2003年，厦门大学生物科学专业，学士学位；
2009年，厦门大学细胞生物学专业，博士学位；
2005年，新加坡国立大学生物科学系，访问学生；
2009年至今，厦门大学生命科学学院，助理教授/副教授/教授。
B.S. 2003, Xiamen University, Biological Sciences;
Ph.D. 2009, Xiamen University, Cell Biology;
Visiting Students, Department of Biological Sciences, National University of Singapore, 2005;
Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University, 2009 to Present.

关注肿瘤细胞的代谢调控机制与细胞命运决定，重点探讨肿瘤细胞感应代谢应激到适应代谢应激的过程，分析核受体等关键节点蛋白在信号传递及微环境重塑过程中的作用。
The main interest of our lab is the understanding of metabolic regulation and cell fate determination of tumor cells, focusing on the process of sensing and adaptation of tumor cells to metabolic stress, and analyzing the role of nuclear receptor and other key node proteins in signal transduction and microenvironment remodeling.

代表性论文(^# co-first author, ^* Corresponding author):

1. Wu LZ^#, Mi XY^#, Liu ZJ^#, Ding Y^#, Hong WB^#, Cai CX, Hu HJ, Ai YL, Zhao BX, Qiu DD, Ma JS, Chen XQ, You Han, Lin T^*, Li FN^*, Hong XH^*, Chen HZ^*, Wu Q^*. Copper ion-induced MYH9 polymerization executes cuproptosis. Cell. 2026 Sep 14:S0092-8674(26)01003-2. DOI: 10.1016/j.cell.2026.08.030.
2. Chen XY^#, Xu KJ^#, Zhou JX^#, Wu LZ^#, Feng DY, Guan YF, Li HH, Yang GX, Qian Y, Mi MH, Wu SF, Zhang ZY, Chen QT, Zhou B, Chen HZ^*. The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation. Nature Cell Biology. 2026 Sep;28(9):1814-1829. DOI: 10.1038/s41556-026-02042-3.
3. Zhao J^#, Feng D^#, Zhang F^#, Cai S^#, Xiong Y, Pan G, Ma J, Tan J, Zhong M, Lin Z, Zhuang Y, Wang W, Zhou H, Zhou S, Cheng A, Xu M, Ye W, Chen HZ^*, Song Y^*, Wang Z^*, Hong X^*. Activated CD38+ mast cells promote gastric cancer progression by suppressing CD8+ T cell cytotoxic activity through adenosine metabolism. Cell Reports. 2026 Feb 24;45(2):116863. DOI: 10.1016/j.celrep.2025.116863.
4. Chen QT^#, Huang QL^#, Feng DY, Zhao WX, Zhang ZY, Jiang ZH, Han MZ, Chen SS, Zhang Y, Wu Q, Chen HZ^*. A unique intercellular feedforward loop from HK1 to TGF-β1 promotes the progression of hepatocellular carcinoma. Journal of Extracellular Vesicles. 2026; 15(3):e70255. DOI: 10.1002/jev2.7025.
5. Wu LZ^#, Huang YY^#, Hu HJ^#, Hong WB^#, Yan H^#, Ai YL, Mi XY, Feng DY, Guo JY, Ding Y, Liu ZJ, Zhou B, Xiao L, Lin T, Li FN^*, Chen XQ^*, Chen HZ^*, Wu Q^*. Disruption of heme homeostasis by nuclear receptor Nur77 induces pyroptosis through granzyme B-dependent GSDMC cleavage. Signal Transduction and Targeted Therapy. 2025 Dec 17;10(1):413. DOI: 10.1038/s41392-025-02528-w.
6. Chen QT^#, Huang QL^#, Han MZ^#, Hong XH^#, Feng DY, Yao LM, Hong WB, Chen Yue, Huang YY, Chen HZ^*, Wu Q^*. ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth. Advanced Science. 2026 Jan;13(4):e11683. DOI: 10.1002/advs.202511683.
7. Xiao L^#, Ai YL^#, Mi XY^#, Liang H^#, Zhi X^#, Wu LZ, Chen QT, Gou T, Chen C, Zhou B, Hong WB, Yao LM, Chen JJ, Deng X^*, Li FN^*, Wu Q^*, Chen HZ^*. cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models. Journal of Clinical Investigation. 2025 Jul 15;135(18):e188872. DOI: 10.1172/JCI188872.
8. Yang GX, Peng DL, Chen L, Qian Y, He L, Chen XY, Hong WB, Wu CM, Chen HZ^*. Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation. Cell Death Disease. 2025 16(1):595. DOI: 10.1038/s41419-025-07906-4.
