1991年,上海水产大学食品工程专业,学士学位;
1998年,日本长崎大学海洋食品科学专业,硕士学位;
2001年,日本长崎大学海洋科学专业,博士学位;
2002-2004年,厦门大学生命科学学院,博士后;
2006年,厦门大学生命科学学院,副教授。
B.S. 1991, Shanghai Fisheries University, Food engineering;
M.S. 1998, Nagasaki University, Marine food science;
Ph.D. 2001, Nagasaki University, Marine science;
Postdoctoral Fellow, Xiamen University, 2002-2004;
Associate Professor, School of Life Sciences, Xiamen University, 2006 to Present.
酪氨酸酶(黑色素形成的关键酶)抑制剂的筛选、对酶的抑制作用机理、对黑色素形成的调控机制及其在美白化妆品及果蔬保鲜中的应用;出生前补充茶多酚(EGCG)对成年小鼠健康的影响。
Our research focuses on: 1) Screening of inhibitors of tyrosinase (the key enzyme of melanin formation), the mechanism of inhibiting the enzyme, the regulation mechanism of melanin formation and its application in whitening cosmetics and fruit and vegetable preservation; 2) Effects of prenatal tea polyphenols (EGCG) supplementation on health of adult mice.
代表性论文(# co-first author, * Corresponding author):
1. Wu W, Wu MY, Dai T, Ke LN, Shi Y, Hu J*, Wang Q*. Terphenyllin induces CASP3-dependent apoptosis and pyroptosis in A375 cells through upregulation of p53. Cell Communication and Signaling. 2024; 22: 409.
2. Hu JJ#, Chen B#, Qu SJ, Liu SJ, Yang XY, Qiao K, Su YC, Liu ZH, Chen XE*, Liu ZY*, Wang Q*. Anti-Melanogenic Effects of Takifugu flavidus Muscle Hydrolysate in B16F10 Melanoma Cells and Zebrafish. Marine Drugs. 2024; 22, 206.
3. Ou KL#, Zhang Q#, Xi FF, Ni HZ, Lu JB, Lyu XJ, Wang CG, Li QY*, Wang Q*. Prenatal EGCG consumption impacts hepatic glycogen synthesis and lipid metabolism in adult mice. International Journal of Biological Macromolecules. 2024; 260: 129491.
4. Xia SY, Xi FF, Ou KL, Zhang Y, Ni HZ, Wang CG, Wang Q∗. The effects of EGCG supplementation on pancreatic islet α and β cells distribution in adult male mice. Journal of Nutritional Biochemistry. 2024; 124: 109529.
5. Wu YL, Liu GS, Li ZP*, Chen ML*, Wang Q*. ATG13 is involved in immune response of pathogen invasion in blood clam Tegillarca granosa. Frontiers in Veterinary Science. 2023; 10: 1141284.
6. Ou KL#, Zhang SL#, Song JL, Fang L, Xia SY, Huang J, Wang Q*, Wang CG*. Prenatal EGCG consumption causes obesity and perturbs glucose homeostasis in adult mice. Journal of Nutritional Biochemistry. 2022; 111, 109179.
7. Xia SY#, Ou KL#, Zhang SL, Huang J, Fang L, Wang CG, Wang Q*. EGCG exposure during pregnancy affects uterine histomorphology in F1 female mice and the underlying mechanisms. Food and Chemical Toxicology. 2022; 167, 11330.
8. Chen B#, Yu L#, Wu JN, Qiao K, Cui LL, Qu HD, Su YC, Cai SL, Liu ZY*, Wang Q*. Effects of Collagen Hydrolysate from Large Hybrid Sturgeon on Mitigating Ultraviolet B-Induced Photodamage. Frontiers in Bioengineering and Biotechnology. 2022; 10: 908033.
9. Liu TT, Liu XT, Huang GL, Liu L, Chen QX, Wang Q*. Theophylline Extracted from Fu Brick Tea Affects the Metabolism of Preadipocytes and Body Fat in Mice as a Pancreatic Lipase Inhibitor. International Journal of Molecular Sciences. 2022; 23(5): 2525.
10. Chen B#, Chen HH#, Qu HD, Qiao K, Xu M, Wu JN, Su YC, Shi Y, Liu ZY*, Wang Q*. Photoprotective effects of Sargassum thunbergii on ultraviolet B-induced mouse L929 fibroblasts and zebrafish. BMC Complementary Medicine and Therapies. 2022, 22:144.
11. Feng HM, Qiao K, Wang CC, Chen B, Xu M, Hao H, Huang Z, Liu ZY*, Wang Q*. Multi-Omics Analysis of Gene and Protein Candidates Possibly Related to Tetrodotoxin Accumulation in the Skin of Takifugu flavidus. Marine Drugs. 2021; 19: 639-658.
12. Zhang SL#, Ou KL#, Huang J, Fang L, Wang CG, Wang Q*. Prenatal EGCG exposure-induced heart mass reduction in adult male mice and underlying mechanisms. Food and Chemical Toxicology. 2021; 157: 112588.
13. Hu YH, Zhou Y, Hu XH, Chen QL, Shi Y, Zhuang JX*, Wang Q*. Cefotaxime sodium inhibited melanogenesis in B16F10 cells by cAMP/PKA/CREB pathways. Process Biochemistry. 2021; 110: 63-70.
14. Liu XT#, Liu TT#, Xu HL, Chen QX*, Wang Q*. Inhibitory kinetics and bioactivities of Nuciferine and Methyl Ganoderate on Mucor miehei lipase and 3T3-L1 preadipocytes. International Journal of Biological Macromolecules. 2020; 163: 1719-1728.
15. Chen YM, Li C, Zhang WJ, Shi Y, Wen ZJ, Chen QX, Wang Qin*. Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents. Journal of Enzyme Inhibition and Medicinal Chemistry. 2019; 34(1): 990-998.
16. Chen YM#, Su WC#, Li C, Shi Y, Chen QX, Zheng J, Tang DL, Chen SM, Wang Q*. Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish. International Journal of Biological Macromolecules. 2019; 123: 723-731.
17. Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q*, Shen DY*. Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway. Oncology Reports. 2019, 41: 213-223.
荣誉、奖励及参加学术团体的情况:
福建省新世纪人才,2008年
福建省科学技术进步奖三等奖,2010年,2022年
厦门市科学技术进步奖二等奖,2014年
高等教育国家级教学成果奖二等奖,2018年
第三届全国大学生生命科学创新创业大赛(创业类)三等奖,2018年,指导教师
第三届全国大学生生命科学竞赛(科学探究类)一等奖,2019年,指导教师
第四届全国大学生生命科学创新创业大赛(创新类)三等奖,2019年,指导教师
第八届全国大学生生命科学竞赛(科学探究类)二等奖,2023年,指导教师