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邮 箱:hecy@xmu.edu.cn
职称/职务:厦门大学生命科学学院教授、博士生导师
福建省高层次人才,厦门市留学回国人才
联系方式:
10篇代表性科研论文(#第一作者;*通讯作者):
1. Naying Zheng, Tingting Liao, Chuchu Zhang, Zheyang Zhang, Sen Yan, Xiaohan Xi, Fengkai Ruan, Chunyan Yang, Qingliang Zhao, Wenbo Deng, Jialiang Huang, Zi-Tao Huang, Zhi-Feng Chen, Xiang Wang, Qingming Qu, Zhenghong Zuo*, Chengyong He*. Quantum Dots-caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome. Advanced Science. 2024:e2406343.
2. Fengkai Ruan, Jie Zeng, Changqian Liu, Jianrong Han, Naying Zheng, Kun Li, Hanying Yin, Mingtao Wu, Xiaoyan Ding, Changshun Han, Dai Wang, Lingtao Yang, Chunyan Yang, Nengming Xiao, Zhenghong Zuo*, Chengyong He*. Gut microbiota dysbiosis mediates mouse kidney fibrosis induced by black phosphorus quantum dots. Nano Today. 2024;55:102203.
3. Chen Tang, Ying Zhang, Fucong Zhang, Yiwen Sun, Yue Zhu, Fanzheng Xue, Zhenhong Wang, You Wu, Jinpeng Ruan, Yiming Yue, Chunyan Yang, Wei Ge, Chengyong He*, and Zhenghong Zuo*. Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line. Environmental Health Perspectives. 2025.15372
4. Chengyong He#*, Fengkai Ruan#, Shengwei Jiang#, Jie Zeng, Hanying Yin, Rong Liu, Yongxing Zhang, Laiqiang Huang, Chonggang Wang, Shaohua Ma*, Zhenghong Zuo*. Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice and Human Cells. Small. 2020;2001371.
5. Haoxing Cai, Mingyue Chen, Yang Gao, Jinpeng Ruan, Chengyong He*, and Zhenghong Zuo*. Transgenerational Effects and Mechanisms of Tributyltin Exposure on Neurodevelopment in the Male Offspring of Rats. Environmental Science & Technology. 2023;57:10201-10210.
6. Jianrong Han#, Changqian Liu#, Zhiyuan Chen#, Fengkai Ruan, Fanzheng Xue, Lingxiao Ye, Yi Yu, Zhenghong Zuo*, Chengyong He*. Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention. Environment International. 2025;203:109780
7. Ruan#, Jie Zeng#, Hanying Yin#, Shengwei Jiang, Xisen Cao, Naying Zheng, Changshun Han, Chuchu Zhang, Zhenghong Zuo*, Chengyong He*. RNA m6A Modification Alteration by Black Phosphorus Quantum Dots Regulates Cell Ferroptosis: Implications for Nanotoxicological Assessment. Small Methods. 2021;5(3):e2001045.
8. Mingyue Chen#, Chengyong He#, Kongyang Zhu, Zihan Chen, Zixiao Meng, Xiaoming Jiang, Jiali Cai, Chunyan Yang, Zhenghong Zuo*. Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication. Theranostics. 2022;12(2):782-795. (Cover Story)
9. Xiaoyan Ding, Qin Yuan, Changshun Han, Chao Shen, Mingyue Chen, Hanying Yin, Hongbin Zhong, Chunyan Yang, Jiyi Huang*, Chengyong He*, Zhenghong Zuo*. Effects and mechanisms of theabrownin from black tea in improving hyperuricemia: Evidence from animal study and clinical trial. International Journal of Biological Macromolecules 2025;293:139373.
10. Fengkai Ruan, Rong Liu, Jie Zeng, Kai Wang, Zhenghong Zuo, Chengyong He*, Yongxing Zhang*. Cytotoxicity of black phosphorus quantum dots on lung-derived cells and the underlying mechanisms. Journal of Hazardous Materials. 2021;402:122875.
