2011年，山东大学生物技术专业，学士学位；
2016年，中科院生物物理研究所细胞生物学专业，博士学位；
2016-2018年，中科院生物物理研究所，助理研究员；
2018-2023年，耶鲁大学免疫学系，博士后；
2023-2024年，耶鲁大学免疫学系，副研究员；
2024年，国家高层次青年人才;
2025年，厦门大学南强青年拔尖A类人才;
2025年，厦门大学生命科学学院，教授。
B.S. Shandong University, Biotechnology, 2011;
Ph.D. Institute of Biophysics, Chinese Academy of Science, Cell Biology, 2016;
Assistant Research Scientist, Institute of Biophysics, Chinese Academy of Science, 2016-2018;
Postdoctoral Fellow, Department of Immunobiology, Yale University, 2018-2023;
Associate Research Scientist, Department of Immunobiology, Yale University, 2023-2024;
Professor, School of Life Sciences, Xiamen University, 2025

中枢神经系统具有特定的解剖学结构、组织微环境以及独特的免疫监视机制，被认为是免疫豁免器官。而近些年的研究显示神经系统和免疫系统之间存在着双向且复杂的相互作用，在机体感知内外环境的刺激和维持生理稳态的过程中发挥主导作用。免疫系统参与中枢神经系统的发育并且参与在生理和病理条件下中枢神经系统功能的调节。本课题组将致力于解析神经系统-免疫系统互作与调控的独特机制，阐释特定微环境、免疫细胞群、免疫器官以及淋巴管在调节神经系统的功能中所发挥的作用。我们的研究不仅能够深化对中枢神经系统的独特免疫机制这一科技前沿问题的理解，同时对于中枢神经系统的感染、肿瘤、神经退行性疾病等疾病的治疗都具有指导意义和临床应用价值。
The central nervous system has specific anatomical structure, tissue microenvironment, and unique immune surveillance mechanism and is considered a relatively immune-privileged organ However, it is now established that the nervous system and the immune system possess a bidirectional and complex interaction, which plays a pivotal role in the perception of internal and external environmental stimuli and the maintenance of physiological homeostasis. The immune system participates in the development of the central nervous system and regulate the central nervous system function in both physiological and pathophysiological condition. Our research team is dedicated to unraveling the unique mechanisms underlying the interaction and regulation between the nervous system and the immune system, elucidating the roles of specific microenvironments, immune cell populations, immune organs, and lymphatic vessels in modulating the functions of the nervous system. Our research not only uncovers the cutting-edge scientific issue of the unique immune mechanisms of the central nervous system but also have direct potential for being implemented in the treatment of central nervous system infections, tumors, neurodegenerative diseases, and other related conditions.

代表性论文(^# co-first author, ^* Corresponding author):

