Biology, 24, 714-731 (2023).
5. Liu C.^#, Sun H.^#, Yi Y.^#, Shen W.^#, Li K.^#, Xiao Y., Li F., Li Y., Hou Y., Lu B., Liu W., Meng H., Peng J., Yi C.^* & Wang J.^* Absolute quantification of single-base m6A methylation in the mammalian transcriptome using GLORI. Nature Biotechnology, 41, 355–366 (2023).
6. Song J.^#, Dong L.^#, Sun H.^#, Luo N.^#, Huang Q.^#, Li K., Shen X., Jiang Z., Lv Z., Peng L., Zhang M., Wang K., Liu K., Hong J. & Yi C.^* CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons. Molecular Cell 83, 139–155 (2023).
7. Sun H.^#, Li K.^#, Zhang X., Liu J., Zhang M., Meng H. & Yi, C.^* m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome. Nature Communications, 12, 4778 (2021).
8. Sun H.^#, Zhang M.^#, Li K., Bai D. & Yi C.^* Cap-specific, terminal N6-methylation by a mammalian m6Am methyltransferase. Cell Research, 29, 80–82 (2019).

荣誉、奖励及参加学术团体的情况:

2023年 吴瑞奖学金
2025年 青稞π·青年科学家论坛-新锐奖
2025年 全国医学细胞生物学优秀青年学者
2023年 北京市普通高等学校优秀毕业生
2023年 北京大学优秀博士学位论文
2023年 北京大学优秀毕业生张景钺奖
2022年 国家奖学金
2022年 中国生物化学与分子生物学学会-罗氏大学研究基金二等奖
2022年 北京大学研究生校长奖学金
2021年 北京大学廖凯原奖学金
2019年 国家奖学金