其他一作/通讯论文:
2025
11. You Gao, Changshun Han, Zhiyuan Chen, Jiancheng Huang, Tianyun Peng, Xiaoyan Ding, Hongbin Zhong, Lixin Liao, Chengyong He*, and Jiyi Huang*. Theabrownins improve burn- induced kidney injury by increasing the levels of guanidinoacetic acid and fumaric acid. Phytomedicine. 2025;140:156609.
12. Mingtao Wu, Jie Zeng, Wanru Huang, Fengkai Ruan, Zhenghong Zuo, Liang Bu*, Chengyong He*. Black phosphorus nanomaterials mediate size-dependent acute lung injury by promoting macrophage polarization. Food and Chemical Toxicology. 2025;196:115219.
13. Sihao Zhu, Fengkai Ruan, Lingxiao Ye, Suhua Jiang, Chunyang Yang, Zhenghong Zuo, Chengyong He*. Black phosphorus quantum dots induce lipid accumulation through PPARγ activation and mitochondrial dysfunction in adipocytes. Science of the Total Environment. 2025;958:177972.
14. Jianrong Han, Fengkai Ruan, Chunyan Yang, Zhenghong Zuo, Zonghong Liu*, Chengyong He*. Subacute exposure to black phosphorus quantum dots induces cardiac fibrosis and the potential role of gut microbiota. Journal of Environmental Sciences. 2025;152:167-177.
15. Weidong Zhou, Wenjing Zhang, Zhineng Fu, Chen Tang, Pengtao Chen, Ruofan Huang, Chunyan Yang, Shuzhen Chen, Zhenghong Zuo, Qionghua Chen*, Mingyue Chen*, Chengyong He*. Nano-sized titanium dioxide exposure induces non-hyperandrogenic polycystic ovarian syndrome in rats by increasing aromatase and apoptosis in granulosa cells. Journal of Environmental Sciences. 2025:156:632-646.
16. Fengkai Ruan, Longyang Li, Mingtao Wu, Fanzheng Xue, Zhineng Fu, Fucong Zhang, Zhenghong Zuo, Liang Bu*, Fanwei Zeng*, Chengyong He*. Fullerenol Doped Matrigel Promotes Maturation of Intestinal Organoids by Inhibiting Oxidative Stress and Apoptosis. ACS Applied Bio Materials. 2025;8(8):7161-7170.
17. Tingting Lin, Siyu Chen, Yingyi Ren, Junyu Liang, Zhenghong Zuo, Zhiqiang Luo, Jian Yang*, Chengyong He*. Developmental exposure to echimidine induces locomotor hyperactivity in zebrafish larvae via inhibiting acetylcholinesterase activity. Journal of Environmental Sciences. 2025;156:882-893.
2024
18. Fengkai Ruan, Changqian Liu, Jie Zeng, Fucong Zhang, Yu Jiang, Zhenghong Zuo, Chengyong He*. Multi-omics integration identifies ferroptosis involved in black phosphorus quantum dots-induced renal injury. Science of the Total Environment. 2024;947:174532.
19. Changqian Liu, Fengkai Ruan, Zhiyuan Chen, Jianrong Han, Xiaoyan Ding, Changshun Han, Lingxiao Ye, Chunyan Yang, Yi Yu, Zhenghong Zuo, Chengyong He*. Phenanthrene-induced hyperuricemia with intestinal barrier damage and the protective role of theabrownin: modulation by gut microbiota-mediated bile acid metabolism. Science of the Total Environment. 2024;949:174923.
20. Luanjin Wang, Cixin Liang, Naying Zheng, Chunyan Yang, Sen Yan, Xiang Wang, Zhenghong Zuo, Chengyong He*. Kidney injury contributes to edema of zebrafish larvae caused by quantum dots. Science of The Total Environment. 2024;908:168420.
21. Changshun Han#, Chengyong He#, Xiaoyan Ding, Zixuan Li, Tianyun Peng, Chensong Zhang, Haibing Chen, Zhenghong Zuo, Jiyi Huang*, and Weiping Hu*. WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway. Journal of Biological Chemistry. 2024;300(8):107485.
