2011年，南开大学生物科学专业，学士学位；
2016年，香港大学化学生物学专业，博士学位；
2016-2021年，香港大学理学院，博士后；
2021-2025年，香港大学李嘉诚医学，研究助理教授；
2024年，国家高层次青年人才
2024年，厦门大学南强青年拔尖A类人才
2025年，厦门大学生命科学学院，教授
B.S. Biological Sciences, Nankai University, 2011;
Ph.D. Chemical Biology, The University of Hong Kong, 2016;
Postdoctoral Fellow, Faculty of Science, The University of Hong Kong, 2016-2021;
Research Assistant Professor, LKS Faculty of Medicine, The University of Hong Kong, 2021-2025;
Professor, School of Life Sciences, Xiamen University, 2025

作为生命体系基本“元件”的生物大分子（蛋白质、核酸、糖脂等）时刻处于修饰位点与种类多变、时空特异和双向可逆的化学修饰之中。生物大分子化学修饰的动态属性在生物体的生理活动和病理变化中通常都发挥着关键作用。其中，蛋白质是生命活动的主要执行者。研究蛋白质化学修饰和互作网络的时空动态变化，是解析机体生理或病理进程的关键。我们的研究集中在化学生物学与蛋白质组学的交叉领域，致力于开发用于研究蛋白质翻译后修饰和蛋白质互作网络的化学生物学工具，以破译微环境中蛋白质翻译后修饰的生物学功能及其调节机制，探索微环境中的细胞间通讯和蛋白质互作机制，以期发现疾病治疗新靶标和新策略。
欢迎有兴趣的学生和青年学者加入我们的研究团队！
As the basic "elements" of the living system, biological macromolecules (proteins, nucleic acids, glycolipids, etc.) are always chemically modified with variable modification sites and types, spatiotemporal specificity, and bidirectional reversibility. The dynamic properties of chemical modifications of biological macromolecules often play a key role in both physiological activities and pathological processes. Among them, proteins are the main executors of life activities. The study of the spatiotemporal dynamics of protein posttranslational modifications (PTMs) and protein-protein interaction (PPI) networks is the key to analyzing the physiological or pathological processes of the body. Our research focuses on the intersection of chemical biology and proteomics to develop chemical biology tools for studying protein PTMs and PPI networks, to decipher the biological functions of protein PTMs and their regulatory mechanisms, and to explore cell-to-cell communication and PPI mechanisms in the microenvironment, aiming to discover new targets for disease treatment and translate basic biomedical discoveries into effective therapies for human diseases.
We are actively recruiting postgraduate students, research assistants, and postdocs to join our lab. Please email Dr. Xiucong Bao (baoxc@xmu.educ.cn) directly for potential projects.

代表性论文(^# co-first author, ^* Corresponding author):

