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陈兰芬教授博导

发布时间:2016-05-16来源:点击数:33428

陈兰芬副教授 

陈兰芬  CHEN Lanfen, Ph.D. 

闽江学者特聘教授,博士生导师

炎症与疾病Inflammation and Diseases

课题组组长

  : +86-592-2880305

E-mail:chenlanfen@xmu.edu.cn

 

1997年毕业于厦门大学生物学系生物化学专业,获理学学士学位;

2000年毕业于厦门大学生物学系生化和分子生物学专业,获硕士学位;

2006年毕业于美国纽约爱因斯坦医学院病理学专业,获博士学位;

2007年至2012年在美国哈佛医学院,布莱根妇女医院博士后

2012年6月-至今,厦门大学生命科学学院课题组长;

2014年获国家自然基金优秀青年基金资助;

2015年,入选福建省“闽江学者”特聘教授。

 

1997, B.Sc., Xiamen University;

2000, M.Sc, Xiamen University;

2006, Ph.D., Albert Einstein College of Medicine, New York.

2007-2012, Postdoctoral Fellow at Brigham and Women’s Hospital, Harvard Medical School, Boston;

2012-presentPrincipal Investigator for Inflammation and Diseases’ s group , School of Life Sciences, Xiamen University.

2013/08-presentProfessor, School of Life Sciences, Xiamen University.

 

研究领域(Research Area

Hippo 信号通路的Mst1激酶是T细胞活化,增殖和成熟的重要调节分子。本课题组主要运用转基因及条件性基因敲除与敲入小鼠模型,免疫疾病模型,流式细胞分析,和细胞培养等实验手段,研究Hippo信号通路在免疫系统调节和免疫相关疾病发生发展中的调控作用。以通讯作者在Cancer Cell、Nature Immunol、Cell Reports、Nature Commun、J Immunol等重要专业杂志发表多篇论文。

The Hippo pathway kinase Mst1, a homolog of the Drosphila tumor suppressor hippo, is a key determinant of peripheral T cell activation, proliferation and maturation. The combined deletion of Mst1 and Mst2 from the hematopoietic compartment results in the absence of all peripheral lymphocytes and a profound immunodeficiency syndrome. Our research group proposes to characterize the regulation and physiologic functions of the Hippo pathway in the immune system. 



 

代表性论文(Selected Publications, * Corresponding author 

1. Wang P, Geng J, Gao J, Zhao H, Li J, Shi Y, Yang B, Xiao C, Linghu Y, Sun X, Chen X, Hong L, Qin F, Li X, Yu JS, You H, Yuan Z, Zhou D, Johnson RL, Chen L*. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nature Commun. 2019;10(1):755. doi: 10.1038/s41467-019-08680-6.

2. Geng J, Yu S, Zhao H, Su X, Li X, Wang P, Xiong X, Hong L, Xie C, Gao J, Shi Y, Peng J, Johnson RL, Xiao N, Lu L, Han J, Zhou D*and Chen L*. TAZ regulates reciprocal differentiation of Th17 and Treg cells. Nature Immunol. 2017;18(7):800-812. (Cover Story; highlighted by Nature Reviews Rheumatology. 2017)

3. Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, Hong L, Xie C, Li X, Zhao H, Liu Q, Jiang M, Chen Q, Zhang J, Li Y, Song S, Wang HR, Zhou R, Johnson RL, Chien KY, Lin SC, Han J, Avruch J, Chen L*, Zhou D*. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature Immunol. 2015;16(11):1142-52. (Cover Story; highlighted by Nature Rev Immunol. 2015;15(11):667. doi: 10.1038/nri3931.)

4. Zhang S, Chen Q, Liu Q, Li Y, Sun X, Hong L, Ji S, Liu C, Geng J, Zhang W, Lu Z, Yin Z-Y, Zeng Y, Lin K-H, Wu Q, Li Q, Nakayama K, Nakayama KI, Deng X,. Johnson RL, Zhu L, Gao D, Chen L*, Zhou D*. Hippo signaling suppresses cell ploidy and tumorigenesis through Skp2. Cancer Cell. 2017;31(5):669-684.e7. (highlighted by Cancer Discovery.2017 May 26. doi: 10.1158/2159-8290.CD-RW2017-101).)

5. Hong L, Li X, Zhou D, Geng J, Chen L*. Role of Hippo signaling in regulating immunity. Cell Mol Immunol. 2018;15(12):1003-1009.

6.Hong L, Cai Y, Jiang M, Zhou D, Chen L*. The Hippo signaling pathway in liver regeneration and tumorigenesis. Acta Biochim Biophys Sin (Shanghai). 2015;47(1):46-52.

7. Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L*, Zhou D*. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nature Commun. 2015;6:6239. doi: 10.1038/ncomms7239.

8. Wu H, Xiao Y, Zhang S,Ji S, Wei L, Fan F,Geng J, Tian J, Sun X, Qin F, Jin C, Lin J, Yin Z-Y, Zhang T, Luo L, Li Y, Song S, Lin S-C, Deng X,Camargo F, Avruch J, Chen L*, Zhou D *. The Ets transcription factor GABP is a component of the Hippo pathway essential for growth and antioxidant defense. Cell Reports. 2013, 3(5):1663-77.

9. Qin F, Tian J, Zhou D, Chen L*. Mst1 and Mst2 kinases: regulations and diseases. Cell Biosci. 2013,3(1): 31.

10. Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, Yang Z, Wu SQ, Chen L, Han J*. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res. 2013, 23(8): 994-1006.

11. Chen L, Chen Z, Baker K, Halvorsen EM, Pires da Cunha A, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS*. The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction. Immunity. 2012, 37(5): 930-46.

12. Chen Z#, Chen L#, Baker K, Olszak T, Zeissig S, Mandelboim O, Beauchemin N, Lanier LL,. Blumberg RS*. CEACAM1 dampens anti-tumor immunity via bidirectional down-regulation of NKG2D ligand expression on tumor cells and NKG2D function on NK cells. J Exp Med. 2011, 208(13): 2633-40 (# co-first authorship)

13. Zhou D, Medoff BD, Chen L, Li L, Liu M, Landry A, Blumberg RS, Boussiotis V, Xavier R and Avruch J*. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci USA. 2008, 105(51): 20321-6 .

14. Chen L* and Brosnan CF. Regulation of immune response by P2X7 receptor. Critical review in immunology. 2006, 26(6): 499-51.

15. Chen L* and Brosnan CF. Exacerbation of experimental autoimmune encephalomyelitis in P2X7R-/- mice: evidence for loss of apoptotic activity. Journal of Immunology. 2006, 176(5): 3115-26. 

16. Chen L*, Cencioni MT, Angelini DF, Borsellino G, Battistini L and Brosnan CF. Transcriptional profiling of γδ T Cells identifies a role for vitamin D in the immunoregulation of the V9V2 response to phosphate-containing ligands. Journal of Immunology. 2005, 174(10): 6144-52.