2013年，福建医科大学药学专业，学士学位；
2016年，福建医科大学生物信息专业，硕士学位；
2019年，清华大学生物信息专业，博士学位；
2019年，厦门大学生命科学学院，助理教授；
2026年，厦门大学生命科学学院，副教授。
B.S. Pharmacy, Fujian Medical University, 2013
M.S. Bioinformatics, Fujian Medical University, 2016
Ph.D. Bioinformatics, Tsinghua University, 2019
Assistant Professor, School of Life Sciences, Xiamen University, 2019
Associate Professor, School of Life Sciences, Xiamen University, 2026

主要从事生物信息学与精准肿瘤学研究，具体内容如下:
(1)肿瘤微环境临床表型智能解析与标志物鉴定(诊断，预后与药效预测)
(2)基于质谱技术的免疫肽组智能解析与肿瘤新抗原识别
(3)人工智能驱动的抗体序列解析与药物靶标发现
(1) Intelligent Analysis of clinical phenotype for tumor microenvironment and Identification of Biomarkers (Diagnosis, Prognosis, and Therapeutic Response Prediction)
(2) Mass Spectrometry-Based immunopeptidomes Mining and Tumor neo-antigen recognition
(3) Antibody sequence analysis and drug target discovery driven by artificial intelligence

代表性论文(^# co-first author, ^* Corresponding author):

