欢迎访问厦门大学生命科学学院官方网站

王洪睿教授博导

发布时间:2015-05-19来源:点击数:17259

王洪睿教授博士生导师王洪睿 WANG Hong-Rui, Ph.D.

教授,博士生导师

课题组组长

  话:+86-592-2181167

E-mailwanghr@xmu.edu.cn

 

1992年,清华大学获学士学位;

1994年,清华大学获硕士学位;

1996年,中国科学院生物物理研究所获博士学位;

1996-1999年,美国加州理工大学博士后;

1999-2002年,加拿大多伦多西乃山医院研究所博士后;

2002-2008年,加拿大多伦多西乃山医院研究所高级研究助理;

2008年至今,厦门大学985平台特聘教授。

 

1992, B.Sc., Biochemistry, Tsinghua University;

1994, M.Sc., Biochemistry, Tsinghua University;

1996, Ph.D., Molecular Biology, Institute of Biophysics, Chinese Academy of Science;

1996-1999, Postdoctoral Scholar, Division of Biology, California Institute of Technology, Pasadena, USA;

1999-2002, Postdoctoral Fellow, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada;

2002-2008, Senior Research Associate, Samuel Lunenfeld Research Institute, Mount Sinai, Hospital, Toronto, Canada;

2008-Present, Professor of School of Life Sciences, Xiamen University. 


研究领域(Research Area

蛋白翻译后修饰与肿瘤发生发展:蛋白质的泛素化和类泛素化修饰对于调节各种细胞和机体生物学活性都起着十分重要的作用,其调控的紊乱会导致包括神经退行性疾病和癌症在内的多种重大疾病的发生。我们致力于研究蛋白质泛素化和类泛素化修饰在调控细胞生长、死亡、自噬以及肿瘤发生发展中的作用和分子机理。同时,在分子机理研究的基础上,以在肿瘤发生发展中起重要作用的泛素连接酶为靶点,进行抗肿瘤新型靶向药物的研发,以期获得癌症治疗的新的先导化合物。


Protein post-translational modifications such as ubiquitination and ubiquitin-like modification are key regulatory mechanisms that control various biological processes. Dysregulation of protein modification results in development of many human diseases like neurodegenerative disease and cancer. Our research interest has been focused on mechanism studies of ubiquitination and ubiquitin-like modification in regulation of cell proliferation, cell death, autophagy, and tumorigenesis. We are also working on identifying small-molecule modulators of E3 ubiquitin ligases that are critical for cancer development, which is emerging as a promising drug discovery strategy.



代表性论文 (Selected Publications)    

1.      Maoyuan Tian#, Taoling Zeng#, Mingdong Liu, Shang Han, Huayue Lin, Qi Lin, Li Li, Tingting Jiang, Gao Li, Hong Lin, Ting Zhang, Qiaofeng Kang, Xianming Deng*, Hong-Rui Wang*. A cell-based high-throughput screening method for modulators of E3 ligases using ubiquitin-reference-technique (URT) technique. J Biol Chem, 2019, 294(8): 2880-2891.

2.      Mingdong Liu#, Taoling Zeng#, Xin Zhang#, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao*, Hong-Rui Wang*.ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nature Communications, 2018, 9:4139.


3.     Zeng T#, Wang Q#, Fu J#, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H,Wang M, Lu B, Deng X, Zhou D, Yin Z*, Wang HR*.Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis. Cell Reports, 2014,7(3):871-82.

4.   Wang M#, Guo L#, Wu Q#, Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, RenL, Zhang S, Pei Y, Yin Z, Ding F, Wang HR*.ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance. Nature Communications, 2014, 5:4901.

5.   Xie P#, Zhang M#, He S#, Lu K, Chen Y, Xing G, Lu Y, Liu P, Li Y, Wang S, Chai N, Wu J, Deng H, Wang HR, Cao Y, Zhao F, Cui Y, Wang J, He F*, Zhang L*. The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis. Nat Commun. 2014 May 13;5:3733.

6.   Lin H#, Lin Q#, Liu M#, Lin Y, Wang X, Chen H, Xia Z, Lu B, Ding F, Wu Q, Wang HR*. PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis. Oncogene. 2014 Mar 27;33(13): 1629-39.

7.   Ding F, Yin Z, Wang HR*. Ubiquitination in Rho signaling. Curr Top Med Chem, 2011, 11(23): 2879-87

8.   Tian M#, Bai C#, Lin Q, Lin H, Liu M, Ding F, Wang HR*.Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity. FEBS lett, 2011, 585(14): 2199-04.

9.   Wang L#, Liu YT, Hao R, Chen L, Chang Z, Wang HR, Wang ZX, Wu JW*. Molecular mechanism of the negative regulation of Smad1/5 by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem, 2011, 286(18): 15883-94.

10.   Wiesner S*, Ogunjim AA, Wang HR, Rotin D, Sicheri F, Wrana JL*, Forman-Kay JD*. Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell, 2007, 130(4):651-662

11.   Wang HR#, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL*. Degradation of RhoA by Smurf1 ubiquitin ligase. Methods Enzymol, 2006, 406:437-47.

12.   Ozdamar B#, Bose R#, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL*. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science, 2005, 307(5715):1603-9.

13.Zhang Y, Wang HR, Wrana JL. Smurf1: a link between cell polarity and ubiquitination. Cell Cycle, 2004, 3(4):391-2.

14.Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science, 2003, 302(5651):1775-9.

15.Bonni S, Wang HR, Causing CG, Kavsak P, Stroschein SL, Luo K, Wrana JL.TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat Cell Biol, 2001, 3(6):587-95.