22. Shuo Huang, Jingyi Wang, Tingting Lin, Chengyong He*, Zhiyuan Chen*. Esketamine Exposure Impairs Cardiac Development and Function in Zebrafish Larvae. Toxics. 2024;12(6):427.
2023
23. Naying Zheng#, Xiaolian Sun#, Yiyue Shi#, Luheng Chen, Luanjin Wang, Haoxing Cai, Changshun Han, Tingting Liao, Chunyan Yang, Zhenghong Zuo, Chengyong He*. The valence state of iron-based nanomaterials determines the ferroptosis potential in a zebrafish model. Science of The Total Environment. 2023:855:158715.
24. Tingting Lin, Li Zhou, Zhibin Chen, Luanjin Wang, Jian Yang, Sheng Wang, Xintan Chen, Zhenghong Zuo, Chengyong He*, Lanping Guo*. Exposure to echimidine impairs the heart development and function of zebrafish larvae. Ecotoxicology and Environmental Safety. 2023;266:115574.
25. Meifang Wu#, Naying Zheng#, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He*. Icariin induces developmental toxicity via thyroid hormone disruption in zebrafish larvae. Food and Chemical Toxicology. 2023;182:114155.
26. Hanying Yin, You Gao, Weiguang Chen, Chen Tang, Zihan Zhu, Kun Li, Siyu Xia, Changshun Han, Xiaoyan Ding, Fengkai Ruan, Hanrui Tian, Changfeng Zhu, Suyuan Xie, Zhenghong Zuo, Lixin Liao*, Chengyong He*. Topically applied fullerenols protect against radiation dermatitis by scavenging reactive oxygen species. Discover Nano. 2023;18(1):101.
2022
27. Fengkai Ruan, Changqian Liu, Yi Wang, Xisen Cao, Zhen Tang, Jiaying Xu, Jie Zeng, Hanying Yin, Naying Zheng, Chunyan Yang, Zhenghong Zuo, Chengyong He*. Role of RNA m6A modification in titanium dioxide nanoparticle-induced acute pulmonary injury: An in vitro and in vivo study. Environmental Pollution. 2022;311:119986.
28. Jie Zeng, Fengkai Ruan, Mingtao Wu, Jiaying Xu, Zhenghong Zuo, Yi Yu*, Chengyong He*. Black phosphorus quantum dots cause glucose metabolism disorder and insulin resistance in mice. Ecotoxicology and Environmental Safety. 2022;246:114168.
29. Songwen Ren#, You Gao#, Luanjin Wang, Ce Qiu, Lingtao Yang, Li Li, Yueyue Xiao, Nengming Xiao, Lixin Liao, Zhenghong Zuo, Chunyan Yang*, Chengyong He*. Sacran polysaccharide improves atopic dermatitis through inhibiting Th2 type immune response. Life Sciences. 2022;288:120205.
30. Yi Wang, Fengkai Ruan, Zhenghong Zuo, Chengyong He*. Nanoparticle-Induced m6A RNA Modification: Detection Methods, Mechanisms and Applications. Nanomaterials. 2022;12(3): 389.
2021
31. Naying Zheng, Jinhui Yan, Wang Qian, Chao Song, Zhenghong Zuo, Chengyong He*. Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos. Journal of Environmental Sciences. 2021;100:240-249.
32. Junxia Shi, Chenyu Liu, Mingyue Chen, Jinhui Yan, Chonggang Wang, Zhenghong Zuo*, Chengyong He*. The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells. Environmental Toxicology. 2021;36(4):665-674.
33. Kongyang Zhu#, Chao Shen#, Chen Tang, Yixi Zhou, Chengyong He*, Zhenghong Zuo*. Improvement in the screening performance of potential aryl hydrocarbon receptor ligands by using supervised machine learning. Chemosphere. 2021;265:129099.
34. Yixi Zhou, Xue Han, Yuanyuan Bao, Zihan Zhu, Jiali Huang, Chunyan Yang, Chengyong He*, Zhenghong Zuo*. Chronic exposure to environmentally realistic levels of diuron impacts the behaviour of adult marine medaka (Oryzias melastigma). Aquatic Toxicology. 2021;238:105917.
