2014年，中国农业大学生物科学专业，学士学位；
2019年，清华大学大学生物学专业，博士学位；
2019-2023年，美国可再生能源国家实验室（NREL），博士后；
2023年，厦门大学生命科学学院，副教授
B.S. China Agriculture University, College of Biological Sciences, 2010-2014;
Ph.D. 2019, Tsinghua University, School of Life Sciences, 2014-2019;
Postdoctoral Fellow, National Renewable Energy Laboratory, 2019-2023;
Associate Professor, School of Life Sciences, Xiamen University, starting from 2023.

通过合成生物学手段对微生物的代谢通路进行工程化改造，可以合成多种化合物，而深入理解微生物代谢机制则为理性设计改造提供了依据。我们实验室的研究聚焦于“如何”和“为何”两个核心问题，主要包含三个方向：1）通过代谢工程和实验室适应性进化，利用设计-构建-测试-学习（DBTL）循环，提高非模式微生物合成大宗化学品的效率；2）运用多组学方法解析非模式微生物的代谢机制，以实现最优合成通路；3）研究实验室适应性进化中转座酶介导的基因组重排，并基于此开发新型基因组编辑工具。
By leveraging synthetic biology to engineer microbial metabolic pathways, various compounds can be synthesized, and a deeper understanding of microbial metabolism enables more rational design for engineering modifications. Our lab focuses on the “how” and “why” of these processes, with three main research directions:
1) Enhancing the efficiency of bulk chemical synthesis in non-model microorganisms through metabolic engineering and laboratory adaptive evolution, using a Design-Build-Test-Learn (DBTL) cycle;
2) Utilizing multi-omics approaches to understand the metabolic mechanisms in non-model microorganisms to achieve optimal synthetic pathways;
3) Investigating transposase-mediated genome rearrangement during adaptive laboratory evolution, and developing novel genome editing tools based on these insights.

代表性论文(^# co-first author, ^* Corresponding author):

1. Yu-Hang Zhang, Chen-Ming Xue, Bai-Tao Chen, Pengfei Ouyang ^*, Chen Ling ^*. Comparing three emerging industrial cell factories: Pseudomonas putida KT2440, Halomonas bluephagenesis TD01, and Zymomonas mobilis ZM4. Current Opinion in Biotechnology, 2025. 92, 103255.
2. Chen Ling ^#, Ryan W. Clarke ^#, Gloria Rosetto ^#, Shu Xu, Robin M. Cywar, Dong Hyun Kim, Levi J. Hamernik, Stefan J. Haugen, William E. Michener, Sean P. Woodworth, Torrey M. Lind, Kelsey J. Ramirez, Meltem Urgun-Demirtas, Davinia Salvachúa, Christopher W. Johnson, Nicholas A. Rorrer, Gregg T. Beckham. Tunable and degradable dynamic thermosets from compatibilized polyhydroxyalkanoate blends. ACS Sustainable Chemistry & Engineering, 2025. 13 (9): 3817–3829.
3. Robin M. Cywar ^#, Chen Ling ^#, Ryan W. Clarke ^#, Donghyun Kim, Colin Kneucker, Davinia Salvachúa, Shu Xu, Meltem Urgun Demirtas, Bennett Addison, Nicholas Rorrer, Christopher W. Johnson, Robert Allen, Eugene Y.-X. Chen, Gregg T. Beckham ^*. Elastomeric vitrimers from designer polyhydroxyalkanoates with recyclability and biodegradability. Science Advances, 2023. 9(47), eadi1735.
4. Chen Ling, George L. Peabody, Davinia Salvachúa, Young-Mo Kim, Colin M. Kneucker, Christopher H. Calvey, Michela A. Monninger, Nathalie Munoz Munoz, Brenton C. Poirier, Kelsey J. Ramirez, Peter C. St. John, Sean P. Woodworth, Jon K. Magnuson, Kristin E. Burnum-Johnson, Adam M. Guss ^*, Christopher W. Johnson ^* & Gregg T. Beckham ^*. Muconic acid production from glucose and xylose in Pseudomonas putida via evolution and metabolic engineering. Nature Communications, 2022. 13(1): 1-14.
5. Chen Ling ^#, Guan-Qing Qiao ^#, Bo-Wen Shuai ^#, Kun-Nan Song, Wen-Xi Yao, Xiao-Ran Jiang ^*, Guo-Qiang Chen ^*. Engineering self-flocculating Halomonas campaniensis for wastewaterless open and continuous fermentation. Biotechnology and Bioengineering, 2019, 116(4): 805-815.
6. Chen Ling, Guan-Qing Qiao, Bo-Wen Shuai, Karel Olavarria, Jin Yin, Rui-Juan Xiang, Kun-Nan Song, Yun-Hao Shen, Yingying Guo ^*, Guo-Qiang Chen ^*. Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA). Metabolic Engineering, 2018, 49: 275-286.
7. Ying Wang, Chen Ling, Yong Chen, Xiao-Ran Jiang, Guo-Qiang Chen ^*. Microbial engineering for easy downstream processing. Biotechnology Advances, 2019. 37(6): 107365.
8. Qin Qin, Chen Ling, Yiqing Zhao, Tian Yang, Jin Yin, Yingying Guo ^*, Guo-Qiang Chen ^*. CRISPR/Cas9 editing genome of extremophile Halomonas spp. Metabolic Engineering, 2018, 47: 219-229.
9. Yilin Ren, Chen Ling, Ivan Hajnal, Qiong Wu, Guo-Qiang Chen ^*. Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production. Applied Microbiology and Biotechnology, 2018, 102 (10): 4499-4510.
10. Haitao Yue, Chen Ling, Tao Yang, Xiangbin Chen, Yuling Chen, Haiteng Deng, Qiong Wu, Jinchun Chen & Guo-Qiang Chen ^*. A seawater-based open and continuous process for polyhydroxyalkanoates production by recombinant Halomonas campaniensis LS21 grown in mixed substrates. Biotechnology for Biofuels, 2014, 7(1): 108.
11. Kevin J. McNaught, Eugene Kuatsjah, Michael Zahn, Andrew R. Pickford, Érica T. Prates, Chen Ling, Josephine N. Gruber, Kelley V. Hestmark, Caralyn J. Szostkiewicz, Brenton C. Poirier, Mowei Zhou, Dušan Veličković, Carrie D. Nicora, Young-Mo Kim, Gayle J. Bentley, Kristin E. Burnum-Johnson, Daniel A. Jacobson, John E. McGeehan, Christopher W. Johnson, Gregg T. Beckham ^*. Initiation of fatty acid biosynthesis in Pseudomonas putida KT2440. Metabolic Engineering, 2023, 76: 193-203.
12. Sekgetho Charles Mokwatlo, Bruno Colling Klein, Pahola Thathiana Benavides, Colin M. Kneucker, Chen Ling, Kelley V. Hestmark, Allison Z. Werner, Ryan Davis, Christopher W. Johnson, Gregg T. Beckham ^*, Davinia Salvachúa ^*. Bioprocess development and scale-up for cis, cis-muconic acid production from glucose and xylose by Pseudomonas putida. Green Chemistry, 2024, 26(19): 10152-10167.

荣誉、奖励及参加学术团体的情况:

Key Contributor Award, National Bioenergy Center, NREL （2023）
北京市优秀毕业生（2019）