1. S. Huang^#, Q. Ran^#, X. M. Li, X. Bao^*, C. Zheng^*, X. D. Li^*. MACSPI enables tissue-selective proteomic and interactomic analysis in multicellular organisms. PNAS. 2024 May 21;121(21):e2319060121.
2. J. Lee, X. Bao^*. Comparative Review on Cancer Pathology from Aberrant Histone Chaperone Activity. Int J Mol Sci. , 2024 Jun 10;25(12):6403.
3. J. Lin^#, Y. Wu^#, G. Tian^#, D. Yu^#, E. Yang, W. H. Lam, Z. Liu, Y. Jing, S. Dang, X. Bao^*, J. W. H. Wong^*, Y. Zhai^*, X. D. Li^*. Menin "reads" H3K79me2 mark in a nucleosomal context. Science. 2023 Feb 17;379(6633):717-723.
4. J. Lin, X. Bao^*, X. D. Li^*. Chemoproteomic approach for mapping binding sites of post-translational-modification-mediated protein-protein interactions. Trends Biochem Sci. 2021 Dec;46(12):1030-1031.
5. Q. Wang^#, X. Bao^#, S. Chen, H. Zhong, Y. Liu, L. Zhang, Y. Xia, F. Kragler, M. Luo, X. D. Li, H. M. Lam, S. Zhang^*. AtHDA6 functions as an H3K18ac eraser to maintain pericentromeric CHG methylation in Arabidopsis thaliana. Nucleic Acids Res. 2021. Sep 27;49(17):9755-9767.
6. J. Lin, X. Bao^*, X. D. Li^*. A tri-functional amino acid enables mapping of binding sites for posttranslational modification-mediated protein-protein interactions. Mol Cell. 2021 Jun 17;81(12):2669-2681.e9.
7. X. Bao. Study on the cellular regulation and function of lysine malonylation, glutarylation and crotonylation. Springer Theses. 2020. ISBN 978-981-15-2509-4.
8. X. Bao, Z. Liu, W. Zhang, K. Gladysz, Y. M. E. Fung, G. Tian, Y. Xiong, J. W. H. Wong^*, K. W. Y. Yuen^*, X. D. Li^*. Glutarylation of histone H4 lysine 91 regulates chromatin dynamics. Mol Cell. 2019 Nov 21;76(4):660-675.e9.
9. X. Bao, Y. Xiong, X. Li, X. D. Li^*. A chemical reporter facilitates the detection and identification of lysine HMGylation on histones. Chem Sci. 2018 Aug 28;9(40):7797-7801.
10. X. Bao^#, Y. Wang^#, X. Li^#, X. M. Li^#, Z. Liu, T. Yang, C. F. Wong, J. Zhang, Q. Hao^* and X. D. Li^*. Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. eLife. 2014, Nov 4:3:e02999.
11. X. Bao^#, Q. Zhao^#, T. Yang, Y. M. E. Fung^* and X. D. Li^*. A chemical probe for lysine malonylation. Angew. Chem. Int. Ed. , 2013, Apr 26; 52(18), 4883-4886.
12. V. Gray, W Chen, R. Tan, T Teo, Z. Huang, C. Fong, T. Law, Z. Ye, S. Yuan, X. Bao, I. Hung, K. Tan^*, C. Lee^*, G. Ling^*. Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in Type 2 Diabetes. Cell Metab. 2024 Oct 25:S1550-4131(24)00400-5.
13. J. Yan, Y. Zeng, Z. Guan, Z. Li, S. Luo, J. Niu, J. Zhao, H. Gong, T. Huang, Z. Li, A.Deng, Q. Wen, J. Tan, J. Jiang, X. Bao, S. Li, G. Sun, M. Zhang, M. Zhi^*, Z. Yin^*, W.Y. Sun^*, Y.F. Li^*, R.R. He^*, G. Cao^*. Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Rep. 2024 Aug 16;43(8):114636.
14. M. Zhang^#, D. Li^#, J. Zhu, H. Zhang, J. Wu, S. Wang, A. Deng, Q. Wen, J. Tan, X. Bao, J. Lu, Q. Yang, H Yang^*, G. Cao^*, Z. Yin^*, Q. Wang^*. IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation. Cell Death Dis. 2024 Jul 9;15(7):491.
15. L. Zhu^#, X. Xia^#, G. Li^#, C. Zhu^#, Q. Li, B. Wang, N.X. Shi, Z. Lei, S. Yang, Z. Zhang, H. Li, J. Ta, Z. Liu, Q. Wen, H. Zhong, X.J. Lin, G. Sun, X. Bao, Q. Wang^*, L. Deng^*, L. Bin^*, G. Cao^*, Z. Yin^*. SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification. Cell Rep. 2023 Aug 29;42(8):112910.
16. X. Li, Y. Wu, G. Tian, Y. Jiang, Z. Liu, X. Meng, X. Bao, L. Feng, H. Sun, H. Deng, X. D. Li^*. Chemical proteomic profiling of bromodomains enables the wide-spectrum evaluation of bromodomain inhibitors in living cells. J Am Chem Soc. 2019 Jul 24;141(29):11497-11505.
17. Y. Jing, Z. Liu, G. Tian, X. Bao, T. Ishibashi, X. D. Li^*. Site-specific installation of succinyl lysine analog into histones reveals the effect of H2BK34 succinylation on nucleosome dynamics. Cell Chem Biol. 2018 Feb 15;25(2):166-174.e7.
18. X. Xie, X. M. Li, F. Qin, J. Lin, G. Zhang, J. Zhao, X. Bao, R. Zhu, H. Song, X. D. Li^*, P. R. Chen^*. Genetically encoded photoaffinity histone marks. J Am Chem Soc. 2017 May 17;139(19):6522-6525.
19. T. Yang, X. M. Li, X. Bao, Y. M. E. Fung and X. D. Li^*. Photo-lysine captures proteins that bind lysine post-translational modifications. Nat Chem Biol. 2016 Feb;12(2):70-2.
20. T. Wen, Y. Li, M. Wu, X. Chen, L. Han, X. Bao, Z. Wang, K. Wang, Y. Hu, X. Zhou, Z. Wu, P. Wang, Z. Hong, L. Zhao, Q. Wang^*, Z. Yin^*. A novel tylophorine analog NK-007 ameliorates colitis through inhibition of innate immune response. Int Immunopharmacol. 2012 Dec;14(4):487-94.
21. T. Wen, Y. Li, M. Wu, X. Sun, X. Bao, Y. Lin, J. Hao, L. Han, G. Cao, Z. Wang, Y. Liu, Z. Wu, Z. Hong, P. Wang, L. Zhao, Z. Li, Q. Wang^*, Z. Yin^*. Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation. Arthritis Rheum. 2012 Sep;64(9):2896-906.

荣誉、奖励及参加学术团体的情况:

2017 Outstanding Research Postgraduate Student, The University of Hong Kong
2017 Springer Thesis Prize, Springer Nature
2017 Poster Award at Symposium on Chromatin Biology held by the Chinese Society for Cell Biology
2015 Poster Award at Symposium “Frontiers in Chromatin Biology and Chemical Epigenetics-Epigenomics”
2014 Poster Award at Hong Kong Inter-University Biochemistry Postgraduate Symposium
2010 National Encouragement Scholarship
2009 First Prize in the Basic Experimental Skills Competition, Tianjin
2009 Scholarship of Academic Excellence, Nankai University
2008 Scholarship of Academic Excellence, Nankai University