2013年，福建师范大学生物技术专业，学士学位；
2020年，厦门大学生物化学与分子生物学专业；博士学位；
2020-2023年，厦门大学，博士后；
2023-2025年，香港大学，博士后；
2025年，厦门大学生命科学学院，助理教授
B.S. 2013, Fujian Normal University, Biotechnology;
Ph.D. 2020, Xiamen University, Biochemistry and molecular biology;
Postdoctoral Fellow, Xiamen University, 2020-2023;
Postdoctoral Fellow, The University of Hong Kong, 2023-2025;
Assistant Professor, School of Life Sciences, Xiamen University, 2025

聚焦肿瘤治疗与免疫学，解析肿瘤微环境与免疫逃逸机制，开发免疫检查点阻断、细胞免疫疗法与肿瘤疫苗等创新策略，并通过分子靶点筛选与临床前模型推动生物标志物与联合治疗的临床转化。
Our research focuses on cancer therapy and immunology, dissecting the tumor microenvironment and mechanisms of immune evasion, developing innovative strategies such as immune checkpoint blockade, cell‑based immunotherapies, and cancer vaccines, and advancing biomarkers and combination therapies toward clinical translation through molecular target screening and preclinical models.

代表性论文(^# co-first author, ^* Corresponding author):

1. Huanhuan Ma^#, Vanilla Xin Zhang^#, Yu Man Tsui, Joyce Man-Fong Lee, Eva Lee, Jingyi Lu, Huan Deng, Fanhong Zeng, Daniel Wai-Hung Ho, Abdullah Husain, Charry Hui, Karen Man-Fong Sze, Irene Oi-Lin Ng^*, Targeting sterol O-acyltransferase 1 rewires fatty acid metabolism and uncovers immune vulnerability in hepatocellular carcinoma, Hepatology, 2025 Oct, Epub ahead of print
2. Huanhuan Ma^#, Tingyan Cao^#, Fengqiong Zhang^#, Dachao Sun, Lili Chen, Yao Lin, Shuqing Lai, Bin Jiang, Yanming Zhou, Jun You, Xiyao Liu, Yue Wang, Furong Lin, Yuxin Liu, Jinyang Wang, Weiling He^* and Qinxi Li^*, Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor, Gut, 2025 Jun. Epub ahead of print
3. Huanhuan Ma^#, Muhammad Suleman^#, Fengqiong Zhang^#, Tingyan Cao, Shixiong Wen, Dachao Sun, Lili Chen, Bin Jiang, Yue Wang, Furong Lin, Jinyang Wang, Boan Li^* and Qinxi Li^*, Pirin inhibits FAS-mediated apoptosis to support colorectal cancer survival, Advanced Science, 2024 Mar, 11(10):e2301476
4. Huanhuan Ma, Jia Zhang, Lin Zhou, Shixiong Wen, Hsiang-Yu Tang, Bin Jiang, Fengqiong Zhang, Muhammad Suleman, Dachao Sun, Ai Chen, Wentao Zhao, Furong Lin, Ming-Tong Tsau, Lu-Min Shih, Changchuan Xie, Xiaotong Li, Donghai Lin, Li-Man Hung^*, Mei-Ling Cheng^*, Qinxi Li^*, c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3, Cell Reports, 2020, 30(12): 4235-4249.e6
5. Ma Huanhuan^#, Zhang Fengqiong^#, Zhou Lin, Cao Tingyan, Sun Dachao, Wen Shixiong, Zhu Jinpei, Xiong Zhaoqianyu, Tsau Ming-Tong, Cheng Mei-Ling, Hung Li-Man, Zhou Yanming, Li Qinxi^*, c-Src facilitates tumorigenesis by phosphorylating and activating G6PD, Oncogene, 2021, 40(14): 2567-2580
6. Fanhong Zeng^#, Qingyang Zhang^#, Yu-Man Tsui, Huanhuan Ma, Lu Tian, Abdullah Husain, Jingyi Lu, Joyce Man-Fong Lee, Vanilla Xin Zhang, Po-Man Li, Gary Cheuk-Hang Cheung, Tan-To Cheung, Daniel Wai-Hung Ho^*, Irene Oi-Lin Ng^*, Multimodal sequencing of neoadjuvant nivolumab treatment in hepatocellular carcinoma reveals cellular and molecular immune landscape for drug response, Molecular Cancer, 2025, 24(110)
7. Yu-Man Tsui^#, Lu Tian^#, Jingyi Lu, Huanhuan Ma, Irene Oi-Lin Ng^*, Interplay among extracellular vesicles, cancer stemness and immune regulation in driving hepatocellular carcinoma progression, Cancer Letters, 2024, 597:217084
8. Jiang B^#, Zhang J^#, Zhao G^#, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q^*. Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. Molecular Cell, 2022, 82(10):1821-1835.e6.

荣誉、奖励及参加学术团体的情况: