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1月8日学术报告信息

发布时间:2019-01-07来源:生命科学学院点击数:150

报告题目Systematic analysis on cis-regulatory code of polyadenylation

  :陈炜,Ph. D. 

    南方科技大学生物系讲席教授

报告时间201918日(周二)15:00 PM

报告地点:生命科学学院E307学术报告厅

邀 请 人:肖昌春教授

联 系 人:洪雅贞

联系电话0592-2880315

报告摘要:Alternative polyadenylation (APA) can generate transcripts with distinct coding sequence (CDS) and/or 3’ untranslated regions (UTR), thereby influencing protein isoforms, mRNA stability and localization. Here, Prof. Chen will talk about two ongoing projects:
 First, he will discuss about the development of a high-throughput screening method to characterize the cis-elements regulating APA. Using this approach, they discovered dozens of novel cis-elements that can modulate PAS usage. Second, he will describe a deep learning architecture that can generate a predicative model to quantify the usage of multiple PAS in an APA-regulated gene. Through a combination of model adjustment and case study, they show how their model can potentially shed light on molecular mechanisms underlying APA regulation.