2009-2014年，北京大学基础医学专业，学士学位；
2014-2017年，北京大学生物物理学专业，博士学位；
2017-2020年，北京大学基础医学院，博士后；
2020年至今，厦门大学生命科学学院，助理教授；
B.S. 2009-2014, School of Basic Medical Sciences, Peking University;
Ph.D. 2014-2017, School of Basic Medical Sciences, Peking University;
Postdoctoral Fellow 2017-2020, School of Basic Medical Sciences, Peking University;
Assistant Professor 2020 - present, School of Life Sciences, Xiamen University;

原核生物的免疫系统包括有CRISPR-Cas系统、限制性修饰系统、噬菌体排斥系统、噬菌体信号系统、核酸解旋酶系统、毒素-抗毒素系统以及原核Argonautes系统。核酸酶以及核酸修饰相关蛋白也是上述多种免疫系统发挥作用的关键分子机器。同时，随着微生物基因组数据库的不断扩容，挖掘原核生物中存在的新型防御系统成为可能。我们重点聚焦原核生物中新型防御系统的抗病毒机制研究，通过机制研究，挖掘出具有潜在应用价值和优越前景的核酸酶应用工具，进而开发出完全具有我国自主知识产权的新型基因操纵工具和体外诊断技术

代表性论文(^# co-first author, ^* Corresponding author):

1. Chen J^#*, Lin X^#, Xiang W, Chen Y, Zhao Y, Huang L, Liu L^*. DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems. Nucleic Acids Research. 2024 Dec 16:gkae1241. doi: 10.1093/nar/gkae1241.
2. Chen J^#, Chen Y^#, Huang L^#, Lin X, Chen H, Xiang W, Liang Liu^*. Trans-nuclease activity of Cas9 activated by DNA or RNA target binding. Nature Biotechnology. 2024; doi: 10.1038/s41587-024-02255-7.
3. Chen J^#, Chen H^#, Li S^#, Lin X, Hu R, Zhang K^*, Liu L^*. Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery. eLife. 2024; 12:RP86847.
4. Chen J^#, Hu R^#, Chen Y^#, Lin X^#, Xiang W, Chen H, Yao C, Liu L^*. Structural basis for MTA1c-mediated DNA N6-adenine methylation. Nature Communications. 2022; 13(1):3257.
5. Wang J^#, Chen J^#, Wu G^#, Zhang H^#, Du X^#, Chen S, Zhang L, Wang K, Wu X, Gao S, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y^*, Li J^*, Yun C^*, Cheng H^*. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes & Development. 2019 May 1;33(9-10):536-549.
6. Chen J, Liu L, Cao C, Li M, Tan K, Yang X, Yun C^*. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Scientific Reports. 2016 Aug 23:6:31425.
7. Liu L^#, Chen J^#, Yang B, Wang F, Wang Y^*, Yun C^*. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function. Structure. 2015 Nov 3;23(11):2066-75.
8. Zhao P, Yao M, Zhu S, Chen J, Yun C^*. Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem Biophys Res Commun. 2018 Jul 20;502(3):332-337.
9. Shi Y, Fan S, Wang D, Huyan T, Chen J, Chen J, Su J, Li X, Wang Z, Xie S, Yun C, Li X, Tie L^*. FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission. Biochim Biophys Acta. 2018 Jul;1864(7):2481-2494.
10. Liu F^#, Wang B^#, Wang Q^#, Qi Z^#, Chen C^#, Kong L^#, Chen J, Liu X, Wang A, Hu C, Wang W, Wang H, Wu F, Ruan Y, Qi S, Liu J, Zou F, Hu Z, Wang W, Wang L, Zhang S, Yun C^*, Zhai Z^*, Liu J^*, Liu Q^*. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget. 2016 Jul 19;7(29):45562-45574.
11. Liu L, Chen J, Yang B, Wang Y^*. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem Biophys Res Commun. 2015 Mar 6;458(2):429-34.
12. Liu L, Chen J, Yang B, Wang Y^*. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions. FEBS Open Bio. 2015 Mar 5:5:155-62.

荣誉、奖励及参加学术团体的情况:

北京大学优秀毕业生，2017年