2014年，中山大学 高分子材料与工程专业，学士学位；
2019年，中国科学院 上海有机化学研究所 化学生物学方向，博士学位；
2019-2024年，康奈尔大学 威尔康奈尔医学院，博士后；
2024年，国家高层次青年人才
2024年，厦门大学南强青年拔尖A类人才
2024年，厦门大学生命科学学院，教授
B.S. Polymer Material and Engineering, Sun Yat-Sen University, 2014;
Ph.D. Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 2019;
Postdoctoral Fellow, Cornell University, Weill Cornell Medicine, 2019-2024;
Professor, School of Life Sciences, Xiamen University, 2024

肠道是人体内最大的免疫器官，庞大的肠道菌群通过与宿主的长期协同进化，已经成为一个与人体密不可分的重要“隐形器官”，是人体重要的免疫屏障。肠道微生物的基因及其对应的初级/次级代谢产物对宿主的生理功能有深远影响，并与多种疾病的发生发展密切相关，肠道微生物对药物的代谢显著影响药效。课题组致力于利用基因编辑技术改造肠道菌群，对肠道微生物-代谢产物/药物-宿主之间的相互作用进行分子机制层面的深入探索。具体的研究方向有：1）以疾病特异性积累或缺失的肠道菌代谢物为导向，揭示肠道菌通过特定代谢物影响宿主疾病的机制；2）挖掘肠道菌群新型次级代谢产物并考察其对宿主生理功能的影响；3）研究肠道菌群的药物代谢，并应用于药物优化，为创新药物发展提供新策略。
Human gut represents the largest immune system within the host. Through long-term co-evolution with the host, the gut microbiota has become an important "invisible organ" which is essential for the human body and acts as an important immune barrier. The functional genes of gut microbes and their corresponding primary/secondary metabolites have a profound impact on host biology, and are closely related to the occurrence and development of a variety of diseases. Also, gut microbiota significantly affects the metabolism of drugs. Our group develop genetic manipulation tools for gut microbiota to investigate the underlying molecular mechanism of the gut microbiome - metabolite/drug - host interactions. 1) Focusing on the gut bacteria-derived metabolites accumulated/depleted within patients with different diseases, our group will explore their impacts on host biology and diseases at the level of molecular mechanism, paving the way for better precision medicine against those diseases; 2) our group will characterize cryptic secondary metabolites produced by gut microbes, and study their effects on the host biology and diseases; 3) we will investigate drug metabolism by gut bacteria, shedding light on the development of new drugs.

代表性论文(^# co-first author, ^* Corresponding author):

1. Wen-Bing Jin*; Chun-Jun Guo*; Genetic manipulations of nonmodel gut microbes, iMeta, 2024, e216, https://doi.org/10.1002/imt2.216
2. Wen-Bing Jin; Ting-Ting Li; Da Huo; Sophia Qu; Xin V. Li; Mohammad Arifuzzaman; Svetlana F. Lima; Hui-Qing Shi; Aolin Wang; Gregory G. Putzel; Randy S. Longman; David Artis; Chun-Jun Guo*; Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome, Cell, 2022, 185(3): 547-562.e22
3. Wen-Bing Jin; Chun-Jun Guo*; Boosting polyketides production in cell factories, Synthetic and Systems Biotechnology, 2020, 5(1): 35-36
4. Wen-Bing Jin; Sheng Wu; Yi-Fan Xu; Hua Yuan; Gong-Li Tang*; Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions, Natural Product Reports, 2020, 37: 17-28
5. Wen-Bing Jin#; Sheng Wu#; Xiao-Hong Jian; Hua Yuan*; Gong-Li Tang*; A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis, Nature Communications, 2018, 9(1): 2771
6. Wen-Bing Jin; Hua Yuan; Gong-Li Tang*; Strategies for Construction of Cyclopropanes in Natural Products, Chinese Journal of Organic Chemistry, 2018, 38(9): 2324
7. Clarissa Campbell; Peter T.McKenney; Daniel Konstantinovsky; Olga I.Isaeva; Michail Schizas; Jacob Verter; Cheryl Mai; Wen-Bing Jin; Chun-Jun Guo; Sara Violante; Ruben J.Ramos; Justin R.Cross; Krishna Kadaveru; John Hambor; Alexander Y.Rudensky*; Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells, Nature, 2020, 581(7809): 475-479
8. Mohammad Arifuzzaman; Tae Hyung Won; Ting-Ting Li; Hiroshi Yano; Sreehaas Digumarthi; Andrea F. Heras; Wen Zhang; Christopher N. Parkhurst; Sanchita Kashyap; Wen-Bing Jin; Gregory Garbès Putzel; Amy M. Tsou; Coco Chu; Qianru Wei; Alex Grier; Randy Longman; Gregory Sonnenberg; Ellen Scherl; Robbyn Sockolow; Dana Lukin; Robert Battat; Thomas Ciecierega; Aliza Solomon; Elaine Barfield; Kimberley Chien; Johanna Ferreira; Jasmin Williams; Shaira Khan; Peik Sean Chong; Samah Mozumder; Lance Chou; Wenqing Zhou; Anees Ahmed; Connie Zhong; Ann Joseph; Joseph Gladstone; Samantha Jensen; Stefan Worgall; Chun-Jun Guo; Frank C. Schroeder; David Artis*; Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation, Nature, 2022, 611(7936): 578-584
9. Wen Zhang; Mengze Lyu; Nicholas J. Bessman; Zili Xie; Mohammad Arifuzzaman; Hiroshi Yano; Christopher N. Parkhurst; Coco Chu; Lei Zhou; Gregory G. Putzel; Ting-Ting Li; Wen-Bing Jin; Jordan Zhou; Hongzhen Hu; Amy M. Tsou; Chun-Jun Guo; David Artis*; Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection, Cell, 2022, 185(22): 4170-4189.e20
10. Monica Viladomiu; Maeva L. Metz; Svetlana F. Lima; Wen-Bing Jin; Lance Chou; Chun-Jun Guo; Gretchen E. Diehl; Kenneth W. Simpson; Ellen J. Scherl; Randy S. Longman*; Adherent-invasive E. coli metabolism of propanediol in Crohn’s disease regulates phagocytes to drive intestinal inflammation, Cell Host & Microbe, 2021, 29(4): 607-619.e8

荣誉、奖励及参加学术团体的情况:

2019 Valedictorian, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2017 National Scholarship, Ministry of Education of the People’s Republic of China
2013 National Scholarship, Ministry of Education of the People’s Republic of China
2011-2013 1st Prize Scholarship x 3, Sun Yat-Sen University