2020
35. Chen Tang, Chao Shen, Kongyang Zhu, Yixi Zhou, Yung-Jen Chuang, Chengyong He*, Zhenghong Zuo*. Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae. Ecotoxicology and Environmental Safety. 2020;201:110808.
36. Jinhui Yan, Shujing Chen, Zhenghong Zuo, Chengyong He*, Muqing Yi*. Graphene oxide quantum dot exposure induces abnormalities in locomotor activities and mechanisms in zebrafish (Danio rerio). Journal of Applied Toxicology. 2020;40:794–803.
2019
37. Chuanli Yang, Peiyu Han, Fengkai Ruan, Tengjian Zhou, Bing Luo, Yang Qiu, Yuchun Lin, Zhongning Lin*, Chengyong He*. Lactational exposure to environmentally relevant benzo(a)pyrene causes astrocytic activation and anxiety-like behavior in male mice. Chemosphere. 2019;221: 67e74.
38. Zhibing Yang, Junxia Shi, Zhizhun Guo, Mingyue Chen, Chonggang Wang, Chengyong He*, Zhenghong Zuo*. A pilot study on polycystic ovarian syndrome caused by neonatal exposure to tributyltin and bisphenol A in rats. Chemosphere. 2019;231:151-160.
39. Chengyong He#, Shengwei Jiang#, Huan Yao#, Liyin Zhang, Chuanli Yang, Shan Jiang, Fengkai Ruan, Denglin Zhan, Gang Liu, Zhongning Lin*, Yuchun Lin*, Xiaoyuan Chen. High-content analysis for mitophagy response to nanoparticles: A potential sensitive biomarker for nanosafety assessment. Nanomedicine-Nanotechnology Biology and Medicine. 2019;15(1):59-69.
2018及以前
40. Shengwei Jiang#, Yuchun Lin#, Huan Yao#, Chuanli Yang, Liyin Zhang, Bing Luo, Zhao Lei, Liwei Cao, Naibo Lin, Xiangyang Liu*, Zhongning Lin*, Chengyong He*. The role of unfolded protein response and ER-phagy in quantum dots-induced nephrotoxicity: an in vitro and in vivo study. Archives of Toxicology. 2018;92(541):1-14.
41. Chengyong He#, Yang Qiu#, Peiyu Han#, Yuanyuan Chen, Liyin Zhang, Quan Yuan, Tianying Zhang, Tong Cheng, Lunzhi Yuan, Chenghao Huang, Sheng Zhang, Zhenyu Yin, Xian-E Peng, Dong Liang, Xu Lin, Yuchun Lin*, Zhongning Lin*, and Ningshao Xia. ER stress regulating protein phosphatase 2A-B56γ, targeted by hepatitis B virus X protein, induces cell cycle arrest and apoptosis of hepatocytes. Cell Death & Disease. 2018;9(7):762.
42. Chengyong He#, Shengwei Jiang#, Huan Yao#, Liyin Zhang, Chuanli Yang, Denglin Zhan, Gan Lin, Yun Zeng, Yankai Xia, Zhongning Lin*, Gang Liu*, Yuchun Lin*. Endoplasmic reticulum stress mediates inflammatory response triggered by ultra-small superparamagnetic iron oxide nanoparticles in hepatocytes. Nanotoxicology. 2018;12(10): 1198-1214.
43. Mei Chen#, Shuzhen Chen#, Chengyong He#, Shiguang Mo, Xiaoyong Wang, Gang Liu*, and Nanfeng Zheng*, Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging. Nano Research. 2017;10(4): 1234–1248.
44. Chengyong He#, Shengwei Jiang#, Haijing Jin#, Shuzhen Chen, Gan Lin, Huan Yao, Xiaoyong Wang, Peng Mi, Zhiliang Ji, Yuchun Lin*, Zhongning Lin*, Gang Liu*. Mitochondrial electron transport chain identified as a novel molecular target of SPIO nanoparticles mediated cancer-specific cytotoxicity. Biomaterials. 2016;83:102-114.