9. Zhou B^#, Jiang ZH^#, Dai MR^#, Ai YL, Xiao L, Zhong CQ, Wu LZ, Chen QT, Chen HZ^*, Wu Q^*. Full-length GSDME mediates pyroptosis independent from cleavage. Nature Cell Biology. 2024 Sep;26(9):1545-1557. DOI: 10.1038/s41556-024-01463-2
10. Chen QT^#, Zhang ZY^#, Huang QL^#, Chen HZ^#*, Hong WB, Lin T, Zhao WX, Wang XM, Ju CY, Wu LZ, Huang YY, Hou PP, Wang WJ, Zhou D, Deng X, Wu Q^*. HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma. Nature Metabolism. 2022 Oct;4(10):1306-1321. DOI: 10.1038/s42255-022-00642-5.
11. Zhang JY^#, Zhou B^#, Sun RY^#, Ai YL^#, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ^*, Wu Q^*. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Research. 2021 Sep;31(9):980-997. DOI: 10.1038/s41422-021-00506-9.
12. Hou PP, Chen HZ^*. Extracellular vesicles in the tumor immune microenvironment. Cancer Letters. 2021 Sep 28; 516:48-56. DOI: 10.1016/j.canlet.2021.05.032.
13. Yang PB^#, Hou PP^#, Liu FY^#, Hong WB^#, Chen HZ^#, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T^*, Wu Q^*. Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proc Natl Acad Sci U S A. 2020 Nov 3; 117(44):27412-27422. DOI:10.1073/pnas.2002997117.
14. Hou PP^#, Luo LJ^#, Chen HZ^#, Chen QT^#, Bian XL^#, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q^*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. Molecular Cell. 2020 Jun 18; 78(6):1192-1206. DOI: 10.1016/j.molcel.2020.05.004.
15. Guan YF^#, Huang QL^#, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q, Chen HZ^*. Nur77-activated lncRNA WFDC21P Attenuates Hepatocarcinogenesis via Modulating Glycolysis. Oncogene. 2020 Mar, 39 (11), 2408-2423. DOI: 10.1038/s41388-020-1158-y.
16. Zhou B^#, Zhang JY^#, Liu XS^#, Chen HZ^#, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q^*. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Research. 2018 Dec; 28(12):1171-1185. DOI:10.1038/s41422-018-0090-y.
17. He JP^#, Hou PP^#, Chen QT^#, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ^*. Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression. Cancer Research. 2018, Sep 1; 78(17):4853-4864. DOI: 10.1158/0008-5472.CAN-17-3835.
18. Li XX^#, Wang ZJ^#, Zheng Y^#, Guan YF^#, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q^*, Chen HZ^*. Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation. Molecular Cell. 2018, 69(3):480-492. DOI: 10.1016/j.molcel.2018.01.001.
19. Bian XL^#, Chen HZ^#, Yang PB^#, Li YP^#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q^*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420. DOI: 10.1038/ncomms14420.
20. Li L^#, Liu Y^#, Chen HZ^#, Li FW^#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T^*, Wu Q^*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015, 11(5):339-46. DOI: 10.1038/nchembio.1788.
21. Wang WJ^#, Wang Y^#, Chen HZ^#, Xing YZ^#, Li FW^#, Zhang Q, Zhou B, Zhang HK, Zhang J, Bian XL, Li L, Liu Y, Zhao BX, Chen Y, Wu R, Li AZ, Yao LM, Chen P, Zhang Y, Tian XY, Beermann Friedrich, Wu M, Han J, Huang PQ, Lin T^*, Wu Q^*. Orphan nuclear receptor TR3 acts in autophagic cell death of melanoma via a mitochondrial signaling pathway. Nature Chemical Biology. 2014, 10:133-140. DOI: 10.1038/nchembio.1406.

荣誉、奖励及参加学术团体的情况:

福建省自然科学奖一等奖（第2完成人），2025年;
福建省自然科学奖一等奖（第3完成人)，2018年；
福建省自然科学奖一等奖（第2完成人），2013年；
福建省青年拔尖创新人才，2014年。