1995年，兰州医学院（现兰州大学医学院）临床医学专业，学士学位；
1998年，兰州医学院（现兰州大学医学院）临床血液学，硕士学位；
2001年，兰州大学无机化学，理学博士；
2003-2005年，香港科技大学，访问学者；
2010-2011年，多伦多大学，博士后；
2001年至今，厦门大学生命科学学院，助理教授/副教授/教授；
2017年至今，厦门大学生命科学学院，副院长。
B.S. 1995, Lanzhou Medical College, Clinical Medicine;
M.S. 1998, Lanzhou Medical College, Clinical Hematology;
Ph.D. 2001, Lanzhou University, Inorganic Chemistry;
Visiting Scholar, Hongkong University of Science and Technology, 2003-2005;
Postdoc Fellow, University of Toronto, 2010-2011;
Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University, 2001 to Present;
Vice Dean, School of Life Sciences, Xiamen University, 2017 to Present.

研究结肠癌、肝癌、胰腺癌、胶质瘤及乳腺癌等肿瘤代谢重编程的特点及分子机理，揭示代谢重编程对肿瘤生长、增殖、死亡及免疫逃逸等的调控作用。鉴定基于异常代谢的肿瘤诊断标志物和治疗靶点，并与企业合作开发相应的肿瘤诊疗方法和产品。近期研究方向包括：
1. Pirin蛋白促进肿瘤免疫逃逸的机理及以其为靶点的免疫治疗策略研究。
2. IDH1/2突变肿瘤新治疗靶点的鉴定及治疗策略研究。
3. GLS1结构重塑的机理及针对GLS1的抗肿瘤药物研究。
4. 原癌基因c-src通过改变细胞代谢模式促进肿瘤发生和转移的分子机制。
5. 乙酸代谢在肿瘤、糖尿病及心血管等代谢性疾病中的作用及机理。

To investigate the features and molecular mechanisms underlying the metabolic reprogramming of tumors such as colorectal cancer, liver cancer, pancreatic cancer, glioma and breast cancer, uncover the regulatory roles of metabolic reprogramming in the growth, proliferation, death, and immune evasion of these tumors, identify tumor diagnostic biomarkers and therapeutic targets based on abnormal metabolism, and eventually collaborate with enterprises to develop corresponding novel methods and products for tumor diagnosis and treatment. Detailed research interests are as follows.
1. Mechanism of Pirin Protein in Promoting Tumor Immune Evasion and Immunotherapy Strategies with Pirin as a Target.
2. Identification of Novel Therapeutic Targets and Development of Treatment Strategies against IDH1/2 Mutant Tumors.
3. Mechanism of GLS1 Structural Remodeling and Development of Antitumor Drugs Targeting GLS1.
4. The Roles of Metabolic Alterations Caused by Proto-oncogene c-Src in Tumorigenesis and Metastasis.
5. The Roles and Molecular Mechanisms of Acetate Metabolism in Metabolic Diseases Including Tumor, Diabetes Mellitus and Cardiovascular Diseases.

代表性论文(^# co-first author, ^* Corresponding author):

