电子信箱：cdyu@xmu.edu.cn

学历：

学士     1993年   中山大学生物学系

硕士     1996年   厦门大学生物学系

博士     2002年   美国德州大学休斯顿健康科学中心

科研经历：

1993-1996年   硕士研究生  厦门大学生物学系

1996-1997年   研究助理      福建省医学科学研究所

1997-1998年   研究助理      美国德州A&M大学

1998-2002年   博士研究生  美国德州大学休斯顿健康科学中心

2002-2006年   博士后         美国贝勒医学院

2006-至今        教授            厦门大学生命科学学院

主要研究领域：

1．研究核受体及其共激活子在肝脏代谢及肝脏疾病中的作用。

2．研究核受体及其共激活子在炎症反应及自身免疫疾病中的作   

      用。

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Chundong Yu, Ph.D.

Professor

Email: cdyu@xmu.edu.cn

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ACADEMIC BACKGROUND:
B.S.    1993  Zhongshan University
M.S.   1996  Xiamen University
Ph.D.  2002  University of Texas Health Science Center at Houston
RESEARCH AND PROFESSIONAL EXPERIENCE
1993-1996  M.S. Student, Xiamen University
1996-1997  Research Assistant, Fujian Institute of  Medical Sciences
1997-1998  Research Assistant, Texas  A&M University, U. S. A.
1998-2002  Ph.D. Student, University of Texas Health Science Center
2002-2006  Postdoctoral Fellow, Baylor College of Medicine, U.S.A.
2006-present Professor, School of Life Sciences, Xiamen University
Research interest:
1. Study the role of nuclear receptors/coactivators in liver metabolism and liver diseases.
2. Study the role of nuclear receptor/coactivators in inflammation and auto-immune diseases.

代表性论文（Representative Publication）

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    1. Yu, C., York, B., Wang, S., Feng Q., Xu, J., and O’Malley B. (2007) An Essential Function of the SRC-3 Coactivator in Suppression of Cytokine mRNA Translation and Inflammatory Response. Mol. Cell 25(5):765-778.
    2. Mussi, P., Yu, C., O’Malley, B., and Xu, J. (2006) Stimulation of Steroid Receptor Coactivator 3 (SRC-3) Gene Overexpression by A Positive Regulatory Loop of E2F1 and SRC-3. Mol. Endo. 20(12):3105-3119.
    3. Huang, X., Yu, C., Jin, C., Yang, C., Xie R., Cao D., Wang F., and McKeehan, W. (2006) Forced expression of liver fibroblast growth factor 21 delays initiation of chemically-induced hepatocarcinogenesis. Mol. Carcinog. 45(12):934-942.
    4. Huang, X., Yu, C., Jin C., Kobayashi, M., Bowles, C., Wang, F., and McKeehan, W.  (2006) Ectopic Activity of FGFR1 in Hepatocytes Accelerates Hepatocarcinogenesis by Driving Proliferation and VEGF-induced Angiogenesis. Cancer Res. 66: 1481-1490.
    5. Ma, W., Xia, X., Stafford, L.J., Yu, C., Wang, F., LeSage, G., and Liu, M. (2006) Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis. Oncogene 25(30):4207-4216.
    6. Yu, C., Wang, F., Huang, X., Jin, C., and McKeehan, W. (2005). Independent Repression of Bile Acid Synthesis and Activation of c-Jun N-terminal Kinase (JNK) by Activated Hepatocyte Fibroblast Growth Factor Receptor 4 (FGFR4) and Bile Acids.  J. Biol. Chem. 280: 17707-17714.
    7. Jin, C., Wang, F., Wu, X., Yu, C., Luo, Y., and McKeehan, W. (2004) Directionally-Specific Paracrine Communication Mediated by Epithelial FGF9 to Stromal FGFR3 in Two-compartment Premalignant Prostate Tumors.  Cancer Res. 64: 4555-4562.
    8. Yu, C., Wang, F., Jin, C., Huang, X., Miller, D., Basilico, C., and McKeehan, W. (2003). Role of Fibroblast Growth Factor Type 1 and 2 in Carbon Tetrachloride-induced Hepatic Injury and Fibrogenesis. Am. J. Pathol. 163(4): 1653-1662.
    9. Yu, C., Wang, F., Jin, C., Chan, W., Wu, X., and McKeehan, W. (2002). Increased Carbon Tetrachloride-induced Liver Injury and Fibrosis in FGFR4-deficient Mice. Am. J. Pathol. 161(6): 2003-2010
    10. Wang F., McKeehan, K., Yu, C., Kan, M., and McKeehan, W. (2002). Fibroblast Growth Factor Receptor 1 Phosphotyrosine 766: Molecular Target for Prevention of Progression of Prostate Tumors to Malignancy.  Cancer Res. 62: 1898-1903
    11. Wu, X., Kan, M., Wang, F., Jin, C., Yu, C., and McKeehan, W. (2001) A Rare Premalignant Prostate Tumor Epithelial Cell Syndecan-1 Forms an FGF-binding Complex with Progression-promoting Ectopic FGF receptor 1. Cancer Res. 61: 5295-5302.
    12. Jones, R., Wang, F., Luo, Y., Yu, C., Jin, C., Suzuki, T., Kan, M., and McKeehan, W. (2001) The Nonsense-Mediated Decay Pathway and Mutually Exclusive Expression of Alternatively Spliced FGFR2IIIb and IIIc mRNAs. J. Biol. Chem. 276: 4158-4167.
    13. Yu, C., Wang, F., Kan, M., Jin, C., Jones, R., Weinstein, M., Deng, C., and     McKeehan, W. (2000). Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4. J. Biol. Chem. 275: 15482-15489.