1.Yuxiang Lin^#, Zening Huang^#, Ziyan Lin^#, Yating Lin^#, Ling Luo, Jinsheng Song, Youxin Gao, Junjie Lin, Xinyu Li, Chenyu Liang, Lei Zhang, Xinkang Wang, Xushi Zhang, Yufan Liao, Yuqin Sun^*, Rongshan Yu^*, Qiyue Chen^*, and Mengsha Tong^*. TiRank prioritizes phenotypic niches in tumor microenvironment for clinical biomarker discovery. Genome Medicine.2026 Feb 13;18(1):23.
2.Jiajing Xie^#, Tongxu Qi^#, Ying Chen, Chaoyong Yang, Mengsha Tong^*, Rongshan Yu^*. Protocol to predict the origin of cancer of unknown primary from gene expression data using BPformer. STAR Protocols. 2025 Oct 1;6(4):103881.
3.Zheyang Zhang^#, Ronghan Tang^#, Ming Zhu^#, Zhijuan Zhu, Jiali Zhu, Hua Li, Mengsha Tong^*, Nainong Li^*, Jialiang Huang^*. Deciphering cell states and the cellular ecosystem to improve risk stratification in acute myeloid leukemia. Briefings in Bioinformatics, 2025, 26(1), bbaf028
4.Jiajing Xie^#, Yuhang Song^#, Hailong Zheng, Shijie Luo, Ying Chen, Chen Zhang, Rongshan Yu^*, Mengsha Tong^*. PathMethy: an interpretable AI framework for cancer origin tracing based on DNA methylation. Briefings in Bioinformatics, 2024 Sep 23; 25(6):bbae497.
5.Yachen Liu, Longfei Mei, Chenyu Liang, Chuan-Qi Zhong, Mengsha Tong^*, Rongshan Yu^*.Cross-Run Hybrid Features Improve the Identification of Data Independent Acquisition Proteomics. ACS Omega 2024, 9, 46362−46372.
6. Mengsha Tong^#*, Yuxiang Lin^#, Wenxian Yang, Jinsheng Song, Zheyang Zhang, Jiajing Xie, Jingyi Tian, Shijie Luo, Chenyu Liang, Jialiang Huang^*, Rongshan Yu^*. Prioritizing prognostic-associated. subpopulations and individualized recurrence risk signatures from single-cell transcriptomes of colorectal cancer. Briefings in Bioinformatics, 2023 May 19;24(3):bbad078.
7.Mengsha Tong^#*; Shijie Luo; Lin Gu; Xinkang Wang; Zheyang Zhang; Chenyu Liang; Huaqiang Huang; Yuxiang Lin; Jialiang Huang^* ; SIMarker: Cellular similarity detection and its application to diagnosis and prognosis of liver cancer, Computers in Biology and Medicine, 2024 Mar:171:108113.
8.Mengsha Tong^#, Zan Liu^#, Jiaao Li^#, Xin Wei, Wenhao Shi, Chenyu Liang, Chunyu Yu, Rongting Huang, Yuxiang Lin, Xinkang Wang, Shun Wang, Yi Wang, Jialiang Huang, Yini Wang, Tingting Li^*, Jun Qin^*, Dongdong Zhan^*, Zhi-Liang Ji^*. PhosMap: An ensemble bioinformatic platform to empower interactive analysis of quantitative phosphoproteomics. Computers in Biology and Medicine, 2024 May:174:108391.
9. Jiaao Li^#, Jinyi Tian^#, Yachen Liu, Zan Liu, Mengsha Tong^*. Personalized analysis of human cancer multi-omics for precision oncology. Computational and Structural Biotechnology Journal, 2024 May 10:23:2049-2056. (邀稿综述)
10.Jiajing Xie^#, Ying Chen^#, Shijie Luo^#, Wenxian Yang, Yuxiang Lin, Liansheng Wang, Xin Ding^* Mengsha Tong^*, Rongshan Yu^*. BPformer: Tracing Unknown Tumor Origins with a Biological Pathway-based Transformer Model. Cell reports Methods, 2024 Jun 17;4(6):100797.
11. Yachen Liu , Yalan Lin, Yuxiang Lin, Yujuan,Wu, Zheyang Zhang, Nuoqi Lin, Xianlong Wang, Mengsha Tong^*, Rongshan Yu^*. Application of individualized differential expression analysis in human cancer proteome. Briefings in Bioinformatics, 2022 Apr 2;bbac096.
12.Mengsha Tong^#; Chunyu Yu^#; Jinwen Shi^#; Wenwen Huang^#; Sai Ge^#; Mingwei Liu; Lei;Song; Dongdong Zhan; Xia Xia;Wanlin Liu; Jinwen Feng; Wenhao Shi;Jiafu Ji; Jing Gao; Tieliu Shi; Weimin Zhu;Chen Ding; Yi Wang; Fuchu He^*; Lin Shen^*; Tingting Li^*; Jun Qin^*; Phosphoproteomics Enables Molecular Subtyping and Nomination of Kinase Candidates for Individual Patients of Diffuse-Type Gastric Cancer, iScience, 2019, 22: 44–57.
13.Mengsha Tong^#; Chunyu Yu ^#; Dongdong Zhan; Ming Zhang; Bei Zhen; Weimin Zhu; Yi Wang; Congying Wu; Fuchu He^*; Jun Qin^*; Tingting Li^*; Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: reanalysis of CPTAC ovarian cancer, EBioMedicine, 2018, 40 (2352-3964): 305-317.
14.Mengsha Tong^#; Weicheng Zheng^#; Hongdong Li; Xiangyu Li; Lu Ao; Yifeng Shen; Qirui Liang; Jing Li; Guini Hong; Haidan Yan; Hao Cai; Mengyao Li; Qingzhou Guan; Zheng Guo^*; Multi-omics landscapes of colorectal cancer subtypes discriminated by an individualized prognostic signature for 5-fluorouracil-based chemotherapy, Oncogenesis, 2016, 5(2157-9024).
15.Yifeng Shen^#; Mengsha Tong^#; Qirui Liang; Huaqin Sun; Weicheng Zheng; Lu Ao; Zheng Guo^*; Feifei She^*; Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells, The Pharmacogenomics Journal 2017, 18 (1470-269X): 23-28.
16.Siyuan You^#, Shuqin Li^#, Lingsu Zeng, Jinsheng Song, Zifeng Li, Weiyun Li, Hengxiao Ni, Xu Xiao, Wenbo Deng, Hongye Li, Wenbo Lin, Chenyu Liang, Yanfei Zheng, Shih-Chin Cheng, Nengming Xiao, Mengsha Tong, Rongshan Yu, Jialiang Huang, Hongling Huang, Hongzhi Xu, Jiahuai Han, Jianlin Ren and Kairui Mao.Treg-mregDC Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity. Cancer Cell. 2024 Aug 12;42(8):1415-1433.e12.
17. GaiGai Guo, Zhouyong Gao, Mengsha Tong, Dongdong Zhan,Guangshun Wang, Yi Wang, Jun Qin^*. NQO1 is a determinant for cellular sensitivity to anti-tumor agent Napabucasin. American Journal of Cancer Research 2020;10(5):1442-1454

荣誉、奖励及参加学术团体的情况:

福建省引进高层次人才(国内B类)；厦门市高层次人才(C类)；
人体蛋白质组导航国际大科学计划全球峰会暨第十二届中国蛋白质组学大会“明日之星”奖
福建省第七届高校青年教师教学竞赛二等奖；
厦门大学第十八届青年教师教学比赛一等奖；
厦门大学2025年优秀共产党员荣誉称号
厦门大学2024–2025年度“三八红旗手”
厦门大学2024年度中国联通数字化教研应用奖教金；
厦门大学生命科学学院2024年度优秀教学奖一等奖

中国生物信息学学会系统生物学专委会委员
福建省生物信息学学会理事；