李博安博士  教授
    1996年在上海肿瘤研究所获博士学位
    1998至2006年先后在德国Max-Plank Institute for Biochemistry和美国University of  California , Irvine 学习、工作，先后任博士后和助理研究员,从事细胞信号转导、肿瘤与发育生物学以及抗HIV药物研究工作。
    2006年1月起回国任厦门大学生命科学学院985平台特聘教授，福建省闽江学者特聘教授, 博士生导师。
    美国细胞生物学学会(ASCB)会员
    美国科学发展协会(AAAS)会员

Boan Li, Ph.D. Professor of Molecular and Cellular Biology. He obtained his Ph.D degree from Shanghai Cancer Institute in 1986. Then he performed research work in the field of signal transduction, tumor and development biology, and anti-HIV drug research in Germany and the America from 1998 to 2006. He joined the faculty of Xiamen University College of Life Sciences from January, 2006. 

研究领域：
    Wnt信号通路在正常组织发育和肿瘤形成中起重要作用。我们克隆了小鼠pygopus2基因，该基因通过LgslBCL9与β-catenin结合，对Wnt信号强度起控制作用。我们已经构建了pygopus2的knockout小鼠模型，发现乳腺发育障碍是主要表型，同时Wnt信号强度明显减弱。我们还发现pygopus 在多种肿瘤组织内有高表达，因而将利用转基因小鼠模型研究其在肿瘤发生中的作用。与此同时，我们还发现pygopus2在某些Wnt信号阴性组织内有高表达，表明存在Wnt非依赖途径。我们将利用酵母双杂交和TAP(tandem affinity purification)技术分离pygopus的结合蛋白，以彻底阐明其作用机理。

Research interest:
    Wnt signaling is crucial for normal development and tumorigenesis. Pygopus is a newly found PHD finger protein which is recruited to β-catenin via an adaptor protein, Lgs/BCL9, and existing evidence suggests that Pygopus is required for the maximum activation ofβ-catenin/Lef1 dependent promoter/ genes in cell culture. We have cloned the mouse Pygopus2 gene and generated the knockout mouse model. Phenotype study indicated that the main defect in Pygopus2 mutant mouse is abnormality of mammary gland development. Meanwhile, the Wnt signaling is apparently decreased in mammary gland cells. Pygopus2 was also found upregulated in some tumor tissues. Therefore, the transgenic study will be conducted to look into the function of Pygopus2 in tomoerigenesis.  We also found the high levels of expression of Pygopus2 in some Wnt signaling negative tissues which indicates the existence of Wnt-independent pathway for Pygopus. Yeast two hybrid and TAP will be utilized to isolate the Pygopus binding proteins so that we elucidate the mechanisms of Pygopus in Wnt- dependent and independent pathways. 

获奖情况
    获1998年度军队科技进步一等奖，2000年军队重大科技成果奖。
    获4项基因专利： GENEBANK ACCESSION  NUMBER：AY090537；AY090538；AF487891；AY486147. 

 在研基金
    厦门大学“985” 平台启动经费 1项 (300万元) ;
    国家自然科学基金1项;
    国家863项目1项;
    国家973项目1项;

本实验室常年招收博士后,欢迎近年毕业的博士加盟!

联系方式:
  E-mail:  bali@xmu.edu.cn
  Tel:0592-2181987

1. Li, B*., Rhéaume C , Veltmaat J , Li A, Bilanchone V, Denmon A, Teng A,  Munguia JE, Hu M, Waterman ML, Lee EY,and Dai, X.(2006). Mouse pygopus 2 is required for epithelial morphogenesis, controls the amplitude of canonical Wnt signaling, and regulates embryonic mammary epithelial cell proliferation . Proc Natl Acad Sci, U S A. (in revision).
2. Ye Y, Li B*. 1'S-1'-Acetoxychavicol acetate (ACA) isolated from Alpinia galanga inhibits human immunodeficiency virus type 1 (HIV-1) by blocking Rev transport. Journal of general Virology. 2006;  87: 2047-2053
3. Nair M, Teng A, Bilanchone V, Agrawal A, Li B, Dai X. Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol. 2006; 24;173(2):253-64.
4.  Li, B*.,Zhao H， Bilanchone V., Fallahi, M., Paula E. Mahowald, AP., Fuchs, E and Dai, X。 Involement of Wnt signaling components hpygo1 and hpygo2 in human breast cancers. 2005 DOD Breast cancer Symposium.USA.
5. Mackay DR, Hu M, Li B, Rheaume C, Dai X. The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Jan 16;48,543-552. 
6. Li, B*., Nair, M., Mackay, DR., Bilanchone, V., Hu, M., Fallahi, M., Song, H., Dai, Q., Cohen, PE., Dai, X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005;132, 1463-1473.
7. Yan, HX., Wang, HY., Zhang, R., Chen, L., Li, B., Liu, SQ., Cao, HF., Qiu, XH., Shan, YF., Yan, ZH., Wu, HP., Tan, YX., Wu, MC. Negative regulation of hepatocellular carcinoma cell growth by signal regulatory protein alpha1.Hepatology. 2004; 40(3):618-28.
8. Li, B*., Mackay, DR., Ma, J., Dai, X. Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics. 2004; 84(2):398-405.
9. Li, B*., Dai, Q., Li, L., Nair, M., Mackey, D., Dai, X. Ovol2, a Mammalian Homolog of Drosophila ovo: Gene Structure, Chromosomal Mapping, and Aberrant Expression in Blind-Sterile Mice. Genomics. 2002; 80(3):319
10. Li, B*., Mackey, DR, Dai, Q., Li, TW., Nair M., Fallahi, M., Schonbaum, CP., Fantes, J., Mahowald, AP., Waterman, ML., Fuchs, E., Dai, X. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci, U S A. 2002; 30;99(9):6064-9.
11. Zhou XP, Wang HY, Yang GS, Chen ZJ, Li BA. , Wu MC： Cloning and expression of MXR7 gene in human HCC tissue.World J Gastroenterol. 2000;6(1):57-60.