45. Bing Luo#, Yuchun Lin#, Shengwei Jiang, Lianyun Huang, Huan Yao, Qunying Zhuang, Ran Zhao, Hengchuan Liu, Chengyong He*, Zhongning Lin*. Endoplasmic reticulum stress eIF2α-ATF4 pathway-mediated cyclooxygenase-2 induction regulates cadmium-induced autophagy in kidney. Cell Death & Disease. 2016;7:e2251.
46. Chengyong He, Zhenghong Zuo, Xiao Shi, Lingbin Sun, Chonggang Wang*, Pyrene exposure influences the thyroid development of Sebastiscus marmoratus embryos. Aquatic Toxicology. 2012:124-125C;28-33.
47. Chengyong He, Chonggang Wang, Bowen Li, Meifang Wu, Hong Geng, Yixin Chen, Zhenghong Zuo*. Exposure of Sebastiscus marmoratus embryos to pyrene results in neurodevelopmental defects and disturbs related mechanisms. Aquatic Toxicology. 2012;116-117: 109-115.
48. Chengyong He, Zhenghong Zuo, Xiao Shi, Ruixia Li, Donglei Chen, Xin Huang, Yixin Chen, Chonggang Wang*. Effects of Benzo(a)Pyrene on the skeletal development of Sebastiscus marmoratus embryos and the molecular mechanism involved. Aquatic Toxicology. 2011;101:335–341.
49. Chengyong He, Chonggang Wang, Yulin Zhou, Jian Li, Zhenghong Zuo*. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus). Neurotoxicology. 2012; 33:758-762.
50. Chengyong He, Chonggang Wang, Bowen Li, Fazhi Xie, Yixin Chen, Zhenghong Zuo*. Tissue-specific and embryonic expression of the retinoid X receptors in Sebastiscus marmoratus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2009; 154(2):221-228.
1 |
2025年 |
中国毒理学优秀青年科技奖 |
2 |
2025年 |
厦门大学优秀共产党员 |
3 |
2021年 |
入选福建省高层次人才(C类) |
4 |
2024年 |
海南省自然科学奖二等奖(排名第3) |
5 |
2022年 |
第十五届福建省自然科学优秀学术论文二等奖(排名第1) |
6 |
2023年 |
指导本科生获得全国大学生生命科学竞赛(科学探究类)一等奖 |
7 |
2023年 |
第九届互联网+大学生创新创业大赛福建省赛铜奖 |
8 |
2022年 |
指导本科生获得全国大学生生命科学竞赛(创新创业类)一等奖 |
9 |
2022年 |
指导本科生获得全国大学生生命科学竞赛(科学探究类)一等奖 |
10 |
2022年 |
获得厦门大学生命科学学院科创指导奖 |
11 |
2022年 |
第八届互联网+大学生创新创业大赛福建省赛金奖、国赛铜奖 |
12 |
2022年 |
指导本科生获得全国大学生生命科学竞赛(创新创业类)三等奖 |
13 |
2022年 |
厦门大学首届实验教学比赛二等奖 |
14 |
2021年 |
全国高校生命科学类微课教学展示活动优秀微课三等奖 |
15 |
2021年 |
指导本科生获得全国大学生生命科学竞赛三等奖 |
16 |
2021年 |
获得厦门大学“科创竞赛”德贞优秀指导教师奖 |
17 |
2023年 |
The 1st International Conference on Eco-Environment & Health, Excellent Speaker |
18 |
2021年 |
获得中国毒理学会神经毒理专业委员会与表观遗传毒理专业委员会联合学术年会青年学者论坛优秀报告奖 |
19 |
2020年 |
指导本科生获得全国大学生生命科学竞赛二等奖 |
20 |
2020年 |
获得厦门大学清源奖教金 |
21 |
2018年 |
获得中共厦门大学公共卫生学院党委“优秀党务工作者”荣誉称号 |
22 |
2017年 |
获得四川美特生物奖教金 |
23 |
2016年 |
获得中国毒理学会第五次中青年学者科技论坛优秀论文奖 |
24 |
2015年 |
获得厦门大学养生堂奖教金 |
25 |
2018年至今 |
指导或协助指导研究生获得国家奖学金8人次 |