1) Xiangyun Yin^#; Sophia Zhang^#; Ju Hyun Leev; Huiping Dong; George Mourgkos; Gordon Terwilliger; Aurora Kraus; Luiz Henrique Geraldo; Mathilde Poulet; Suzanne Fischer; Ting Zhou; Farrah Shalima Mohammed; Jiangbing Zhou; Yongfu Wang; Seth Malloy; Nicolas Rohner; Lokesh Sharma; Irene Salinas; Anne Eichmann; Jean-Leon Thomas; W. Mark Saltzman; Anita Huttner; Caroline Zeiss; Aaron Ring; Akiko Iwasaki; Eric Song ; Compartmentalized ocular lymphatic system mediates eye–brain immunity, Nature, 2024, 628(8006): 204-211. (^# equal contribution).
2) Dong Liu^#, Xiangyun Yin^#, Sam J. Olyha, Manuela Sales L. Nascimento, Pei Chen, Theresa White, Uthaman Gowthaman, Jake A. Gertie, Biyan Zhang, Lan Xu, Marina Yurieva, Lesley Devine, Adam Williams,^* Stephanie C. Eisenbarth,^* IL-10-dependent crosstalk between murine marginal zone B cells, macrophages and CD8α+ dendritic cells promotes Listeria monocytogenes infection. Immunity, 2019 Jul 16;51(1):64-76.e7. (^# equal contribution).
3) Xiangyun Yin, Shuting Chen, and Stephanie C. Eisenbarth. Dendritic Cell Regulation of T Helper Cells. Annual Review of Immunolog, 2021,39: 759-90.
4) Elise G Liu ^#, Xiangyun Yin ^#, Emily R Siniscalco, Stephanie C Eisenbarth. Dendritic cells in food allergy, treatment, and tolerance. Journal of Allergy and Clinical Immunology. 2024 Sep;154(3):511-522. (^# equal contribution).
5) Elise G. Liu^#, Xiangyun Yin^# , Anush Swaminathan and Stephanie C. Eisenbarth. Antigen-Presenting Cells in Food Tolerance and Allergy. Frontiers in Immunology, 2020, 11: 616020. (^# equal contribution).
6) Xiangyun Yin, Stephanie C Eisenbarth. Torn between type 1 and type 2 immunity. Science Immunology. 2020 Nov 6;5(53):eabf4905.
7) Xiangyun Yin, Stephanie C Eisenbarth. Escape from the pore. Science Immunology. 2023 Aug 4;8(86):eadj9549.
8) Xiangyun Yin, Haisheng Yu, Jinxiao Yang, Jingyun Li, Hao Guo, Quanxing Shi, Zhao Yin, Xu Yong, Xuefei Wang, Rong Liu, Shouli Wang, Liguo Zhang. Human blood CD1c+ dendritic cells encompass two subsets that differ significantly in phenotype, gene expression and functions. Journal of Immunology, 2017, 198(4): 1553-64.
9) Biyan Zhang^#; Shuting Chen^#; Xiangyun Yin; Caleb D. McBride; Jake A. Gertie; Marina Yurieva; Agata A. Bielecka; Brian Hoffmann; Travis Hinson; Jessica Grassmann; Lan Xu; Emily R. Siniscalco; Arielle Soldatenko; Laura Hoyt; Julie Joseph; Elizabeth B. Norton; Gowthaman Uthaman; Noah W. Palm; Elise Liu; Stephanie C. Eisenbarth; Adam William. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8, Mucosal Immunology. 2024 Jun;17(3):431-449.
10) Ligia Simoes Braga Boisserand; Luiz Henrique Geraldo; Jean Bouchart; Marie-Renee El Kamouh; Seyoung Lee; Basavaraju G. Sanganahalli; Myriam Spajer; Shenqi Zhang; Sungwoon Lee; Maxime Parent; Yuechuan Xue; Mario Skarica; Xiangyun Yin; Justine Guegan; Kevin Boyé; Felipe Saceanu Leser; Laurent Jacob; Mathilde Poulet; Mingfeng Li; Xiodan Liu; Sofia E. Velazquez; Ruchith Singhabahu; Mark E. Robinson; Michael H. Askenase; Artem Osherov; Nenad Sestan; Jiangbing Zhou; Kari Alitalo; Eric Song; Anne Eichmann; Lauren H. Sansing; Helene Benveniste; Fahmeed Hyder; Jean-Leon Thomas. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model, Journal of Experimental Medicine. 2024 Apr 1;221(4):e20221983.
11) Jake A. Gertie, Biyan Zhang, Elise G. Liu, Laura R. Hoyt, Xiangyun Yin, Lan Xu, Lauren L. Long, Arielle Soldatenko, Uthaman Gowthaman, Adam Williams, and Stephanie C. Eisenbarth, 2021. Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations. Journal of Allergy and Clinical Immunology, 2021 May 27;S0091-6749(21)00820-4.
12) Haisheng Yu, Peng Zhang, Xiangyun Yin, Zhao Yin, Quanxing Shi, Ya Cui, Shouli Wang, Pier Paolo Piccaluga, Taijiao Jiang, Liguo Zhang. Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid dendritic cell neoplasm represent a unique myeloid DC subset. 2015, Protein & cell 6: 297-306.
13) Hao Guo, Jialong Zhang, Xuyuan Zhang, Yanbing Wang, Haisheng Yu, Xiangyun Yin, Jingyun Li, Peishuang Du, Joël Plumas, Laurence Chaperot, Jianzhu Chen, Lishan Su, Yong-jun Liu, Zhang Liguo^*, SCARB2/LIMP-2 regulates IFN production of plasmacytoid dendritic cells by mediating endosomal translocation of TLR9 and nuclear translocation of IRF7, Journal of Immunology, 2015, 194 (10): 4737-4749. (IF=5.4)

荣誉、奖励及参加学术团体的情况:

2023 Poster award of Gordon Research Conference
2019 The Richard K. Gershon Research Fellowship
2016-2017 Outstanding staff, Chinese Academy of Science
2009-2010 Merit students, Shandong University
2008-2009 Shandong University Merit Scholarship
2007-2008 National Endeavor Scholarship