1. Zhao W^#, Ouyang C^#, Zhang L^#, Wang J^#, Zhang J^#, Zhang Y, Huang C, Xiao Q, Jiang B, Lin F, Zhang C, Zhu M, Xie C, Huang X, Zhang B, Zhao W, He J, Chen S, Liu X, Lin D, Li Q^*, Wang Z^*. The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis. Nat Commun. 2024 Aug 28;15(1):7455.
2. Ma H^#, Suleman M^#, Zhang F^#, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B^*, Li Q^*. Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival. Adv Sci (Weinh) . 2024 Mar; 11(10): e2301476.
3. Wang J^#, Wen Y^#, Zhao W^#, Zhang Y, Lin F, Ouyang C, Wang H, Yao L, Ma H, Zhuo Y, Huang H, Shi X, Feng L, Lin D^*, Jiang B^*, Li Q^*. Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress. Elife. 2023 Oct 30; 12: RP87419.
4. Zhao W^#, Ouyang C^#, Huang C, Zhang J, Xiao Q, Zhang F, Wang H, Lin F, Wang J, Wang Z^*, Jiang B^*, Li Q^*. ELP3 stabilizes c-myc to promote tumorigenesis. J Mol Cell Biol. 2023 Sep 28: mjad059.
5. Wang H^#, Lin F^#, Xu Z^#, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B^*, Li Q^*. ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC. Cell Mol Gastroenterol Hepatol. 2023 Jun 17; 16(4): 541-556.
6. Jiang B^#, Zhang J^#, Zhao G^#, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q^*. Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. Molecular Cell 2022 May 19; 82(10):1821-1835.e6. doi: 10.1016/j.molcel.2022.03.016
7. Zhou Y^#, Lin F^#, Wan T^#, Chen Ai^#, Wang H, Jiang B, Zhao W, Liao S, Wang S, Li G, Xu Z, Wang J, Zhang J, Ma H, Lin D, Li Q^*. ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM. Theranostics 2021 April 03; 11(12):5926-5938.
8. Ma H^#, Zhang F^#, Zhou L, Cao T, Sun D, Wen S, Zhu J, Xiong Z, Tsau M-T, Cheng M-L, Hung L-M, Zhou Y, Li Q^*. c-Src facilitates tumorigenesis by phosphorylating and activating G6PD. Oncogene 2021 March 08; 40:2567–2580.
9. Ma H^#, Zhang J, Zhou L, Wen S, Tang HY, Jiang B, Zhang F, Suleman M, Sun D, Chen A, Zhao W, Lin F, Tsau MT, Shih LM, Xie C, Li X, Lin D, Hung LM^*, Cheng ML^*, Li Q^*. c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3. Cell Rep. 2020 Mar 24; 30(12):4235-4249.e6.
10. Suleman M^#, Chen A^#, Ma H^#, Wen S, Zhao W, Lin D, Wu G^*, Li Q^*. PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1. Cell Cycle. 2019 Nov; 18(21):2914-2927.
11. Jiang B^#, Zhao W^#, Shi M^#, Zhang J, Chen A, Ma H, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, Liu M, Wen S, Ouyang C, Wang H, Huang X^*, Zhou H^*, Li Q^*. IDH1 R132 mutant promotes tumor formation through downregulating p53. J. Biol. Chem. 2018 Jun 22; 293(25):9747-9758
12. Yang Z^#, Jiang B^#, Wang Y^#, Ni H, Zhang J, Xia J, Shi M, Hung L-M, Ruan J, Mak TW, Li Q^* and Han J^*. 2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter. Cell Reports. 2017 May 30; 19(9): 1846-1857.
13. Jiang B^#, Zhang J^#, Xia J^#, Zhao W, Wu Y, Shi M, Luo L, Zhou H, Chen A, Ma H, Zhao Q, Suleman M, Lin F, Zhou L, Wang J, Zhang Y, He Y, Li X, Hung LM, Mak TW, Li Q^*. IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell Reports. 2017 Apr 11; 19(2): 389-400.
14. Zhang J^#, Wang S^#, Jiang B^#, Huang L, Ji Z, Li X, Zhou H, Han A, Chen A, Wu Y, Ma H, Zhao W, Zhao Q, Xie C, Sun X, Zhou Y, Huang H, Suleman M, Lin F, Zhou L, Tian F, Jin M, Cai Y, Zhang N, Li Q^*. c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis. Nature Communications. 2017 Jan 5; 8:13732.
15. Liu Q, Cheng Z, Luo L, Yang Y, Zhang Z, Ma H, Chen T, Huang X, Lin S-Y, Jin M, Li Q^*, Li X^*. C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis. Oncotarget. 14; 7(24): 36800-36813. 2016, May 5.
16. Xu M^#, Cai C^#, Sun X, Chen W, Li Q^*, Zhou H^*. Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line. Biochem Biophys Res Commun. 463(3): 275-9. 2015, Jul 31.
17. Ying He^#, Guili Lian^#, Shuyong Lin, Zhiyun Ye, Qinxi Li^*. MDM2 Inhibits Axin-induced p53 Activation Independently of Its E3 Ligase Activity. PLOS ONE, 8(6): e67529. 2013, Jun 27.
18. Lin SY^#, Li TY^#, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC^*. GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 336(6080): 477-81, 2012, Apr 27.
19. Li Q^#, He Y^#, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC^*., AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation. Oncogene. 30(10): 1194-1204, 2011.
20. Li Q^#, Lin S^#, Wang X^#, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J and Lin S-C, Axin determines cell fates by controlling p53 activation threshold upon DNA damage. Nature Cell Biology. 11(9): 1128-1134, 2009.
21. Li Q^#*, Ye Z^#, Wen J, Ma L, He Y, Lian G, Wang Z, Wei L, Wu D and Jiang B, Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells. Biochem. Biophys. Res. Commun. 385(2): 284-289, 2009.
22. Li Q^#, Zhang N^#, Zhang D, Wang Y, Lin T, Wang Y, Zhou H, Ye Z, Zhang F, Lin SC. and Han J^*, Determinants that control the distinct subcellular localization of p38α-PRAK and p38β-PRAK complexes. J. Biol. Chem. 283(16): 11014-23, 2008
23. Li Q, Wang X, Wu X, Rui Y, Liu W, Wang J, Wang X, Liou Y-C, Ye Z and Lin SC^*, Daxx Cooperates with the Axin/HIPK2/p53 Complex to Induce Cell Death. Cancer Res. 67(1): 66-74, 2007
24. Zou, H., Li, Q.^*, Lin, S.C., Wu, Z., Han, J. and Ye, Z.^*, Differential requirement of MKK4 and MKK7 in JNK activation by distinct scaffold proteins. FEBS Letters 581(2): 196–202, 2007.
25. Li J, Li Q^*, Xie C, Zhou H, Wang Y, Zhang N, Shao H, Chan SC, Peng X, Lin SC and Han J^*, beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death. Journal of Cell Science 117: 4673-4680, 2004.

获批发明专利
1. PFKFB3蛋白的第194位酪氨酸的磷酸化及其应用， 201710451646.5，厦门大学，2021年6月28日.

荣誉、奖励及参加学术团体的情况:

“第四届复旦大学谈家桢基金生命科学九源奖学金”二等奖，2000年
教育部“新世纪优秀人才支持计划”入选者，2009年
福建省自然科学基金杰出青年基金获得者，2009年
福建省高等教育教学成果奖特等奖，2017年
国家高等教育教学成果奖二等奖，2018年
“宝钢优秀教师奖”，2019年
福建省高等教育教学成果奖特等奖，2020年
教育部生物科学类专业教学指导委员会委员，2018-2022年
国家高等教育教学成果奖二等奖，2023年