2003年，厦门大学生物科学专业，学士学位；
2006年，香港科技大学生物化学专业，博士学位；
2009年，厦门大学生物化学与分子生物学，博士学位；
2009年至今，厦门大学生命科学学院，助理教授/副教授/教授；
B.S. 2003, Xiamen University, Biological Sciences;
Ph.D. 2006, Hong Kong University of Science and Technology, Biochemistry;
Ph.D. 2009, Xiamen University, Biochemistry and Molecular Biology;
Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University, 2009 to Present.

研究聚焦于营养感应关键蛋白质及信号通路在生理与病理状态下的调控机制。在基础研究领域取得系列创新发现：首次揭示生长因子缺乏诱导的细胞自噬信号转导途径，阐明自噬关键蛋白在药物性肝损伤中的分子机制；发现AIDA蛋白在哺乳动物中的首个生理功能——通过内质网相关蛋白质降解途径调控肠道脂肪合成酶降解，抑制脂质吸收与肥胖发生；揭示冷刺激下AIDA蛋白响应肾上腺能信号转位至线粒体，通过直接结合UCP1增强其氧化修饰与产热活性的体温调节新机制。基于上述发现，当前研究拓展至宿主-肠道菌群互作领域，重点探索宿主遗传背景与药物干预通过调控菌群影响代谢稳态、认知功能及神经炎症的分子网络。
My research focuses on the regulatory mechanisms of nutrient-sensing proteins and signaling pathways in physiological and pathological conditions. Key discoveries include: 1) Pioneering elucidation of autophagy signaling pathways induced by growth factor deprivation, revealing molecular mechanisms of core autophagy proteins in drug-induced liver injury; 2) Identification of the first physiological function of AIDA in mammals - mediating degradation of lipogenic enzymes via ER-associated degradation (ERAD) pathway in intestine to suppress fat absorption and obesity; 3) Discovery of cold-induced AIDA translocation to mitochondrial intermembrane space through adrenergic signaling, where it directly binds UCP1 to enhance oxidative modification and thermogenic activity. Building upon these findings, current investigations extend to host-microbiota interactions, particularly exploring how host genetic factors and pharmacological interventions modulate gut microbiota to influence metabolic homeostasis, cognitive function, and neuroinflammatory processes.

代表性论文(^# co-first author, ^* Corresponding author):

1. Wu WJ^#, Wang J^#, Chen F, Wang X, Lan B, Fu R, Wen H, Chen F, Hong W, Tang TY, He Y, Chen G, Zhou J, Piao HL^*, Chen D^*, Lin SY^*. Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma. Molecular Oncology. 2025 Feb 28. doi: 10.1002/1878-0261.70012
2. Liu C^#, Lin Y^#, Wang Y^#, Lin S^#, Zhou J, Tang H, Yi X, Ma Z, Xia T, Jiang B, Tian F, Ju Z, Liu B, Gu X^*, Yang Z^*, Wang W^*. HuR promotes triglyceride synthesis and intestinal fat absorption. Cell Reports 2024 43: 114238.
3. Wu HM ^#, Yang YV^#, Huang NJ, Fan LP, Dai YY, Hu KT, Tang TY, Liu L, Xu Y, Liu DT, Cai ZX, Niu XY, Ren XY, Yao ZH, Qin HY, Chen JZ, Huang X, Zhang C, You X, Wang C, He Y, Hong W, Sun YX, Zhan YH^*, Lin SY^*. Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance. Frontiers in Neuroscience 2024 18: 1368552. doi: 10.3389/fnins.2024.1368552
4. Shi M^#, Huang XY^#, Ren XY, Wei XY, Ma Y, Lin ZZ, Liu DT, Song L, Zhao TJ, Li G, Yao L, Zhu M, Zhang C, Xie C, Wu Y, Wu HM, Fan LP, Ou J, Zhan YH, Lin SY^*, Lin SC^*. AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1. Nature Cell Biology 2021 23: 268-277. doi: 10.1038/s41556-021-00642-9
5. Lin SY^*, Lin SC. SRC promotes lipogenesis: implications for obesity and breast cancer. Molecular & Cellular Oncology 2021 8: 1866975. doi: 10.1080/23723556.2020.1866975
6. Song L^#, Liu Z^#, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Chen L, Song E, Lin SY, Lin SC^*. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. Nature Communications 2020 11: 5842.
7. Lin SY, Zhang CS, Lin SC^*. Carbohydrates: Not All that Bad? Cell Metabolism 2018 28: 671-672. DOI: 10.1016/j.cmet.2018.10.004
8. Li TY^#, Song L^#, Sun Y^#, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC^*. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nature Communications 2018 9: 1916.
9. Luo H^#, Jiang M^#, Lian G, Liu Q, Shi M, Li TY, Song L, Ye J, He Y, Yao L, Zhang C, Lin ZZ, Zhang CS, Zhao TJ, Jia WP, Li P, Lin SY^*, Lin SC^*. AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity. Cell Metabolism 2018 27: 843-853. doi: 10.1016/j.cmet.2018.02.021
10. Sun Y^#, Li TY^#, Song L^#, Zhang C, Li J, Lin ZZ, Lin SC, Lin SY^*. Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury. Hepatology 2018 67: 2397-2413. doi: 10.1002/hep.29759
11. Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC^*. ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy. Molecular Cell 2016 62: 359-370.
12. Zheng LS^#, Liu YT^#, Chen L, Wang Y, Rui YN, Huang HZ, Lin SY, Wang J, Wang ZX, Lin SC, Wu JW^*. Structure and mechanism of the unique C2 domain of Aida. FEBS J. 2014 281: 4622-4632.
13. Li TY, Lin SY, Lin SC^*. Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda) 2013 28: 423-431.
14. Ruan K^#, Ye F^#, Li C^#, Liou YC, Lin SC, Lin SY^*. PLK1 Interacts and Phosphorylates Axin That Is Essential for Proper Centrosome Formation. PLoS One 2012 7: e49184. DOI: 10.1371/journal.pone.0049184
15. Lin SY^#, Li TY^#, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC^*. Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy. Autophagy 2012 8: 1385-1386. doi: 10.4161/auto.20959
16. Lin SY^#, Li TY^#, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC^*. GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy. Science 2012 336: 477-481. doi: 10.1126/science.1217032
17. Li Q^#, Lin S^#, Wang X^#, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC^*. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology 2009 11: 1128-1134. doi: 10.1038/ncb1927
18. Lin S^#, Wang J, Ye Z, Ip NY, Lin SC^*. CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5. FEBS Letters 2008 582: 1197-1202. doi: 10.1016/j.febslet.2008.02.053
19. Rui Y^#, Xu Z^#, Xiong B^#, Cao Y^#, Lin S, Zhang M, Chan SC, Luo W, Han Y, Lu Z, Ye Z, Zhou HM, Han J, Meng A^*, Lin SC^*. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Developmental Cell 2007 13: 268-282.
20. Rui Y^#, Xu Z^#, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC^*. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. EMBO Journal 2004 23: 4583-4594.

荣誉、奖励及参加学术团体的情况:

福建省特殊支持人才“双百计划”青年拔尖创新人才（Youth Top-notch Talent in Fujian province），2016年
国家优秀青年科学基金资助（Outstanding Youth Science Foundation），2018年
福建省自然科学奖一等奖（Fujian Natural Science Award），2019年